A5100337145- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Gestational Diabetes Research and Management
- MicroRNA in disease regulation
- Global Maternal and Child Health
- Cancer-related molecular mechanisms research
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Solid State Laser Technologies
- Maternal and Perinatal Health Interventions
- Photorefractive and Nonlinear Optics
- Endometrial and Cervical Cancer Treatments
- Pregnancy-related medical research
- Gut microbiota and health
- Uterine Myomas and Treatments
- Medical Research and Treatments
- Neonatal and fetal brain pathology
- Global Health Care Issues
- Renal Diseases and Glomerulopathies
- Healthcare Systems and Reforms
- Endometriosis Research and Treatment
Shandong University
2001-2025
Academy of Medical Sciences
2024-2025
Xuzhou Medical College
2020-2025
State Key Laboratory of Reproductive Medicine
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Academia Sinica
2025
Shandong First Medical University
2022-2024
Qingdao University
2015-2024
Affiliated Hospital of Qingdao University
2015-2024
Medway Maritime Hospital
2024
Pretransplant antibodies, particularly anti-CD40, correlate with risk of recurrent focal segmental glomerulosclerosis after kidney transplant.
Beth Payne and colleagues use a risk prediction model, the Pre-eclampsia Integrated Estimate of RiSk (miniPIERS) to help inform clinical assessment triage women with hypertensive disorders pregnancy in low-resourced settings. Please see later article for Editors' Summary
Melatonin (Mel) has neuroprotective effects; however, its roles in hypoxic-ischemic brain damage (HIBD) and the underlying mechanisms remain unknown. We aimed to explore a HIBD rat model. found that exogenous Mel treatment ameliorated HIBD-induced pathological changes, inhibited neuronal ferroptosis, promoted hippocampal survival. Moreover, improved learning memory abilities of rats. Further, we glutathione peroxidase 4 (Gpx4) inhibition with RSL3, Akt LY29400, nuclear factor...
Abstract Background This study aims to provide a theoretical basis for the prevention of oral cancer by analyzing epidemiological trends cancer. Materials and Methods The data on from 1990 2019 were extracted Global Burden Disease database. incidence, mortality, disability‐adjusted life years (DALYs), age‐standardized rate as well attributable risk factors used analysis. Estimated annual percentage change (EAPC) was calculated describe changes in incidence (ASIR), mortality (ASMR), DALYs...
Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the cardiovascular metabolic systems. As nutrition important to support optimal development placenta for developing fetus, diets may play role in preventing pre-eclampsia. The purpose this scoping review map nutritional deficiencies imbalances associated with pre-eclampsia incidence discuss evidence consistency linkages current understandings etiology
Affecting 2-4% of pregnancies, pre-eclampsia is a leading cause maternal death and morbidity worldwide. Using routinely available data, we aimed to develop validate novel machine learning-based clinical setting-responsive time-of-disease model rule out in adverse outcomes women presenting with pre-eclampsia.
Preeclampsia (PE) is a common obstetrical disorder characterized by hypertension and proteinuria. The aberrant expression of miR-221-3p in placental tissues has been implicated the pathogenesis PE. This study examined role trophoblast growth, invasion migration, explored underlying mechanisms. Our results showed that was down-regulated from PE patients compared to heathy controls as measured quantitative real-time PCR assay. CCK-8 assay, Transwell assay wound healing overexpression promoted...
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). To understand how AD-MSCs regulated trophoblast function, we treated trophoblasts with AD-MSC-derived exosomes under hypoxic conditions. The markedly enhanced proliferation and autophagy. Furthermore, significant decrease EZH2 levels inactivation mTOR signaling...
In the current paper, three activity-based colorimetric and ratiometric fluorescent probes based on a naphthalimide fluorophore were well designed synthesized, which can be recognized hydrolyzed by aminopeptidase N (APN) at both enzymatic cellular level following emission wavelength change from blue to green light. As result, these molecules successfully identified as first for APN cell imaging.
Pregnancy hypertension is associated with 7.1% of maternal deaths in India. The objective this trial was to assess whether task-sharing care might reduce adverse pregnancy outcomes related delays triage, transport, and treatment. Indian Community-Level Interventions for Pre-eclampsia (CLIP) open-label cluster randomised controlled (NCT01911494) recruited pregnant women 12 clusters (initial four-cluster internal pilot) Belagavi Bagalkote, Karnataka. CLIP intervention (6 clusters) consisted...
Importance Early recognition of metabolic bone disease (MBD) in infants is necessary but difficult; an appropriate tool to screen at risk developing MBD needed. Objectives To develop a predictive model for neonates the prenatal and postnatal periods detect pivotal exposed factors each period. Design, Setting, Participants A diagnostic study was conducted from January 1, 2012, December 31, 2021, Shanghai, China. total 10 801 pregnant women (singleton pregnancy, followed up until 1 month after...
To reduce all-cause maternal and perinatal mortality major morbidity through Lady Health Worker (LHW)-facilitated community engagement early diagnosis, stabilization referral of women with preeclampsia, an important contributor to adverse outcomes given delays in detection initial management. In the Pakistan Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomized controlled trial (NCT01911494), LHWs engaged community, recruited pregnant from 20 union councils (clusters),...
BackgroundIncomplete vital registration systems mean that causes of death during pregnancy and childbirth are poorly understood in low-income middle-income countries. To inform global efforts to reduce maternal mortality, we compared physician review computerised analysis verbal autopsies (interpreting [InterVA] software), understand their agreement on cause circumstances mortality categories (COMCATs) the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised...
The placenta is particularly susceptible to inflammation and oxidative stress, leading placental vascular dysfunction insufficiency, which associated with fetal intrauterine growth restriction (IUGR). It unknown whether folic acid (FA) supplementation can alleviate high-fat diet-induced IUGR in rats by improving function. In this study, pregnant were randomized into one of four diet-based groups: (1) control diet (CON), (2) supplemented FA, (3) (HFD), (4) FA (HFD + FA). Dams sacrificed at...
Abstract STUDY QUESTION Do offspring born to mothers with poor ovarian response (POR) have alterations in their reproductive endocrine profile at 2 6 years of age compared those normal response? SUMMARY ANSWER Female young (<35 years) expected POR were more likely low serum anti-Müllerian hormone (AMH) levels childhood. WHAT IS KNOWN ALREADY affects 32-43% women infertility clinics. Genetic susceptibility and potentially adverse intrauterine environments pose threats the next...