A5100390780- Nerve injury and regeneration
- Nerve Injury and Rehabilitation
- Wound Healing and Treatments
- CAR-T cell therapy research
- Electrospun Nanofibers in Biomedical Applications
- Spine and Intervertebral Disc Pathology
- Neurogenetic and Muscular Disorders Research
- Advanced MRI Techniques and Applications
- Chronic Lymphocytic Leukemia Research
- Reproductive Biology and Fertility
- Systemic Lupus Erythematosus Research
- Selenium in Biological Systems
- Folate and B Vitamins Research
- T-cell and B-cell Immunology
- Trace Elements in Health
- Hydrogels: synthesis, properties, applications
- Advanced Electron Microscopy Techniques and Applications
- RNA modifications and cancer
- Medical Imaging and Analysis
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Menstrual Health and Disorders
- Biochemical Acid Research Studies
- Molecular Sensors and Ion Detection
- Spinal Cord Injury Research
Peking University
2008-2025
First Affiliated Hospital of Zhengzhou University
2021-2025
Peking University People's Hospital
2008-2025
Shanxi University
2025
ZheJiang Academy of Agricultural Sciences
2023-2024
Jiangxi Provincial Cancer Hospital
2024
Dalian Jiaotong University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2021-2024
State Key Laboratory of Medicinal Chemical Biology
2023
Qingdao University
2016-2023
Recently, this laboratory identified a proton-coupled folate transporter (PCFT), with optimal activity at low pH. PCFT is critical to intestinal absorption and transport into the central nervous system because there are loss-of-function mutations in gene autosomal recessive disorder, hereditary malabsorption. The current study addresses role might play another pathway, receptor (FR)-mediated endocytosis. FRα cDNA was transfected novel PCFT+ PCFT– HeLa sublines. shown bind trap folates...
Abstract Background Muscle wasting is a common complication of chronic kidney disease (CKD) that associated with higher mortality. Although the mechanisms myofibre loss in CKD has been widely studied, contribution muscle precursor cell (MPC) senescence remains poorly understood. Senescent MPCs no longer proliferate and can produce proinflammatory factors or cytokines. In this study, we tested hypothesis secretory phenotype (SASP) contributes to CKD‐induced atrophy weakness. Methods was...
Monodisperse cubic-phase KYF4 : Eu3+ nanocrystals (NCs) were synthesized via a modified thermal decomposition method. The optical properties of in NCs including multiple luminescence centers, site symmetry, dynamics, as well crystal-field levels investigated detail based on high-resolution photoluminescence (PL) spectroscopy at low temperature (10 K). Different from bulk counterparts, sites revealed by using the sensitive structural probe. highest symmetry new near-surface was deduced to be...
Abstract N6-methyladenosine (m 6 A), the most abundant internal modification in eukaryotic mRNA, is installed by a multi-component writer complex; however, exact roles of each component remain poorly understood. Here we show that potential E3 ubiquitin ligase Hakai colocalizes and interacts with other m A components, mutants exhibit typical pathway defects Drosophila , such as lowered levels aberrant Sxl alternative splicing, wing behavior defects. Hakai, Vir, Fl(2)d Flacc form stable...
The present study aimed to confirm whether the ratio of S-adenosylmethionine (SAM) S-adenosylhomocysteine (SAH) is a sensitive indicator, and it can be used as biomarker for clinical diagnosis atherosclerosis. Apolipoprotein E (ApoE)-/- mice were randomly divided into four groups fed with high methionine diet 15 weeks. Serum levels homocysteine (Hcy) measured using an automatic biochemistry analyzer. concentrations SAM SAH determined high‑performance liquid chromatography. methylation B1...
Objective Renal fibrosis is the common pathological foundation of many chronic kidney diseases (CKDs). The aim this study was to investigate whether Hydroxysafflor yellow A (HSYA) can preserve renal function by inhibiting progression and potential mechanisms. Methods induced unilateral ureteral obstruction (UUO) performed on 7-week-old C57BL/6 mice. HSYA (10, 50 100 mg/kg) were intragastrically administered. Sham group model administered with same volume vehicle. Serum samples collected 14...
