A5101920443- Ferroptosis and cancer prognosis
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Immune cells in cancer
- Neuroscience and Neuropharmacology Research
- Geomechanics and Mining Engineering
- Neuroendocrine regulation and behavior
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Simulation and Modeling Applications
- Histone Deacetylase Inhibitors Research
- Hormonal and reproductive studies
- Vibration Control and Rheological Fluids
- Exercise and Physiological Responses
- Parasitic infections in humans and animals
- Migraine and Headache Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Hereditary Neurological Disorders
- Proteoglycans and glycosaminoglycans research
- Advanced Graph Neural Networks
Capital Medical University
2015-2025
Zunyi Medical University
2024
Johns Hopkins Medicine
2024
Johns Hopkins University
2024
Nanjing University of Science and Technology
2022
Institute of Computing Technology
2018
Chinese Academy of Sciences
2018
University of Chinese Academy of Sciences
2018
Hunan Agricultural University
2011
BackgroundMacrophages are innate immune cells whose phagocytosis function is critical to the prognosis of stroke and peritonitis. cis-aconitic decarboxylase immune-responsive gene 1 (Irg1) its metabolic product itaconate inhibit bacterial infection, intracellular viral replication, inflammation in macrophages. Here we explore whether regulates phagocytosis.MethodsPhagocytosis macrophages was investigated by time-lapse video recording, flow cytometry, immunofluorescence staining...
Diabetic hyperglycemia aggravates the prognosis of intracerebral hemorrhagic stroke (ICH) in clinic. In addition to hematoma expansion and increased inflammation, how diabetic affects outcomes ICH is still unclear. We found that streptozotocin-induced not only neutrophil infiltration, but also changed gene expression profile neutrophils, including lactoferrin (Ltf) encoding Ltf. Peroxisome proliferator-activated receptor γ (PPARγ) transcribed Ltf lack neutrophilic transcription secretion...
Abstract Oligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature oligodendrocytes and enwrap growing or demyelinated axons during development post central nervous diseases. Failure of remyelination owing cell death undifferentiation OPCs contributes severe neurologic deficits motor dysfunction. However, how prevent the is still poorly understood, especially in hemorrhagic In current study, we injected autologous blood into mouse lateral ventricular study...
Abstract Background The nucleotide oligomerization domain (NOD)-like receptor family pyrin containing 3 (NLRP3) in dorsal root ganglion (DRG) contributes to pain hypersensitivity multiple neuropathic models, but the function of NLRP3 diabetic (DNP) and regulation mechanism are still largely unknown. Epigenetic plays a vital role controlling gene expression. Ten-eleven translocation methylcytosine dioxygenase 2 (TET2) is DNA demethylase that transcriptional activation. TET2 also involved high...
Spontaneous intracerebral hemorrhage (ICH) is a devastating disease with high morbidity and mortality worldwide. We have previously shown that ferroptosis contributes to neuronal loss in ICH mice. The overload of iron dysfunction glutathione peroxidase 4 (GPx4) promote post-ICH. However, how epigenetic regulatory mechanisms affect the ferroptotic neurons remains unclear. In current study, hemin was used induce N2A SK-N-SH cells mimic ICH. results showed hemin-induced accompanied by an...
Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis -aconitate to produce itaconate mitochondria. Itaconate serves as immunomodulator macrophages represses inflammation infectious diseases. Recently, a study showed that derivative inhibits neuroinflammation reduces chronic pain mice. However, function molecular mechanisms endogenous have not been fullyelucidated. In this study, content ipsilateral...
Glycans play important roles in a variety of biological processes. Their activities are closely related to the fine details their structures. Unlike simple linear chains proteins, branching is unique feature glycan structures, making identification extremely challenging. Multistage mass spectrometry (MSn) has become primary method for structural identification. The major difficulty MSn selection fragment ions as precursors next stage scanning. Widely used strategies either manual by...
Abstract Sequence variability in three mitochondrial DNA (mtDNA) regions, namely cytochrome c oxidase subunit 3 ( cox 3), NADH dehydrogenase subunits 1 and 4 nad 4) Spirometra erinaceieuropaei spargana from different geographical regions China was examined. A portion of each the (p 1) genes were amplified separately individual S. by polymerase chain reaction (PCR). Representative amplicons subjected to sequencing order estimate sequence variability. The sequences p 3, 541, 607 847 bp length,...
Stroke is classified as ischemic or hemorrhagic, and there are few effective treatments for either type. Immunologic mechanisms play a critical role in secondary brain injury following stroke, which manifests cytokine release, blood-brain barrier disruption, neuronal cell death, ultimately behavioral impairment. Suppressing the inflammatory response has been shown to mitigate this cascade of events experimental stroke models. However, clinical trials anti-inflammatory agents, long-term...
Traumatic brain injury (TBI) is a central nervous system disease caused by external trauma, which has complex pathological and physiological mechanisms. The aim of this study was to explore the correlation between immune cell infiltration ferroptosis post-TBI.This utilized GEO database download TBI data performed differentially expressed genes (DEGs) ferroptosis-related (FRDEGs) analysis. DEGs were further analyzed for enrichment using DAVID 6.8. Immunoinfiltration analysis ssGSEA package...
Background Mice play a crucial role in studying the mechanisms of general anesthesia. However, identifying reliable EEG markers for different depths anesthesia induced by multifarious agents remains significant challenge. Spindle activity, typically observed during NREM sleep, reflects synchronized thalamocortical activity and is characterized frequency range 7–15 Hz duration 0.5–3 s. Similar patterns, referred to as “anesthetic spindles,” are also variability anesthetic spindles across not...
The research on vibration characteristics and control of multi-body system is a focus in the field mechanical dynamics engineering. For controlled multibody system, transfer equation element total are derived this paper, controllability observability matrix method for linear analyzed. An example simulation shows that effective, engineering application has important theoretical practical significance to solve series major problems control.
To improve the dynamical test accuracy of an inertial measurement unit (IMU), magnetorheological elastomer (MRE) isolators were applied to suppress its vibration. In this paper, dynamics model a laser gyro strapdown IMU was developed based on Riccati transfer matrix method for multibody systems. Combining with different control algorithms, acceleration shell taken as object and vibration characteristics system calculated analysed. By comparing root mean square values components, it predicts...