A5068456388- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Barrier Structure and Function Studies
- Peripheral Neuropathies and Disorders
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- S100 Proteins and Annexins
- Parkinson's Disease Mechanisms and Treatments
- Mesenchymal stem cell research
- Antifungal resistance and susceptibility
- GDF15 and Related Biomarkers
- Myasthenia Gravis and Thymoma
- Wnt/β-catenin signaling in development and cancer
- Complement system in diseases
- Computational Drug Discovery Methods
- Neurological disorders and treatments
- Heat shock proteins research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diabetic Foot Ulcer Assessment and Management
- Heavy Metal Exposure and Toxicity
- Intracranial Aneurysms: Treatment and Complications
- Sirtuins and Resveratrol in Medicine
- Pluripotent Stem Cells Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Ship Hydrodynamics and Maneuverability
Shanghai Jiao Tong University
2018-2025
Renji Hospital
2018-2024
Fudan University
2013-2019
Zhongshan Hospital
2014-2019
State Key Laboratory of Medical Neurobiology
2019
Sun Yat-sen University
2014-2018
The First Affiliated Hospital, Sun Yat-sen University
2014-2018
Naval University of Engineering
2015
Huadong Hospital
2014
Affiliated Hospital of Zunyi Medical College
2004-2009
Growing evidence has indicated that iron deposition in the substantia nigra (SN) plays an important role Parkinson's disease (PD). However, underlying mechanism is still elusive. Using primary dopaminergic neurons and SH-SY5Y cells cultured vitro, we observed loading increased α-synuclein reactive oxygen species (ROS) levels these but did not affect intracellular mRNA levels. Furthermore, significantly downregulated Beclin-1 decreased ratio of microtubule-associated protein 1 light chain 3...
Abstract Accumulating evidence indicates that abnormal deposition of amyloid‐β (Aβ) peptide in the brain is responsible for endothelial cell damage and consequently leads to blood–brain barrier ( BBB ) leakage. However, mechanisms underlying disruption are not well described. We employed an monolayer model comprising bE nd.3 found leakage was induced by treatment with Aβ 1–42, levels tight junction TJ scaffold proteins ZO ‐1, Claudin‐5, Occludin) were decreased. Through comparisons effects...
Neuromelanin of the brainstem, which is considered a marker neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate NM-MRI features de novo PD and determine whether these are associated with motor non-motor symptoms patients.Fifty-one patients (Hoehn Yahr stage 1-2) 28 healthy controls were recruited. All subjects underwent clinical MRI examinations including an sequence. The width...
Iron deposition in the brain is an early issue Alzheimer's disease (AD). However, pathogenesis of iron-induced pathological changes AD remains elusive. Insulin resistance brains essential feature AD. Previous studies determined that insulin involved development pathologies Tau pathology one most important hallmarks and associated with impairment cognition clinical grades disease. In present study, we observed ferrous (Fe2+) chloride led to aberrant phosphorylation tau, decreased tyrosine...
Alzheimer's disease (AD) is the most common form of senile dementia which characterized by abnormal amyloid beta (Aβ) accumulation and deposition in brain parenchyma cerebral capillaries, leads to blood-brain barrier (BBB) disruption. Despite great progress understanding etiology AD, underlying pathogenic mechanism BBB damage still unclear, no effective treatment has been devised. The standard Ginkgo biloba extract EGb761 widely used as a potential cognitive enhancer for AD. However,...
The objective of the present study was to investigate optimal culture requirements for mycelial growth and exopolysaccharide production by Cordyceps jiangxiensis JXPJ 0109 in submerged culture.The effects medium ingredients (i.e. carbon nitrogen sources, factor) other initial pH, temperature, etc.) on mycelia were observed using a one-factor-at-a-time method. More suitable proved be maltose, glycerol, tryptone, soya bean steep powder, yeast extract, capacity 200 ml 500-ml flask, agitation...
Autoimmune encephalitis (AE) is a group of disorders characterized by antibodies targeting neuronal cell surface, intracellular structures and synapse antigens. Treatment for AE involves reducing antibody levels suppressing immune-mediated inflammation using intravenous immunoglobulin, plasma exchange (PE), immune-modulating agents. PE commonly used in autoimmune neurological diseases, but the safety issues are worth continuous attention. This case report describes 28-year-old patient who...
Alzheimer's disease (AD) is the most common type of dementia and has no effective therapies. Previous studies showed that bone morphogenetic protein 9 (BMP9), an important factor in differentiation phenotype maintenance cholinergic neurons, ameliorated defects resulting from amyloid deposition. These findings suggest BMP9 potential as a therapeutic agent for AD. However, effects on cognitive function AD its underlying mechanisms remain elusive. In present study, was delivered intranasally to...