A5007882853- Pregnancy and preeclampsia studies
- Global Maternal and Child Health
- Maternal and fetal healthcare
- Birth, Development, and Health
- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Mobile Health and mHealth Applications
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Healthcare Systems and Reforms
- Child Nutrition and Water Access
- Global Health and Surgery
- Maternal and Neonatal Healthcare
- Pregnancy and Medication Impact
- Maternal and Perinatal Health Interventions
- ICT in Developing Communities
- Vaccine Coverage and Hesitancy
- Global Health and Epidemiology
- Sepsis Diagnosis and Treatment
- Pregnancy-related medical research
- Ethics in Clinical Research
- Trauma and Emergency Care Studies
- Gestational Diabetes Research and Management
- Artificial Intelligence in Healthcare
- Cardiac, Anesthesia and Surgical Outcomes
University of British Columbia
2016-2025
British Columbia Children's Hospital
2017-2025
Women's Health Research Institute
2019-2025
Clinical Research Management
2024
B.C. Women's Hospital & Health Centre
2014-2023
Makerere University
2022
Uganda Cancer Institute
2022
University of British Columbia Hospital
2018-2022
King's College London
2017-2021
Creative Commons
2021
Beth Payne and colleagues use a risk prediction model, the Pre-eclampsia Integrated Estimate of RiSk (miniPIERS) to help inform clinical assessment triage women with hypertensive disorders pregnancy in low-resourced settings. Please see later article for Editors' Summary
Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and considered overestimates. We estimated population-based rates by standardised methods 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.CLIP-eligible pregnant women identified their homes or local primary health centres (2013-2017). Included here who had delivered trial end received a visit community worker trained to...
The development of mobile applications for the diagnosis and management pregnant women with pre-eclampsia is described. These are designed use by community-based health care providers (c-HCPs) in facilities during home visits to collect symptoms perform clinical measurements (including pulse oximeter readings). data collected used as inputs a predictive model providing risk score adverse outcomes. Based on this risk, provide recommendations treatment, referral, reassessment. c-HCPs can...
Pre-eclampsia is one of the leading causes maternal death and morbidity in low-resource countries due to delays case identification a shortage health workers trained manage disorder. Integrated Estimate RiSk (PIERS) on Move (PotM) low cost, easy-to-use, mobile (mHealth) platform that has been created aid making decisions around management hypertensive pregnant women. PotM combines two previously successful innovations into mHealth app: miniPIERS risk assessment model Phone Oximeter.The aim...
Early-onset preeclampsia is associated with severe maternal and perinatal complications. The fullPIERS model (Preeclampsia Integrated Estimate of Risk) showed both internal external validities for predicting adverse outcomes within 48 hours women admitted at any gestational age. This ability to recognize the highest risk complications earlier could aid in preventing these through improved management. Because majority (≈70%) development had late-onset preeclampsia, we assessed performance...
Affecting 2-4% of pregnancies, pre-eclampsia is a leading cause maternal death and morbidity worldwide. Using routinely available data, we aimed to develop validate novel machine learning-based clinical setting-responsive time-of-disease model rule out in adverse outcomes women presenting with pre-eclampsia.
ObjectivesTo evaluate the performance of Modified Early Obstetric Warning System (MEOWS) to predict maternal ICU admission in an obstetric population.DesignCase-control study.SettingTwo maternity units Vancouver, Canada, one with facilities, between January 1, 2000, and December 31, 2011.PatientsPregnant or recently delivered (≤6 weeks) women admitted hospital for >24 hours. Three control patients were randomly selected per case matched year admission.Measurements Main ResultsRetrospective,...
The fullPIERS model is a risk prediction developed to predict adverse maternal outcomes within 48 h for women admitted with pre-eclampsia. External validation of the required before implementation clinical use. We assessed temporal and external validity in high income settings using five cohorts collected between 2003 2016, from tertiary hospitals Canada, United States America, Finland Kingdom. were grouped into three datasets assessing primary external, validity, broader transportability...
The hypertensive disorders of pregnancy are leading causes maternal mortality and morbidity, especially in low- middle-income countries. Early identification women with preeclampsia other at high risk complications will aid reducing this health burden. fullPIERS model (Preeclampsia Integrated Estimate Risk) was developed for predicting adverse outcomes from using data tertiary centers high-income countries uses demographics, signs, symptoms, laboratory tests as predictors. We aimed to assess...
Pregnancy hypertension is associated with 7.1% of maternal deaths in India. The objective this trial was to assess whether task-sharing care might reduce adverse pregnancy outcomes related delays triage, transport, and treatment. Indian Community-Level Interventions for Pre-eclampsia (CLIP) open-label cluster randomised controlled (NCT01911494) recruited pregnant women 12 clusters (initial four-cluster internal pilot) Belagavi Bagalkote, Karnataka. CLIP intervention (6 clusters) consisted...
Cervical cancer is almost entirely preventable through vaccination and screening, yet remains one of the 'gravest threats to women's lives' according World Health Organization. Specific high-risk subtypes human papillomavirus (HR-HPV) are well-established as primary cause cervical cancer. Uganda has highest incidence rates in world (54.8 per 100,000) a result limited screening access infrastructure. The integration self-collected program using HPV testing within existing community-based...
Maternal deaths from preeclampsia primarily result in cases with eclampsia, uncontrolled hypertension, or progressing HELLP syndrome. Delivery is the only cure for preeclampsia. Management strategies involve determination of risk factors to predict which pregnancies are at high adverse maternal outcomes. Previous attempts develop assessment models that could identify potential predictive outcomes occurring any time after admission have been unsuccessful. The aim this prospective multicenter...
The fullPIERS (Pre‐eclampsia Integrated Estimate of RiSk) model is a promising tool for the prediction adverse outcomes in pre‐eclampsia, developed using worst values predictor variables measured within 48 hours admission. We reassessed performance obtained 6 and 24 admission, found that stratification capacity, calibration ability, classification accuracy remained high. accurate as rule‐in test maternal outcome, with likelihood ratio 14.8 (95% CI 9.1–24.1) or 17.5 11.7–26.3) based on 6‐...