A5100340644- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Neonatal Respiratory Health Research
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Inflammasome and immune disorders
- Ubiquitin and proteasome pathways
- Gestational Diabetes Research and Management
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Immune Response and Inflammation
- Neuroscience and Neuropharmacology Research
- Autophagy in Disease and Therapy
Capital Medical University
2015-2025
Huazhong University of Science and Technology
2016-2025
Shandong University
2019-2025
Qilu Hospital of Shandong University
2024-2025
Shanghai University of Traditional Chinese Medicine
2024-2025
Shuguang Hospital
2025
Nanjing Medical University
2021-2025
Zhengzhou University
2021-2025
Shanxi Medical University
2008-2025
Southwest Jiaotong University
2025
Intracerebral hemorrhage (ICH) causes high mortality and morbidity, but our knowledge of post-ICH neuronal death related mechanisms is limited. In this study, we first demonstrated that ferroptosis, a newly identified form cell death, occurs in the collagenase-induced ICH model mice. We found administration ferrostatin-1, specific inhibitor prevented reduced iron deposition induced by hemoglobin organotypic hippocampal slice cultures (OHSCs). Mice treated with ferrostatin-1 after exhibited...
It is well-documented that the methylation of histone H3 lysine 4 (H3K4) and H3K9 are mutually exclusive, an epigenetic phenomenon conserved from yeast to humans. How this opposed modification accomplished coordinated in mammalian cells poorly understood. Here we report trimethyl demethylase JMJD2B integral component H3K4-specific methyltransferase, mixed-lineage leukemia (MLL) 2 complex. We show JMJD2B/MLL2 complex copurified with estrogen receptor α (ERα) required for ERα-regulated...
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of primates that centrally involved in cognition. We assessed more than 600,000 single-nucleus transcriptomes from adult human, chimpanzee, macaque, and marmoset dlPFC. Although most cell subtypes defined transcriptomically are conserved, we detected several exist only a subset species as well substantial species-specific molecular differences across homologous neuronal, glial, non-neural subtypes. latter...
The liquid-liquid phase separation (LLPS) of biomolecules in cell underpins the formation membraneless organelles, which are condensates protein, nucleic acid, or both, and play critical roles cellular function. Dysregulation LLPS is implicated a number diseases. Although has been investigated intensively recent years, knowledge prevalence distribution proteins (PSPs) still lag behind. Development computational methods to predict PSPs therefore great importance for comprehensive...
Electrolyte plays a vital role in determining battery performances, while the effect of solvent molecular interaction on electrode performances is not fully understood yet. Herein, we present an unrevealed dipole–dipole to show mechanism stabilizing electrolyte for high performances. As paradigm, new nonflammable triethyl phosphate (TEP)-based designed stabilize bulk alloying anode (e.g., Sb), where interfacial model constructed according solvation structure induced by between TEP and...
Ferroptosis is an iron-dependent form of non-apoptotic cell death implicated in liver, brain, kidney, and heart pathology. How ferroptosis regulated remains poorly understood. Here, we show that PPARα suppresses by promoting the expression glutathione peroxidase 4 (Gpx4) inhibiting plasma iron carrier TRF. directly induces Gpx4 binding to a PPRE element within intron 3. knockout mice develop more severe accumulation liver when fed high-iron diet than wild-type mice. Ferrous (Fe2+ ) triggers...
Abstract Neuroinflammation has emerged as a major concern in ischemic stroke therapy because it exacebates neurological dysfunction and suppresses recovery after ischemia/reperfusion. Fingolimod hydrochloride (FTY720) is an FDA‐approved anti‐inflammatory drug which exhibits potential neuroprotective effects brain parenchyma. However, delivering sufficient amount of FTY720 through the blood–brain barrier into lesions without inducing severe cardiovascular side remains challenging. Here,...
BackgroundMacrophages are innate immune cells whose phagocytosis function is critical to the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene 1 (Irg1) its metabolic product itaconate inhibit bacterial infection, intracellular viral replication, inflammation in macrophages. Here we explore whether regulates phagocytosis.MethodsPhagocytosis macrophages was investigated by time-lapse video recording, flow cytometry, immunofluorescence staining...
Abstract JARID1B is a member of the JmjC/ARID family demethylases that specifically demethylates tri- and di-methylated forms histone H3 lysine 4 (H3K4) are associated with active genes. expression dysregulated in several cancers which it has been implicated, but how might affect tumor progression unclear. In this study, we report physical component LSD1/NuRD complex functions transcriptional repression. LSD1 acted sequential coordinated manner to demethylate H3K4. A genome-wide analysis...
Abstract Background The mechanisms involved in the induction and regulation of inflammation resulting dopaminergic (DA) neurotoxicity Parkinson's disease (PD) are complex incompletely understood. Microglia-mediated has recently been implicated as a critical mechanism responsible for progressive neurodegeneration. Methods Mesencephalic neuron-glia cultures reconstituted were used to investigate molecular sinomenine (SN)-mediated anti-inflammatory neuroprotective effects both...
Although intracerebral hemorrhage (ICH) is a devastating disease worldwide, the pathologic changes in ultrastructure during acute and chronic phases of ICH are poorly described. In this study, transmission electron microscopy was used to examine ICH-induced pathology. induced mice by an intrastriatal injection collagenase. Pathologic were observed (3 days), subacute (6 (28 days) phases. Compared with sham animals, we various types cell death injured striatum phase ICH, including necrosis,...
FBP1, fructose-1,6-bisphosphatase-1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to 6-phosphate and inorganic phosphate. The mechanism that it functions antagonize glycolysis was epigenetically inactivated through NF-kappaB pathway in gastric cancer has been reported. However, its role liver carcinogenesis still remains unknown. Here, we investigated expression DNA methylation FBP1 primary HCC colon tumor. lowly expressed 80% (8/10) human...
Tamoxifen resistance is accountable for relapse in many ER-positive breast cancer patients. Most of these recurrent patients receive chemotherapy, but their chemosensitivity unknown. Here, we report that tamoxifen-resistant cells express significantly more BARD1 and BRCA1, leading to DNA-damaging chemotherapy including cisplatin adriamycin, not paclitaxel. Silencing or BRCA1 expression inhibition phosphorylation by Dinaciclib restores the sensitivity cells. Furthermore, show activated...