A5102970327- Meat and Animal Product Quality
- Underwater Vehicles and Communication Systems
- CRISPR and Genetic Engineering
- Microbial Fuel Cells and Bioremediation
- Biocrusts and Microbial Ecology
- Glioma Diagnosis and Treatment
- Aquatic Ecosystems and Phytoplankton Dynamics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Energy Harvesting in Wireless Networks
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Cancer-related gene regulation
- Wireless Power Transfer Systems
- Membrane-based Ion Separation Techniques
- Anaerobic Digestion and Biogas Production
- Pain Mechanisms and Treatments
- Biochemical and Molecular Research
- Electrochemical sensors and biosensors
- Congenital gastrointestinal and neural anomalies
- Pharmaceutical and Antibiotic Environmental Impacts
- Ferroptosis and cancer prognosis
- Electromagnetic wave absorption materials
- Advanced Chemical Sensor Technologies
- Heavy metals in environment
Shanghai Ocean University
2022-2025
Binzhou University
2022-2025
Binzhou Medical University
2022-2025
Xiamen University
2025
Capital Medical University
2021-2025
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Tongji University
2016-2024
Wenzhou Medical University
2024
Technical University of Munich
2024
Although nanopores can be used for single-molecule sequencing of nucleic acids using low-cost portable devices, the characterization proteins and their modifications has yet to established. Here, we show that hydrophilic or glycosylated peptides translocate too quickly across FraC recognized. However, high ionic strengths (i.e., 3 M LiCl) low pH 3) together with a nanopore phenylalanine at its constriction allows recognition peptides, distinguish between mono- diglycosylated peptides. Using...
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide (vitamin B3) to generate 1-methylnicotinamide (MNA). NNMT overexpression has been linked a variety of diseases, most prominently human cancers, indicating its potential as therapeutic target. The development small-molecule inhibitors gained interest in recent years, with the potent sharing structural features based on elements substrate and S-adenosyl-l-methionine (SAM) cofactor. We here report new bisubstrate that include...
Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide (MNA) using S-adenosyl-l-methionine (SAM) as the methyl donor. The complexity of role NNMT in healthy and disease states is slowly being elucidated provides an indication that may be interesting therapeutic target for a variety diseases including cancer, diabetes, obesity. Most inhibitors described date are structurally related one or both its substrates. In search diverse inhibitors, mRNA display...
A novel, simple, and general method for preparing a highly dispersed supported metal catalyst was developed by modification of silica surface with ethylene glycol (EG) before the impregnation cobalt precursors. The modified support significantly improved dispersion oxide formed more Co3+ species on Co3O4 particles, resulting in very high catalytic activity CO oxidation. obtained catalysts were characterized XRD, TEM, XPS.
To investigate the effect of steaming time (0, 5, 10, 15, 20, and 25 min) on protein degradation non-volatile flavor substances swimming crab (Portunus trituberculatus), moisture content, total nitrogen (TN), non-protein (NPN), free amino acids (FAAs), nucleotides, electronic tongue analysis, sensory evaluation were determined. The results showed that contents NPN FAAs highest after crabs steamed for 10 min. Meanwhile, AMP (adenosine monophosphate) content reached maximum value (332.83...
Abstract Background Glioblastoma (GBM) characterized by immune escape is the most malignant primary brain tumors, which has strong immunosuppressive effect. Programmed death ligand-1 (PD-L1) a recognized member on surface of tumor cells, and plays crucial role in evasion tumors. Actually, little known about regulation PD-L1 expression GBM. Insulin-like growth factor binding protein 3 (IGFBP3) upregulated GBM related to poor patient prognosis. However, it remains unclear whether IGFBP3...
As a new and ubiquitous trace organic pollutant, endocrine-disrupting compounds (EDCs) can cause effects on organisms even at low levels. However, little information is available the resource assessment of EDC risks in water environment. The study area was selected based paucity pollution status inland lakes. Wuhan has numerous diverse types lakes which receive micropollutants from different pathways. In this study, spatial distribution, occurrence, quantity ecological EDCs 12 were...
Abstract Copy number variations (CNVs) play a vital role in regulating genes expression and tumorigenesis. We explored the copy alterations early-stage lung adenocarcinoma using high-throughput sequencing nucleic acid flight mass spectrometry technology, found that 8q22.1-22.2 is frequently amplified tissues. COX6C localizes on region its notably enhanced driven by amplification adenocarcinoma. Knockdown of significantly inhibits cell proliferation, induces S-G2/M cycle arrest, mitosis...
Hypertension has been identified as a significant risk factor for cardiovascular disease. Given the prevalence of adverse effects angiotensin-converting enzyme-inhibitory (ACEI) drugs, natural and effective alternatives to these medications need be identified. An investigative study was conducted assess ACEI capacity structural characteristics enzymatic hydrolysates with varying molecular weights derived from squid skin. The amino acid sequences digests were analyzed via Nano LC-MS/MS...
Abstract The mechanism of aroma formation in anchovies via various intermittent microwave drying counts were revealed by the associated variations flavor precursors compounds and volatile compounds. Variations structure compared with multidimensional infrared spectroscopy (MM‐IR), revealing that fatty acid exhibited notable transformations different counts. Anchovies presented similar compound compositions, whereas greater discrepancies observed concentration. There are 127 45 identified...