Mark Brown

ORCID: 0000-0002-4759-9407
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About
Contact & Profiles
Research Areas
  • Pregnancy and preeclampsia studies
  • Birth, Development, and Health
  • Dialysis and Renal Disease Management
  • Maternal and fetal healthcare
  • Pregnancy and Medication Impact
  • Gestational Diabetes Research and Management
  • Blood Pressure and Hypertension Studies
  • Palliative Care and End-of-Life Issues
  • Electrolyte and hormonal disorders
  • Organ Donation and Transplantation
  • Cardiovascular Issues in Pregnancy
  • Hormonal Regulation and Hypertension
  • Health Systems, Economic Evaluations, Quality of Life
  • Sodium Intake and Health
  • Cardiovascular Health and Disease Prevention
  • Chronic Kidney Disease and Diabetes
  • Cardiac, Anesthesia and Surgical Outcomes
  • French Urban and Social Studies
  • Hemodynamic Monitoring and Therapy
  • Cultural Identity and Heritage
  • Renal function and acid-base balance
  • Pediatric Urology and Nephrology Studies
  • Reproductive System and Pregnancy
  • Theatre and Performance Studies
  • Ethics in medical practice

St George Hospital
2016-2025

UNSW Sydney
2015-2025

St. George Hospital
2008-2024

Sutherland Hospital
2016-2024

Cardinal Health (United States)
2023

Vanderbilt University Medical Center
2023

National Health Service
2022

University of Southampton
2022

Colorado State University
2017-2022

Daegu Cyber University
2022

Treatment of hypertension with diuretics, beta-blockers, or both leads to improved outcomes. It has been postulated that agents inhibit the renin–angiotensin system confer benefit beyond reduction blood pressure alone. We compared outcomes in older subjects who were treated angiotensin-converting–enzyme (ACE) inhibitors those diuretic agents.

10.1056/nejmoa021716 article EN New England Journal of Medicine 2003-02-13

This is the Executive Summary of updated guidelines developed by Society Obstetric Medicine Australia and New Zealand for management hypertensive diseases pregnancy. They address a number challenging areas including definition severe hypertension, use automated blood pressure monitors, non‐proteinuric pre‐eclampsia measuring proteinuria. Controversial issues are addressed such as treatment hypertension other significant manifestations pre‐eclampsia, role expectant in remote from term,...

10.1111/j.1479-828x.2009.01003.x article EN Australian and New Zealand Journal of Obstetrics and Gynaecology 2009-06-01

Survival, symptom burden, and quality of life (QOL) are uncertain for elderly patients with advanced CKD managed without dialysis. We examined these outcomes in renal supportive care dialysis (RSC-NFD) those planned or commencing

10.2215/cjn.03330414 article EN Clinical Journal of the American Society of Nephrology 2015-01-23
David C.H. Harris Simon Davies Fredric O. Finkelstein Vivekanand Jha Jo‐Ann Donner and 90 more Georgi Abraham Aminu K. Bello Fergus Caskey Guillermo García-García Paul Harden Brenda R. Hemmelgarn David W. Johnson Nathan W. Levin Valérie A. Luyckx Dominique Martin Mignon McCulloch Mohammed Rafique Moosa Philip J. O’Connell Ikechi G. Okpechi Roberto Pecoits–Filho Kamal D. Shah Laura Solá Charles R. Swanepoel Marcello Tonelli Ahmed Twahir Wim Van Biesen Cherian Varghese Chih‐Wei Yang Carlos Zúñiga‐Ramírez A K Abu Alfa Harith M. Aljubori Mona Alrukhaimi Sharon Andreoli Gloria Ashuntantang Ezequiel Bellorín-Font Bassam Bernieh Fuad M. Ibhais Peter G. Blake Mark Brown Edwina A. Brown Sakarn Bunnag Tak Mao Chan Yuqing Chen Rolando Claure‐Del Granado Stefaan Claus Alan Collins Cécile Couchoud Alfonso M. Cueto‐Manzano Brett Cullis Walter Douthat Gavin Dreyer Somchai Eiam‐Ong Felicia U. Eke John Feehally Mohammad Ghnaimat Bak Leong Goh Mohamed Hassan Fan Fan Hou Kitty J. Jager Kamyar Kalantar‐Zadeh Rümeyza Kazancıoğlu Adeera Levin Adrian Liew Marla McKnight Yewondwassesn Tadesse Mengistu Rachael L. Morton Elmi Muller Fliss EM Murtagh Saraladevi Naicker Masaomi Nangaku Abdou Niang Gregorio T. Obrador Shahrzad Ossareh Jeffrey Perl Muhibur Rahman Harun Ur Rashid Marie Richards Éric Rondeau Manisha Sahay Abdulkarim Saleh Daniel Schneditz Irma Tchokhonelidze Vladimı́r Tesař Michele Trask Kriang Tungsanga Tushar J. Vachharajani Rachael Walker Robert Walker Anthony J.O. Were Qiang Yao Karen Yeates Xueqing Yu Elena Zakharova Alexander Zemchenkov Ming‐Hui Zhao

