A5033650991- Fungal Biology and Applications
- Mesenchymal stem cell research
- Polysaccharides and Plant Cell Walls
- Proteoglycans and glycosaminoglycans research
- Microbial Natural Products and Biosynthesis
- Phytochemistry and Bioactivity Studies
- Chemical synthesis and alkaloids
- Osteoarthritis Treatment and Mechanisms
- Corneal Surgery and Treatments
- Medicinal plant effects and applications
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Diabetes and associated disorders
- Mycorrhizal Fungi and Plant Interactions
- Tissue Engineering and Regenerative Medicine
- Genomics, phytochemicals, and oxidative stress
- Gut microbiota and health
- Diabetes Management and Research
- Telomeres, Telomerase, and Senescence
- Wnt/β-catenin signaling in development and cancer
- Acute Kidney Injury Research
- Ocular Surface and Contact Lens
- Circadian rhythm and melatonin
- Medicinal Plants and Bioactive Compounds
- MicroRNA in disease regulation
Zunyi Medical University
2014-2025
Shenzhen Pingle Orthopedic Hospital
2024
Shenzhen Second People's Hospital
2024
Jiangxi Agricultural University
2019-2023
Sun Yat-sen Memorial Hospital
2009-2023
Sun Yat-sen University
2009-2023
Henan Institute of Geological Survey
2022
Syngenta (China)
2019
University of Glasgow
2015
Affiliated Hospital of Zunyi Medical College
2004-2014
WRKY transcription factors play important roles in response to various abiotic stresses. Previous study have proved that soybean GmWRKY54 can improve stress tolerance transgenic Arabidopsis. Here, we generated plants and further investigated biological mechanisms of drought stress. We demonstrated expression GmWRKY54, driven by either a constitutive promoter (pCm) or drought-induced (RD29a), confers tolerance. is transcriptional activator affects large number stress-related genes as revealed...
Abstract Stem cell senescence is an important cause of aging. Delaying may present a novel way to combat aging and age‐associated diseases. This study provided mechanistic insight into the protective effect ganoderic acid D (GA‐D) against human amniotic mesenchymal stem (hAMSCs) senescence. GA‐D, Ganoderma lucidum ‐derived triterpenoid, markedly prevented hAMSCs via activating Ca 2+ calmodulin (CaM)/CaM‐dependent protein kinase II (CaMKII)/nuclear erythroid 2‐related factor 2 (Nrf2) axis,...
Cordyceps taii , an edible medicinal mushroom native to south China, is recognized as unparalleled resource of healthy foods and drug discovery. In the present study, antioxidant pharmacological properties C. were systematically investigated. vitro assays revealed scavenging activities aqueous extract polysaccharides against various free radicals, that is, 1,1-diphenyl-2-picrylhydrazyl radical, hydroxyl superoxide anion radical. The EC 50 values for anion-free radical ranged from 2.04 mg/mL...
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by high levels of proinflammatory cytokines and epithelial barrier dysfunction. The root Ligularia fischeri (Ledeb.) Turcz. traditional Chinese medicinal herb with diverse therapeutic properties, which has been successfully used to treat inflammation-related diseases. However, little known about its effect mechanism against UC.To investigate the efficacy L. extracts UC.L. samples were prepared using alcohol...
The objective of the present study was to investigate optimal culture requirements for mycelial growth and exopolysaccharide production by Cordyceps jiangxiensis JXPJ 0109 in submerged culture.The effects medium ingredients (i.e. carbon nitrogen sources, factor) other initial pH, temperature, etc.) on mycelia were observed using a one-factor-at-a-time method. More suitable proved be maltose, glycerol, tryptone, soya bean steep powder, yeast extract, capacity 200 ml 500-ml flask, agitation...
Abstract To evaluate the possible antiaphid function of Amaranthus caudatus agglutinin (ACA) in allogenetic plants, transgenic cotton plants expressing ACA gene under control a phloem‐specific promoter were generated via Agrobacterium ‐mediated transformation. Based on results Southern blot analyses, six with single or lower copy transgene and favourable agronomic traits selected for further studies. expression levels ranged from 0.02% to 0.45% total soluble protein as determined by Western...
Osteoarthritis (OA) is one of the most common but refractory degenerative articular cartilage diseases. The emerging human amniotic mesenchymal cells (hAMSCs) have been identified a promising stem cell source in repair, and hyaluronic acid (HA) versatile regulator for transplantation. Herein, an effective straightforward intra-articular injection therapy using cocktail hAMSCs HA developed to treat knee OA rat model. injured remarkably regenerated very close level normal after 56 days...
Hyperglycemia and dyslipidemia are classic features of patients with diabetes mellitus (DM). Cordyceps taii, a folk medicinal fungus native to southern China, possesses various pharmacological activities. This study aimed assess the glucose-lowering hypolipidemic effects polysaccharides from C. taii (CTP) in streptozotocin (STZ)-induced diabetic mice. Kunming mice were intraperitoneally injected STZ at dose 100 mg/kg body weight. After induction diabetes, randomly divided into five groups:...
Aging is an important risk factor in the occurrence of many chronic diseases. Senescence and exhaustion adult stem cells are considered as a hallmark aging organisms. In this study, senescent human amniotic mesenchymal cell (hAMSC) model subjected to oxidative stress was established vitro using hydrogen peroxide. We investigated effects ganoderic acid D (GA-D), natural triterpenoid compound produced from Ganoderma lucidum , on hAMSC senescence. GA-D significantly inhibited β -galactosidase...
Osteogenic inducers play central roles in effective stem cell-based treatment of bone defects/losses. However, the current routine osteogenic inducer is a cocktail comprising three components that must be improved due to low induction efficiency and side effects. Therefore, there an urgent need develop safer more osteoinducers. Herein, we demonstrated effect Ganoderal A (GD-A), tetracyclic triterpenoid compound from Ganoderma lucidum. GD-A showed no cytotoxicity toward human amniotic...
A novel isolate, designated strain MCCC 1A01535T, belonging to the genus Streptomyces was isolated from rhizosphere of mangrove plant Avicennia mariana Fujian Province, south China. Characterization isolate based on a polyphasic approach. Pairwise comparison 16S rRNA gene sequences revealed that 1A01535T shared 97.7 and 97.5 % sequence similarities specialis GW41-1564T hainanensis YIM47672T, respectively, its most closely related neighbours, whereas DNA–DNA relatedness value between strains...