A5048448147- Pregnancy and preeclampsia studies
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Electrospun Nanofibers in Biomedical Applications
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Genetic Syndromes and Imprinting
- Pluripotent Stem Cells Research
- Cancer-related gene regulation
- Gestational Diabetes Research and Management
- Alzheimer's disease research and treatments
- Developmental Biology and Gene Regulation
- Preterm Birth and Chorioamnionitis
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
Royal Women's Hospital
2015-2024
The University of Melbourne
2014-2024
The University of Adelaide
1981-2008
The University of Western Australia
2008
Heidelberg Repatriation Hospital
2006
Flinders University
1994-2003
University of Vienna
2000
University of Alberta
2000
Scripps Research Institute
2000
University of South Australia
1994-1998
A successful pregnancy depends on the intricate and timely interactions of maternal fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo partial (EMT) when differentiating into gain capacity migrate invade. This review summarizes our current knowledge regarding known regulators EMT in human placenta, including inducers EMT, upstream transcription factors that control...
Abstract Accumulating evidence indicates that abnormal deposition of amyloid‐β (Aβ) peptide in the brain is responsible for endothelial cell damage and consequently leads to blood–brain barrier ( BBB ) leakage. However, mechanisms underlying disruption are not well described. We employed an monolayer model comprising bE nd.3 found leakage was induced by treatment with Aβ 1–42, levels tight junction TJ scaffold proteins ZO ‐1, Claudin‐5, Occludin) were decreased. Through comparisons effects...
We reported the identification of a new family DNA-binding proteins from our characterization dead ringer (dri) gene Drosophila melanogaster. show that dri encodes nuclear protein contains sequence-specific domain bears no similarity to known domains. A number were found contain sequences homologous this domain. Other containing conserved motif include yeast SWI1, two human retinoblastoma binding proteins, and other mammalian regulatory proteins. mouse B-cell-specific regulator exhibits 75%...
The efflux pump ATP binding cassette superfamily member G2 (ABCG2)/breast cancer resistance protein (BCRP) is highly expressed in human placenta. We have investigated the role of BCRP protection placental trophoblasts from apoptosis and its expression idiopathic fetal growth restriction, a condition associated with abnormal apoptosis. Inhibition activity selective inhibitor Ko143 augmented cytokine (tumor necrosis factor-alpha/interferon-gamma)-induced phosphatidylserine externalization...
The aim of the study was to investigate effect icariin (ICA) on cardiac aging through its effects SIRT6 enzyme and NF- κ B pathway. Investigating ICA enzymatic activity histone deacetylase revealed a concentration 10 −8 mol/L had maximum activating activity. Western analysis showed that upregulated protein expression downregulated (p65) in animal tissues cell models. an inhibitory inflammatory signaling pathways as shown by decreasing mRNA levels downstream target genes TNF- α , ICAM-1,...
Iron deposition in the brain is an early issue Alzheimer's disease (AD). However, pathogenesis of iron-induced pathological changes AD remains elusive. Insulin resistance brains essential feature AD. Previous studies determined that insulin involved development pathologies Tau pathology one most important hallmarks and associated with impairment cognition clinical grades disease. In present study, we observed ferrous (Fe2+) chloride led to aberrant phosphorylation tau, decreased tyrosine...
Mesenchymal stem cell (MSC) therapies for the treatment of diseases associated with inflammation and oxidative stress employ primarily bone marrow MSCs (BMMSCs) other MSC types such as from chorionic villi human term placentae (pMSCs). These are not derived microenvironments stress, unlike decidua basalis placenta (DBMSCs). DBMSCs were isolated then extensively characterized. Differentiation into three mesenchymal lineages (adipocytes, osteocytes, chondrocytes) was performed. Real‐time...