Hannele Laivuori
A5035957107- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
- Maternal and fetal healthcare
- Infant Development and Preterm Care
- Genetic Associations and Epidemiology
- Cardiovascular Issues in Pregnancy
- Bariatric Surgery and Outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Adolescent and Pediatric Healthcare
- Neurological Complications and Syndromes
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Folate and B Vitamins Research
- Ovarian function and disorders
- Complement system in diseases
- Hip disorders and treatments
- Hemoglobinopathies and Related Disorders
- Cancer-related molecular mechanisms research
- Blood Coagulation and Thrombosis Mechanisms
University of Helsinki
2016-2025
Tampere University
2017-2025
Institute for Molecular Medicine Finland
2016-2025
Helsinki University Hospital
2016-2025
Tampere University Hospital
2017-2025
Finland University
2015-2025
Pirkanmaa Hospital District
2024-2025
HiLIFE – Elämäntieteiden Instituutti
2024
Polish Mother’s Memorial Hospital Research Institute
2023
Inserm
2023
Abstract Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These survived the founding bottleneck rather than being distributed over large ultrarare variants. Although this effect is well established Mendelian genetics, its value common disease genetics less explored 1,2 . FinnGen aims to study genome and national health register data...
OBJECTIVE To assess whether gestational diabetes mellitus (GDM) can be prevented by a moderate lifestyle intervention in pregnant women who are at high risk for the disease. RESEARCH DESIGN AND METHODS Two hundred ninety-three with history of GDM and/or prepregnancy BMI ≥30 kg/m2 were enrolled study &lt;20 weeks gestation and randomly allocated to group (n = 155) or control 138). Each subject received individualized counseling on diet, physical activity, weight from trained nurses, had...
ABSTRACT Population isolates such as Finland provide benefits in genetic studies because the allelic spectrum of damaging alleles any gene is often concentrated on a small number low-frequency variants (0.1% ≤ minor allele frequency < 5%), which survived founding bottleneck, opposed to being distributed over much larger ultra--rare variants. While this advantage well-- established Mendelian genetics, its value common disease genetics has been less explored. FinnGen aims study genome and...
Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with accurately estimate chronological in children adults. In the current study, we examine whether cord blood can gestational at birth. We find that estimated from of neonatal spot samples. calculate using 148 CpG sites selected through elastic net regression six training datasets. evaluate predictive accuracy nine testing...
Significance Prenatal stress exposure is associated with a wide range of health problems later in life. This may be mediated part via glucocorticoid (GC) during fetal development known to impact neurogenesis and induce epigenetic changes. Using human hippocampal progenitor cell line assess the effects GCs, we observe that GCs early results lasting changes DNA methylation (DNAm). Lasting DNAm alterations are significantly enhanced transcriptional response subsequent GC exposure. Our data...
Abstract Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses 141 species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10 −8 ), 10 which associate risk including five new loci- COL5A1 , GLTPD2 SPTLC3 MBOAT7 GALNT16 (false...
A genetic contribution to preeclampsia susceptibility has been established but is still incompletely understood.To disentangle the underlying architecture of and or other maternal hypertension during pregnancy with a genome-wide association study (GWAS) hypertensive disorders pregnancy.This GWAS included meta-analyses in combination phenotype encompassing disorders. Two overlapping groups were selected for examination, namely, pregnancy. Data from Finnish Genetics Pre-eclampsia Consortium...
Preeclampsia remains a major problem worldwide for mothers and babies. Despite intensive study, we have not been able to improve the management or early recognition of preeclampsia. At least part this is because failure standardize approach studying complex syndrome. It possible that within syndrome there may be different phenotypes with pathogenic pathways differ between subtypes. The capacity recognize exploit subtypes obvious importance prediction, prevention, treatment. We present...
Abstract Polygenic risk scores (PRS) for breast cancer have potential to improve prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women the FinnGen study with 8401 cases, PRS modifies of two high-impact frameshift variants. Similarly, after diagnosis, individuals elevated an developing contralateral cancer, and can considerably assessment female first-degree relatives. In more detail, c.1592delT variant PALB2...
Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed genome-wide association study (GWAS) for unrelated Australian individuals Caucasian ancestry using Illumina OmniExpress-12 BeadChip to successfully genotype 648,175 SNPs 538 cases and 540 normal pregnancy controls. Two SNP associations (rs7579169, p = 3.58×10(-7), OR 1.57; rs12711941, 4.26×10(-7), 1.56) satisfied our significance threshold (modified Bonferroni p<5.11×10(-7)). These...
Abstract Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either or contributions DNAm, few assessed their integrated effects. Here we examine relative prenatal genotype on in neonatal blood at variably methylated regions (VMRs) 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion test which best explain...
Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, additive influences remain unclear.A total 2,231 mothers the Prediction Prevention Pre-eclampsia Intrauterine Growth Restriction (PREDO) study completed Center for Epidemiological Studies Depression Scale biweekly up to 14 times twice 12 months pregnancy. At child's age 1.9-5.7 years, Beck Inventory-II on their concurrent Ages Stages Questionnaire...