Abstract Objective Spinal muscular atrophy (SMA) is a motor neuron disorder encompassing 5q and non-5q forms, causing muscle weakness due to spinal cord cell degeneration. Understanding its genetic basis crucial for counseling personalized treatment options. Methods This study retrospectively analyzed families of patients suspected SMA at our institution from February 2006 March 2024. Various molecular techniques, including multiplex ligation-dependent probe amplification analysis,...
Spin alignment based Rb-87 magnetometry with free spin precession has been proposed. A 795-nm linearly polarized laser beam, serving as the pump beam and probe propagates through a cylindrical enriched atomic vapor cell along Z axis, polarization orientation aligned Y axis. Simultaneously, static magnetic field B0⃗ is applied π/2 pulse radio-frequency (RF) BRF⃗ Given that direction aligns field, exhibits π polarization. This induces symmetric population distribution of ground-state atoms...
Wound healing is a complex but precise physiological process. Howener, existing treatments are often difficult to meet the needs of different wound healing. With background that exogenous electrical stimulation (ES) has been proven be effective in regulating cell behavior, we constructed electroactive dressing derived from carbon nanotubes (CNT) by electrospinning technology. The scaffold moderate hydrophilicity, which benefits collecting effusion, adhering site, and safely removing....
Pulmonary surfactant is required for lung function at birth and throughout life. Lung lipid homeostasis requires regulation among multi-tiered processes, coordinating the synthesis of proteins lipids, their assembly, trafficking, storage in type II cells lung. The mechanisms regulating these interrelated processes are largely unknown. We integrated mRNA microarray data with array independent knowledge using Gene Ontology (GO) similarity analysis, promoter motif searching, protein interaction...
Combining the advantages of photon sieves (PSs) and compound Fresnel zone plates (CZPs), we designed (CPSs) for hard-x-ray nanofocusing. A CPS consists an inner PS using first-order diffraction surrounded by outer plate third-order diffraction. robust digital prolate spheroidal window was used as apodization PS, making CPSs more flexible than CZPs. can provide not only slightly better resolution compared to CZPs, but also it significantly suppress sidelobes, leading a high signal-to-noise...
Adoptive immunotherapy using CD19-targeted Chimeric antigen receptor T cells (CAR-T) has revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Data is limited on propensity infections and lymphohematopoietic reconstitution after Day 30 (D30) following CAR-T cell therapy. In this study, we evaluated prevalence nature infectious complications in an expanded cohort DLBCL patients treated with CD19 therapy its association dynamics leukocyte subpopulation...
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease characterized by alveolar epithelial cell injury and fibroblast overactivation. At present, only two drugs are approved the FDA for treatment of IPF, including synthetic pyridinone drug, pirfenidone, tyrosine kinase inhibitor, nintedanib. Avitinib (AVB) novel oral potent third-generation inhibitor treating non-small cancer (NSCLC). However, role avitinib in has not yet been established. In present study,...
Abstract Background Patients with abnormally invasive placenta (AIP) are at high risk of massive postpartum hemorrhage. Resuscitative endovascular balloon occlusion the aorta (REBOA), as an adjunct therapeutic strategy for hemostasis, offers obstetrician alternative treating patients AIP. This study aimed to evaluate role REBOA in hemorrhage control Methods was a historical cohort prospectively collected data between January 2014 July 2021 single tertiary center. According delivery...
Severe trauma with massive active blood loss, including liver and spleen rupture, arterial bleeding pelvic fracture, will lead disability, malformation even death. Therefore, it is very important to develop new, fast efficient hemostatic materials. In this study, a novel Gelatin/Kaolin (GE/KA) composite sponge was developed. Meanwhile, further investigate the effect of kaolin content on properties, we prepared four types sponges: GE/5% KA, GE/10% GE/15% KA GE/20% KA. The results coagulation...
To investigate the changes of calcitonin gene-related peptide (CGRP) in rat's blood plasma, spinal anterior motorneuron, and dorsal root ganglion (DRG) after fractures combined with central or peripheral nerve injuries its influence on fracture healing, 72 healthy adult SD rats (male female) were divided into 4 groups (18 each group): group A, simple(left) tibial fracture; B, left sciatic injury; C, T9-11 cord transection D, right cerebral cortex injury. Group A was control group. The...