A5100559904- Soybean genetics and cultivation
- Catalytic Processes in Materials Science
- Analytical Chemistry and Chromatography
- MRI in cancer diagnosis
- Pelvic and Acetabular Injuries
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- Renal Diseases and Glomerulopathies
- Medical Research and Treatments
- Technology and Security Systems
- Advanced biosensing and bioanalysis techniques
- Advanced Battery Materials and Technologies
- Catalysis and Oxidation Reactions
- Systemic Lupus Erythematosus Research
- Radiomics and Machine Learning in Medical Imaging
- Plant Pathogens and Resistance
- Advanced oxidation water treatment
- Peptidase Inhibition and Analysis
- Hernia repair and management
- Advanced MRI Techniques and Applications
- Speech and Audio Processing
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Military Defense Systems Analysis
- Mine drainage and remediation techniques
Henan University of Technology
2023-2025
Carbon180
2025
China International Science and Technology Cooperation
2025
Lanzhou University
2022-2025
China Geological Survey
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Third Xiangya Hospital
2025
Central South University
2025
Jilin University
2024
Sun Yat-sen University
2020-2024
Aqueous Zn-ion batteries (AZIBs) attract intensive attention owing to their environmental friendliness, cost-effectiveness, innate safety, and high specific capacity. However, the practical applications of AZIBs are hindered by several adverse phenomena, including corrosion, Zn dendrites, hydrogen evolution. Herein, a anode decorated with 3D porous-structured Na3 V2 (PO4)3 (NVP@Zn) is obtained, where NVP reconstruct electrolyte/anode interface. The resulting NVP@Zn can provide large quantity...
Uncontrollable dendrite growth and corrosion induced by reactive water molecules sulfate ions (SO
Selective CDK2 inhibitors have the potential to provide effective therapeutics for CDK2-dependent cancers and combating drug resistance due high cyclin E1 (CCNE1) expression intrinsically or CCNE1 amplification induced by treatment of CDK4/6 inhibitors. Generative models that take advantage deep learning are being increasingly integrated into early discovery hit identification lead optimization. Here we report a highly potent selective macrocyclic inhibitor QR-6401 (23) accelerated...
Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for poor prognosis of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic interventions cerebral I/R are still very limited. Melatonin, an endogenous hormone, was found to be valid in preventing a variety organs. However, systematic review covering all neuroprotective effects melatonin has not been reported yet. Thus, we perform comprehensive overview influence on by collecting available...
Abstract A visible‐light‐promoted cascade difluoromethylation/cyclization reaction to access various difluoromethylated pyrrolo[1,2‐ a ]indolediones was developed using difluoromethyltriphenylphosphonium bromide salt as the difluoromethylating reagent. possible radical mechanism has been investigated and proven single electron transfer (SET) procedure.
The barrier function of nasal mucosal epithelial cells plays an irreplaceable role in the spread and expansion viruses body. This study found that influenza A virus H1N1 could induce apoptosis progenitor cells, cause inflammatory response, trigger maturation recruitment submucosal dendritic (DCs), but mechanism remained unclear. Therefore, we used RNA sequencing high-resolution untargeted metabolomics to sequence perform combined bioinformatic analysis virus-infected from 6 different...
Semi-supervised learning(SSL) can substantially improve the performance of deep neural networks by utilizing unlabeled data when labeled is scarce. The state-of-the-art(SOTA) semi-supervised algorithms implicitly assume that class distribution datasets and are balanced, which means different classes have same numbers training samples. However, they hardly perform well on minority imbalanced. Recent work has found several ways to decrease degeneration learning models in class-imbalanced...
An effective method for accessing diverse difluoroalkylated pyrrolo[1,2-a]indolediones via visible-light-induced PhI(OAc)2-promoted cascade difluoroalkylation/cyclization reaction under mild conditions has been established. This is noteworthy its use of DMSO-H2O as a green medium at room temperature and avoidance photocatalysts. The reactions are straightforward to execute convenient expand on, provide good excellent yields, have functional group tolerance.