The global nephrology community recognizes the need for a cohesive strategy to address growing problem of end-stage kidney disease (ESKD). In March 2018, International Society Nephrology hosted summit on integrated ESKD care, including 92 individuals from around globe with diverse expertise and professional backgrounds. attendees were 41 countries, 16 participants 11 low- lower-middle-income countries. purpose was develop strategic plan improve worldwide access by identifying prioritizing...

10.1016/j.kint.2018.12.005 article EN cc-by-nc-nd Kidney International 2019-03-20

Objective To determine the likelihood of progression from gestational hypertension (GH) to pre‐eclampsia (PE) in hypertensive pregnant women and whether this change can be identified advance by available clinical laboratory measures. Design A retrospective analysis a prospective study. Setting St George Hospital, Sydney, teaching hospital University New South Wales delivering 2500 per year. Population Eight hundred forty‐five with new second half pregnancy, managed uniform protocol (661...

10.1111/j.1471-0528.1998.tb09971.x article EN BJOG An International Journal of Obstetrics & Gynaecology 1998-11-01

Twenty-four hour ambulatory blood pressure thresholds have been defined for the diagnosis of mild hypertension but not its treatment or other used in moderate to severe hypertension. We aimed derive age and sex related equivalents clinic hypertension.We collated 24 data, recorded with validated devices, from 11 centres across six Australian states (n=8575). least product regression assess relation between these measurements measured by trained staff a smaller cohort doctors (n=1693).Mean...

10.1136/bmj.c1104 article EN cc-by-nc BMJ 2010-04-14

Objective To determine whether outcomes differed for women with pre-eclampsia according to the presence of proteinuria and non-proteinuric is similar gestational hypertension. Design From 1987 2005, at three hospitals in Sydney, Australia, referred obstetric medicine team were recruited. Outcomes groups compared: proteinuric pre-eclampsia, Results Women more likely have severe hypertension (39 versus 30%, P = 0.003), deliver preterm infants 0.007) had a higher perinatal mortality rate (25.2...

10.1097/hjh.0b013e3282f1a953 article EN Journal of Hypertension 2008-02-01

Although most national guidelines for the diagnosis and management of hypertension emphasize that initiation modification blood pressure (BP)-lowering treatment should be related to absolute cardiovascular disease (CVD) risk, there is only limited information on how incorporate ambulatory BP (ABP) monitoring into this framework. The objective initiative provide ABP equivalents cut-points targets included guidelines.A critical analysis best available evidence from clinical trials...

10.1097/hjh.0b013e32834de621 article EN Journal of Hypertension 2011-12-16

Objective To develop a core outcome set for pre‐eclampsia. Design Consensus development study. Setting International. Population Two hundred and eight‐one healthcare professionals, 41 researchers 110 patients, representing 56 countries, participated. Methods Modified Delphi method Nominal Group Technique. Results A long‐list of 116 potential outcomes was developed by combining the reported in 79 pre‐eclampsia trials with those derived from thematic analysis 30 in‐depth interviews women lived...

