A5083920789- Epigenetics and DNA Methylation
- Developmental Biology and Gene Regulation
- Pain Mechanisms and Treatments
- Pancreatic function and diabetes
- Birth, Development, and Health
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- Healthcare and Venom Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Ubiquitin and proteasome pathways
- Ion Channels and Receptors
- Cancer Mechanisms and Therapy
- Neuropeptides and Animal Physiology
- Chromatin Remodeling and Cancer
- Galectins and Cancer Biology
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Chromosomal and Genetic Variations
- Histone Deacetylase Inhibitors Research
- Plant-based Medicinal Research
- Neonatal Respiratory Health Research
United Arab Emirates University
2015-2025
Zayed University
2020-2024
Singapore Institute for Clinical Sciences
2011
Gateshead Health NHS Foundation Trust
2011
Queen Elizabeth Hospital
2011
Hull York Medical School
2011
University of Auckland
2005-2008
University of Otago
2006
European Molecular Biology Laboratory
2004
Centre for Cellular and Molecular Biology
2000-2004
Fixed genomic variation explains only a small proportion of the risk adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate humans.Using Sequenom MassARRAY we measured methylation status 68 CpGs 5' from five candidate genes umbilical cord tissue DNA healthy neonates. Methylation varied greatly at particular CpGs: for 31 with median ≥5% and 5-95% range...
Prolonged, moderate cerebral hypothermia is consistently neuroprotective after experimental hypoxia-ischaemia; however, it has not been tested in the preterm brain. Preterm (0.7 gestation) fetal sheep received complete umbilical cord occlusion for 25 min followed by (fetal extradural temperature reduced from 39.4 +/- 0.3 to 29.5 2.6 degrees C) 90 70 h end of or sham cooling. Occlusion led severe acidosis and profound hypotension, which recovered rapidly release occlusion. After 3 days...
The efflux pump ATP binding cassette superfamily member G2 (ABCG2)/breast cancer resistance protein (BCRP) is highly expressed in human placenta. We have investigated the role of BCRP protection placental trophoblasts from apoptosis and its expression idiopathic fetal growth restriction, a condition associated with abnormal apoptosis. Inhibition activity selective inhibitor Ko143 augmented cytokine (tumor necrosis factor-alpha/interferon-gamma)-induced phosphatidylserine externalization...
Abstract Obesity is a multifactorial disease that part of today's epidemic and also increases the risk other metabolic diseases. Long noncoding RNAs (lncRNAs) provide one tier regulatory mechanisms to maintain homeostasis. Although lncRNAs are significant constituent mammalian genome, studies aimed at their significance, including obesity, only beginning be addressed. Here, developmentally regulated lncRNA, termed as obesity related (Obr), whose expression in metabolically relevant tissues...
Legs and antennae are considered to be homologous appendages. The fundamental patterning mechanisms that organize spatial pattern conserved,yet appendages with very different morphology develop. A genetic hierarchy for specification of antennal identity has been partly elucidated. We report identification a novel family genes roles in development. distal antenna (dan) antenna-related(danr) encode nuclear proteins expressed the presumptive antenna, but not leg imaginal disc. Ectopic...
Diabetes mellitus is a chronic disease that impairs metabolism, and its prevalence has reached an epidemic proportion globally. Most people affected are with type 2 diabetes (T2DM), which caused by decline in the numbers or functioning of pancreatic endocrine islet cells, specifically β-cells release insulin sufficient quantity to overcome any resistance metabolic tissues. Genetic epigenetic factors have been implicated as main contributors T2DM. Epigenetic modifiers, histone deacetylases...
The nutrient responsive O-GlcNAcylation is a dynamic post-translational protein modification found on several nucleocytoplasmic proteins. Previous studies have suggested that hyperglycemia induces the levels of total inside cells. Hyperglycemia mediated increase in has been shown to be responsible for various pathologies including insulin resistance and Alzheimer's disease. Since maternal during pregnancy associated with adverse neurodevelopmental outcomes offspring, it intriguing identify...
Aging is a complex biological process marked by the decline of physiological functions and heightened susceptibility to chronic illnesses, notably cardiometabolic disorders. Ceramides (Cer) are lipid derivatives linked aging metabolic diseases. Sodium-Glucose Cotransporter-2 inhibitors (SGLT2i), widely used in managing type 2 diabetes, have an unclear impact on biomarkers Cer profiles. This study explored association between SGLT2i use, plasma levels (CerC16:0, CerC18:0, CerC22:0, CerC24:0,...
We have exploited a discrepancy in the oncogenic potential of autocrine and exogenous human growth hormone (hGH) an attempt to identify molecules that could potentially be involved transformation mammary epithelial cell. Microarray analysis 19,000 genes identified subset 305 carcinoma cell line were remarkably different their response hGH. Autocrine hGH also regulated 167 common genes. Semiquantitative reverse transcription-PCR confirmed differential regulation by either or Functional one...
Context: Hyperlipidemia is known to be a major risk factor for the development of cardiovascular diseases (CVDs) which include atherosclerosis, coronary heart disease, and stroke. Although there are large number anti-hyperlipidemic drugs available, unfortunately, they all have side effects.Objective: Terminalia chebula Retz. (Combretaceae) plant used treat cardiac disorders in traditional Ayurveda medicine India. The objective this study was assess properties methanol (MeOH) bark extract T....
We have previously demonstrated that the p44/42 MAPK pathway is one involved in homeobox (HOX) A1-stimulated oncogenesis. However, inhibition of kinase 1 does not completely prevent HOXA1-stimulated oncogenic transformation, suggesting involvement additional signal transduction pathways. Here, we report forced expression HOXA1 immortalized human mammary epithelial cells significantly increased levels transducer and activator transcription (STAT) 3, 5A, 5B mRNA by transcriptional...