A5027048775- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Maternal and fetal healthcare
- Pregnancy-related medical research
- Gestational Diabetes Research and Management
- Neonatal and fetal brain pathology
- Cardiovascular Issues in Pregnancy
- Maternal and Perinatal Health Interventions
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Blood Coagulation and Thrombosis Mechanisms
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Neuropeptides and Animal Physiology
- Renal and related cancers
- Electrolyte and hormonal disorders
- Tissue Engineering and Regenerative Medicine
- Neuroendocrine regulation and behavior
- Assisted Reproductive Technology and Twin Pregnancy
- Neuroscience of respiration and sleep
- Folate and B Vitamins Research
Royal Women's Hospital
2016-2025
The University of Melbourne
2016-2025
RMIT University
2025
Royal Ottawa Mental Health Centre
2000-2024
Royal Children's Hospital
1999-2017
Monash University
1988-2017
Murdoch Children's Research Institute
2017
Sunshine Hospital
2017
Western Health
2017
UNSW Sydney
2017
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset preeclampsia, but its predictive value with suspected preeclampsia unclear.We performed a prospective, multicenter, observational study derive and validate serum sFlt-1 PlGF that would be absence or presence short term singleton pregnancies whom was (24 weeks 0 days 36 6 gestation). Primary objectives were assess whether low sFlt-1:PlGF ratios (at...
Elucidating the genetic architecture of preeclampsia is a major goal in obstetric medicine. We have performed genome-wide association study (GWAS) for unrelated Australian individuals Caucasian ancestry using Illumina OmniExpress-12 BeadChip to successfully genotype 648,175 SNPs 538 cases and 540 normal pregnancy controls. Two SNP associations (rs7579169, p = 3.58×10(-7), OR 1.57; rs12711941, 4.26×10(-7), 1.56) satisfied our significance threshold (modified Bonferroni p<5.11×10(-7)). These...
ABSTRACT Objectives The soluble fms‐like tyrosine kinase‐1 (sFlt‐1) to placental growth factor (PlGF) ratio is generally elevated some time before and at the clinical onset of pre‐eclampsia. PROGNOSIS study validated a sFlt‐1/PlGF cut‐off ≤ 38 rule out pre‐eclampsia within 1 week testing in women with suspected disease. aim this was assess predictive value for up 4 weeks, repeat measurements. Methods This an exploratory post‐hoc analysis data from performed pregnant aged ≥ 18 years...
Background: Although policymakers have suggested that improving continuity of midwifery can increase women's satisfaction with care in childbirth, evidence based on randomized controlled trials is lacking. New models care, such as birth centers and team midwife try to the caregiver. The objective this study was evaluate effect a new program standard clinic hospital environment antenatal, intrapartum, postpartum low‐risk women early pregnancy. Methods: Women at Royal Women's Hospital...
To estimate the association between five commonly inherited thrombophilia polymorphisms and adverse pregnancy outcomes in women who had no prior history of or personal family venous thromboembolism.Healthy nulliparous (n=2,034) were recruited to this prospective cohort study before 22 weeks gestation. Genotyping for factor V Leiden, prothrombin gene mutation, methylenetetrahydrofolate reductase enzyme (MTHFR) C677T, MTHFR A1298C, thrombomodulin polymorphism was performed. Clinicians caring...
The efflux pump ATP binding cassette superfamily member G2 (ABCG2)/breast cancer resistance protein (BCRP) is highly expressed in human placenta. We have investigated the role of BCRP protection placental trophoblasts from apoptosis and its expression idiopathic fetal growth restriction, a condition associated with abnormal apoptosis. Inhibition activity selective inhibitor Ko143 augmented cytokine (tumor necrosis factor-alpha/interferon-gamma)-induced phosphatidylserine externalization...
OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio greater than 38 with time to delivery and preterm birth. METHODS: Secondary analysis an observational cohort study that included women 18 years age or older from 24 36 6/7 weeks gestation at their first visit suspected (not confirmed) preeclampsia. Participants were recruited December 2010 January 2014 30 sites in 14 countries. A total 1,041 time-to-delivery...
Objective To identify effects on health outcomes from implementing new criteria diagnosing gestational diabetes mellitus(GDM) and to analyse costs-of-care associated with this change. Design Quasi-experimental study comparing data the calendar year before (2014) after (2016) Setting Single, tertiary-level, university-affiliated, maternity hospital. Participants All women giving birth in hospital, excluding those pre-existing or multiple pregnancy. Main outcome measures Primary were caesarean...
Pre-eclampsia is a serious complication of the second half human pregnancy which occurs at frequencies 1 % to 5% in most parts world. It characterized clinically by high blood pressure, proteinuria, and generalized edema association with wide range pathophysiological organ system disturbances. Untreated, it can lead occurrence epileptic-like grand-mal convulsions (eclampsia), source considerable maternal fetal morbidity. The disease unusual having no known cause, although an immunological...