A5075537143- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- T-cell and Retrovirus Studies
- Cancer Treatment and Pharmacology
- SARS-CoV-2 and COVID-19 Research
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Complement system in diseases
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Economic and Financial Impacts of Cancer
- Neutropenia and Cancer Infections
- Gastric Cancer Management and Outcomes
- Animal Disease Management and Epidemiology
- Colorectal Cancer Screening and Detection
- Long-Term Effects of COVID-19
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Neuroendocrine Tumor Research Advances
- Vector-Borne Animal Diseases
The Ohio State University
2023-2025
The Ohio State University Wexner Medical Center
2023-2025
University of Massachusetts Chan Medical School
2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2023-2024
Albert Einstein College of Medicine
2020-2023
Montefiore Medical Center
2020-2023
Cleveland Clinic
2017-2020
Kettering Medical Center
2020
Hashemite University
2020
Yeshiva University
2020
Mortality in coronavirus disease of 2019 (COVID-19) is associated with increases prothrombotic parameters, particularly D-dimer levels. Anticoagulation has been proposed as therapy to decrease mortality, often adjusted for illness severity. We wanted investigate whether anticoagulation improves survival COVID-19 and if this improvement This a cohort study simulating an intention-to-treat clinical trial, by analyzing the effect on mortality chosen first 48 hours hospitalization. analyzed...
This cohort study assesses the prevalence of lupus anticoagulant (LA) positivity in patients with coronavirus disease 2019 (COVID-19) and examines association LA patient outcomes.
Abstract The causes of coagulopathy associated with coronavirus disease 2019 (COVID-19) are poorly understood. We aimed to investigate the relationship between von Willebrand factor (VWF) biomarkers, intravascular hemolysis, coagulation, and organ damage in COVID-19 patients study their association severity mortality. conducted a retrospective 181 hospitalized randomly selected balanced distribution survivors nonsurvivors. Patients who died had significantly lower ADAMTS13 (a disintegrin...
ABSTRACT The causes of coagulopathy associated with COVID-19 disease are poorly understood. We aimed to investigate the relationship between markers endothelial activation, intravascular hemolysis, coagulation, and organ damage in patients study their association severity mortality. conducted a retrospective 181 hospitalized randomly selected equal distribution survivors non-survivors. Patients who died had significantly lower ADAMTS13 activity, higher LDH, schistocytes von Willebrand Factor...
TPS795 Background: The recurrence rates and outcomes in resectable pancreatic ductal adenocarcinoma (R-PDA) is concerningly high. benefit of neoadjuvant chemotherapy over traditional upfront surgery followed by adjuvant therapy not clear. Electromagnetic fields generate bi-directional forces on highly polar intracellular components, causing abnormal microtubule polymerization during spindle formation irregular cleavage furrow formation. We will leverage these anti-proliferative effects...
Abstract BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality in US. 5-fluorouracil (5-FU)-based chemotherapies combination with targeted agents remain standard care patients metastatic or locally advanced disease. New treatment strategies are needed for CRC microsatellite stable Preclinical studies showed that riluzole, an oral medicine amyotrophic lateral sclerosis, inhibits glutamate release and synergizes 5-FU to reduce cell viability lines....
This study examines Generation Z students' smartphone buying intentions at Malaysian higher education institutions. The Theory of Planned Behavior (TPB) was chosen for its usefulness in studying intentions. evaluates purchase based on key factors such as attitudes (ATT), subjective norms (SN), perceived behavioral control (PBC), and enjoyment (PE). quantitative collected data via survey questionnaires. students are the targeted population. An analysis 384 completed surveys done. found that...
e14653 Background: ICI with gemcitabine and cisplatin (GC-ICI) has become a first-line (FL) standard of care in BTC following the success TOPAZ KEYNOTE-966 trials. A clear understanding factors impacting efficacy will help selecting optimal treatment strategies. This single institute retrospective study is aimed at achieving this. Methods: Patients receiving from 1/2017 6/2023 Ohio State University were evaluated. The patient's baseline characteristics (BL, first dose ICI) extracted details...
e14652 Background: IrAEs, commonly studied as tumor-agnostic effects of immune checkpoint inhibitors (ICI), require individualization based on baseline (BL) clinical characteristics and tumor type. This study evaluates TS-RF HM to predict irAE incidence, recovery, their impact overall survival (OS) in GI-M. Methods: A single-center retrospective review was conducted GI-M patients treated with ≥2 ICI doses between 1/2015–7/2021 (upper GI (UGI), lower (LGI), anal (Al)) 1/2015–6/2023...
4149 Background: Novel blood-based biomarkers are needed for early risk stratification and personalized therapies patients with PDA. An evidence-based 99-gene panel was developed focusing on genes whose protein products implicated in PDA drug response. We hypothesized that methylation levels these could serve as surrogates their corresponding activity, enabling the prediction of treatment-related outcomes patients. Using this panel, we a cell-free DNA (cfDNA)-based PEp-sig Methods: Targeted...
The spectrum of infectious complications in autologous hematopoietic cell transplant recipients (AHCT) with multiple myeloma has not been well described the recent era novel agent induction and improved supportive care.We conducted a retrospective cohort study 413 adult AHCT at our institution from 2007-2016 to describe cumulative incidence risk factors for various infections FN occurring within first 100 days after AHCT. Additionally, landmark analysis was done among 404 patients who...
Adoptive immunotherapy using CD19-targeted Chimeric antigen receptor T cells (CAR-T) has revolutionized the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Data is limited on propensity infections and lymphohematopoietic reconstitution after Day 30 (D30) following CAR-T cell therapy. In this study, we evaluated prevalence nature infectious complications in an expanded cohort DLBCL patients treated with CD19 therapy its association dynamics leukocyte subpopulation...
Adult T-cell leukemia/lymphoma (ATLL) remains challenging to treat and has dismal outcome. Allogeneic stem-cell transplantation (allo-SCT) promising results, but data remain scarce. In this single-center retrospective analysis of 100 patients with ATLL from north America (67 acute, 22 lymphomatous), 17 underwent allo-SCT 5 autologous SCT (ASCT), a median follow-up 65 months. Post-transplant 3-years relapse incidence (RI) non-relapse mortality (NRM) were 51% 37%, respectively, 3-year...
Introduction Communication between healthcare providers and patients is a key component associated with the quality of patient satisfaction. Often, simple communication skills may be insufficient to sustain successful provider-patient relationship. The aim this project was assess improve nurse satisfaction physicians via improvement in physician-patient physician-nurse level greater than 90%. Methods Initial surveys were given nurses on admission regular nursing floor current rates....
Background: Mortality in coronavirus disease of 2019 (COVID-19) is associated with increases prothrombotic parameters, particularly D-dimer levels. Many institutions have adopted anticoagulation guidelines, often adjusted for illness severity. We wanted to investigate whether improves survival COVID-19 and if this improvement severity.Methods: To simulate an intention treat clinical trial, we analyzed the effect on mortality therapy chosen first 48 hours hospitalization. 3,625 COVID-19+...
COVID-19 has caused a worldwide illness and New York became the epicenter of in United States from Mid-March to May 2020.To investigate coagulopathic presentation COVID its natural course during early stages surge York. To whether hematologic coagulation parameters can be used assess severity death.Retrospective case study positive inpatients between March 20, 2020-March 31, 2020.Montefiore Health System main hospital, Moses, large tertiary care center Bronx.Adult with tests hospitalized at...