Abstract Background For most women who have had a previous cesarean section, vaginal birth after section (VBAC) is reasonable and safe choice, but which will increase the risk of adverse outcomes such as uterine rupture. In order to reduce risk, we evaluated factors that may affect VBAC established model for predicting success rate trial labor (TOLAC). Methods All patients gave at Northwest Women’s Children’s Hospital from January 2016 December 2018, history voluntarily chose TOLAC were...
A novel chiral group functionalized metal-organic framework, Cyclodextrin-NH-MIL-53, was synthesized and modified on the inner wall of a capillary column via post-synthetic process. The prepared framework utilized as stationary phase used in an open-tubular electrochromatography method to enantioseparate several racemic amino acids. Excellent enantioseparation five pairs enantiomers obtained this separation system (Resolutions D/L-Alanine = 16.844, D/L-Cysteine 3.617, D/L-Histidine 9.513,...
Medical imaging provides many valuable clues involving anatomical structure and pathological characteristics. However, image degradation is a common issue in clinical practice, which can adversely impact the observation diagnosis by physicians algorithms. Although extensive enhancement models have been developed, these require well pre-training before deployment, while failing to take advantage of potential value inference data after deployment. In this paper, we raise an algorithm for...
Acute lung injury (ALI) is a severe complication of sepsis, and its underlying pathological mechanisms remain poorly understood. This study aims to investigate the role by which IRGM mediates autophagy through regulation AKT/mTOR signaling pathway in sepsis-induced ALI. Initially, ALI mouse model was established using cecal ligation puncture (CLP). Our results demonstrated that Irgm1 expression significantly upregulated model. Subsequently, knocked down vivo AAV vectors, changes symptoms...
Background Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons, marked complex pathological mechanisms and lack effective treatments. Despite substantial global research efforts, no comprehensive bibliometric analysis has systematically mapped the evolution ALS biomarkers, therapeutic targets, pharmacological advancements. Methods This study, based on 4,250 publications retrieved from Web Science Core Collection...
Abstract Background: Hepatocellular Carcinoma (HCC) is a very aggressive malignant cancer characterized by high incidence and mortality rates, which signs it continues to be challenge for today's therapeutics. Aberrant FGF19-FGFR4 signaling occurs in approximately 30% of HCC patients drives tumorigenesis progression. Therefore, selectively targeting inhibiting FGFR4 promisingly effective safe therapeutic approach. Methods Results: Here, we report novel, highly active, selective oral small...
Abstract Background: The development and clinical application of KRASG12C inhibitors have made significant progress in recent years some groundbreaking results been reported. However, overcoming resistance KRASG12C-OFF covalent blockade remains a key focus the fight against mutated cancers. Combination therapy may be one best treatment strategies to overcome resistance. Methods Results: HJ-037 is an orally available, potent, highly selective inhibitor, which showed significantly superior...
Abstract Background: KRAS is one of the most common mutated oncogenes in cancer, which primarily stimulates tumor growth by activating MAPK pathway. Tumors with non-KRASG12C mutations, such as KRASG12D, KRASG12V, and other codon mutation subtypes, currently lack compelling precision medicines. Therefore, development pan-KRAS inhibitor an unmet pressing clinical need. Methods Results: Here, we report a novel, orally bioavailable (ON) HJ-099, designed to treat various mutation-driven tumors....
Background: RAS mutations dominate tumorigenesis as they account for approximately 30% of human cancer cases, and are common in various solid tumor types such pancreatic ductal adenocarcinoma (PDAC), non-small cell lung (NSCLC), colorectal (CRC). Nowadays, the field mutated tumors treatment, only KRASG12C selective inhibitors have been approved, nonetheless, patients prone to acquire resistance those inhibitors. Yet there is still a lack innovative treatments cancers harboring other mutation...