10.1111/1471-0528.16319 article EN cc-by BJOG An International Journal of Obstetrics & Gynaecology 2020-05-16
Tünde Montgomery-Csobán Kimberley Kavanagh Paul Murray Chris Robertson Sarah Barry and 95 more Ugochinyere Vivian Ukah Beth A. Payne K. H. Nicolaides Argyro Syngelaki Olivia Ionescu Ranjit Akolekar Jennifer A. Hutcheon Laura A. Magee Peter von Dadelszen Mark Brown Gregory K. Davis Claire E. Parker Barry N J Walters Nelson Sass J. Mark Ansermino Vivien Cao Geoffrey W. Cundiff Emma C.M. von Dadelszen M. Joanne Douglas Guy A. Dumont Dustin Dunsmuir Jennifer A. Hutcheon K.S. Joseph Sayrin Lalji Tang Lee Jing Li Kenneth Lim Sarka Lisonkova Paula Lott Jennifer M. Menzies Alexandra Millman Lynne Palmer Beth A. Payne Ziguang Qu James A. Russell Diane Sawchuck Dorothy Shaw Douglas K. Still Ugochinyere Vivian Ukah Brenda Wagner Keith R. Walley Dany Hugo The late Andrée Gruslin George Tawagi Graeme N. Smith Anne‐Marie Côté Jean‐Marie Moutquin Annie Ouellet Shoo K. Lee Tao Duan Jian Zhou The late Farizah Haniff Swati Mahajan Amanda Noovao Hanna Karjalainend Alja Kortelainen Hannele Laivuori J. Wessel Ganzevoort Henk Groen Phillipa M. Kyle M. Peter Moore Barbra Pullar Zulfiqar A Bhutta Rahat Qureshi Rozina Sikandar The late Shereen Z. Bhutta Garth Cloete David Hall The late Erika van Papendorp D.W. Steyn Christine Biryabarema Florence Mirembe Annettee Nakimuli John Allotey Shakila Thangaratinam K. H. Nicolaides Olivia Ionescu Argyro Syngelaki Michael de Swiet Laura A. Magee Peter von Dadelszen Ranjit Akolekar James J. Walker Stephen C. Robson Fiona Broughton-Pipkin Pamela Loughna Manu Vatish Christopher W.G. Redman Sarah Barry Kimberley Kavanagh Tunde Montgomery-Csobán Paul Murray Chris Robertson Eleni Tsigas Douglas Woelkers

Affecting 2-4% of pregnancies, pre-eclampsia is a leading cause maternal death and morbidity worldwide. Using routinely available data, we aimed to develop validate novel machine learning-based clinical setting-responsive time-of-disease model rule out in adverse outcomes women presenting with pre-eclampsia.

10.1016/s2589-7500(23)00267-4 article EN cc-by The Lancet Digital Health 2024-03-21

Acute renal failure (ARF) is a recognised complication following cardiac surgery, but the incidence varies widely in published literature and there are no Australian data available to help predict risks of ARF patients with pre-existing disease.To determine incidence, outcome risk factors for surgery.A retrospective case control analysis 903 consecutive who had surgery (795 CABG, 68 valve/septal 40 combined valve/CABG) 1992-93. was defined as doubling serum creatinine concentration (Cr) >...

10.1111/j.1445-5994.1995.tb01891.x article EN Australian and New Zealand Journal of Medicine 1995-08-01

Objective White coat hypertension (WCH) is a common phenomenon with long term prognosis intermediate between those true and normotension. The natural history of this throughout pregnancy remains unknown. We assessed the likelihood women an initial diagnosis WCH developing pre‐eclampsia (PE) as their progressed. Design Prospective observational study. Setting St George Hospital, teaching University hospital. Population Two hundred forty‐one pregnant early essential (EH). Methods Eighty‐six...

10.1111/j.1471-0528.2004.00516.x article EN BJOG An International Journal of Obstetrics & Gynaecology 2005-01-12
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