A5100427531- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Influenza Virus Research Studies
- Drug Transport and Resistance Mechanisms
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Acute Myeloid Leukemia Research
- Colorectal Cancer Treatments and Studies
- Hemoglobinopathies and Related Disorders
- Animal Disease Management and Epidemiology
- CAR-T cell therapy research
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Thermoregulation and physiological responses
- Cancer-related gene regulation
- Hepatitis B Virus Studies
- Infrared Thermography in Medicine
- COVID-19 and healthcare impacts
- Multiple Myeloma Research and Treatments
Huadong Hospital
2023-2024
Fudan University
2023-2024
Nanjing University of Chinese Medicine
2024
University of Missouri
2023-2024
Yunnan Yingmao Biotechnology (China)
2024
Central South University
2013-2024
Zhongnan Hospital of Wuhan University
2023-2024
Wuhan University
2022-2024
Missouri College
2023-2024
Dalian Medical University
2024
Abstract In Parkinson’s disease and other synucleinopathies, the elevation of α-synuclein phosphorylated at Serine129 (pS129) is a widely cited marker pathology. However, physiological role for pS129 has remained undefined. Here we use multiple approaches to show first time that functions as regulator neuronal activity. Neuronal activity triggers sustained increase in cultured neurons (200% within 4 h). accord, brain elevated environmentally enriched mice exhibiting enhanced long-term...
Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular condition, but approved medical therapies to prevent AAA progression and rupture are currently lacking. Sphingolipid metabolism disorders associated with the occurrence development of AAA. It has been discovered that ganglioside GM3, sialic acid-containing type glycosphingolipid, plays protective role in atherosclerosis, which an important risk factor for AAA; however, potential contribution GM3 not investigated. We...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads efficiently by spike-mediated, direct cell-to-cell transmission. However, the underlying mechanism is poorly understood. Herein, we demonstrate that tight junction protein occludin (OCLN) critical to this process. SARS-CoV-2 infection alters OCLN distribution and expression causes syncytium formation leads viral spread. knockdown fails alter binding but significantly lowers internalization, formation, overexpression also...
The barrier function of nasal mucosal epithelial cells plays an irreplaceable role in the spread and expansion viruses body. This study found that influenza A virus H1N1 could induce apoptosis progenitor cells, cause inflammatory response, trigger maturation recruitment submucosal dendritic (DCs), but mechanism remained unclear. Therefore, we used RNA sequencing high-resolution untargeted metabolomics to sequence perform combined bioinformatic analysis virus-infected from 6 different...
Inflammation plays an important role in the occurrence and development of neuropathic pain. Immune-responsive gene 1 (IRG1) decarboxylates cis -aconitate to produce itaconate mitochondria. Itaconate serves as immunomodulator macrophages represses inflammation infectious diseases. Recently, a study showed that derivative inhibits neuroinflammation reduces chronic pain mice. However, function molecular mechanisms endogenous have not been fullyelucidated. In this study, content ipsilateral...
Abstract Background Striae distensae (SD) is a challenging cosmetic condition. Ablative fractional laser (AFL) an effective method for treating SD. Recently, radiofrequency (FRF) has been shown to be promising treatment SD; however, few studies have the differences between FRF and AFL in of Aims This study aimed evaluate compare clinical efficacy safety bipolar with 2940‐nm erbium yttrium aluminum garnet (Er:YAG) Patients/Methods Twenty volunteers abdominal SD were enrolled this study. One...
Hemagglutination inhibition (HI) and virus neutralization antibody (nAb) do not always correlate with the protection of H7 avian influenza vaccines in mammals humans. The contribution different classes antibodies induced by H7N9 to is poorly characterized chickens. In this study, responses both inactivated viral-vectored chickens were dissected. Chickens immunized vaccine showed 50% seroconversion rate low HI nAb titers at week 3 post immunization. However, elicited 100% terms high levels...
In the fifth wave of H7N9 avian influenza epidemic, highly pathogenic (HPAI) A (H7N9) viruses have emerged and pose a great challenge to public health poultry industry. addition, there are apparent genetic antigenic variations between classical virus newly-emerged virus. Therefore, an antigenic-match vaccine is required for prevention control in China. this study, recombinant Newcastle disease (NDV)-vectored expressing HA derived from prevailing HPAI (GD15) was generated using reverse...
To characterize the clinical features of IgG4-related disease (IgG4-RD) and analyze peripheral T lymphocyte subsets cytokine levels.A total 52 patients with newly diagnosed IgG4-RD were enrolled in retrospective study. Baseline characteristics examinational findings systematically reviewed.IgG4-RD had a male predominance, an average age 57.4 ± 10.3 years (range 27-81). The mean number involved organs was 2.7 1-8). Submandibular gland (57.7%) lacrimal gland/orbit (40.4%) most commonly organs....
Before 2013, zoonotic influenza infections were dominated by H5N1 viruses in China. However, the emergence of H7N9 early 2013 changed this dominance greatly, and more than 1,600 laboratory-confirmed human cases have been reported since then. To understand underlying mechanism fifth epidemic wave that shows an unexpected sharp increase, we systematically investigated biological characteristics highly pathogenic (HP) low-pathogenic (LP) AIVs during period. We first analysed haemagglutination...
Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a disorder causing cognitive impairments.We use the auditory verbal learning test (AVLT), clock drawing (CDT), Wechsler intelligence scale for children (WISC) and Montreal assessment (MoCA) to evaluate memory spatial impairments of OSHAS in 6-12 years old patients with different severity.A total 137 snoring were enrolled following inclusion criteria this study. According indices (AHI), they divided into three groups. The AVLT, CDT, WISC...
Background: Reactivating fetal globin (HbF) is a promising treatment for β-hemoglobinopathies. Using gene editing to mimic these mutations should reactivate γ-globin in patients with transfusion-dependent β-thalassemia (TDT) and ameliorate the symptoms of patients. RM-001 novel cell therapy that uses non-viral, ex vivo CRISPR-Cas9 autologous hematopoietic stem progenitor cells (HSPCs) at promoter genes (HBG1/2) disrupt binding site BCL11. Aims: Here, we present available safety efficacy...
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To investigate the effect of nuclear protein 1 (Nupr1) on pathological progression osteoarthritis and its relationship with ferroptosis chondrocytes.