A5101537564- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological and metabolic disorders
- Alcoholism and Thiamine Deficiency
- Genetic Neurodegenerative Diseases
- Folate and B Vitamins Research
- RNA regulation and disease
- Alzheimer's disease research and treatments
- Alkaloids: synthesis and pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrovascular and Carotid Artery Diseases
- Infectious Encephalopathies and Encephalitis
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- RNA Research and Splicing
- Biochemical Acid Research Studies
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Frailty in Older Adults
- Genetic Associations and Epidemiology
- Parvovirus B19 Infection Studies
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Bullous Skin Diseases
Sun Yat-sen University
2015-2025
The First Affiliated Hospital, Sun Yat-sen University
2015-2025
Zhongshan Hospital
2015-2024
Fudan University
2015-2024
State Key Laboratory of Medical Neurobiology
2015-2021
Shanghai Medical College of Fudan University
2008-2019
Washington University in St. Louis
2017
Institute of Neurobiology
2015
Research Institute of Semiconductor Devices
2005
Growing evidence has indicated that iron deposition in the substantia nigra (SN) plays an important role Parkinson's disease (PD). However, underlying mechanism is still elusive. Using primary dopaminergic neurons and SH-SY5Y cells cultured vitro, we observed loading increased α-synuclein reactive oxygen species (ROS) levels these but did not affect intracellular mRNA levels. Furthermore, significantly downregulated Beclin-1 decreased ratio of microtubule-associated protein 1 light chain 3...
In vivo and post-mortem studies have demonstrated that increased nigral iron content in patients with Parkinson's disease is a prominent pathophysiological feature. However, the mechanism risk factors associated deposition not been identified represent key challenge understanding its pathogenesis for diagnosis. this study, we assessed levels age- gender-matched control subjects by measuring phase values using magnetic resonance based susceptibility-weighted imaging 3T system. Phase were...
Neuromelanin of the brainstem, which is considered a marker neurodegeneration in Parkinson's disease (PD), can be detected by T1-weighted neuromelanin-sensitive magnetic resonance imaging (NM-MRI). Our aim was to investigate NM-MRI features de novo PD and determine whether these are associated with motor non-motor symptoms patients.Fifty-one patients (Hoehn Yahr stage 1-2) 28 healthy controls were recruited. All subjects underwent clinical MRI examinations including an sequence. The width...
<b>BACKGROUND AND PURPOSE:</b> Nonalcoholic Wernicke encephalopathy (WE) is prone to be underestimated in clinical practice. The purpose of this study was improve its awareness and early accurate diagnosis. <b>Materials METHODS:</b> We conducted a retrospective review the cases 12 patients with nonalcoholic WE, consisting characteristics MR imaging features as well follow-up after administration thiamine. <b>RESULTS:</b> Patients mild coma or lethargy (7/12) exhibited typical symmetric brain...
Brain glucose hypometabolism is an invariant feature and has significant diagnostic value for Alzheimer's disease. Thiamine diphosphate (TDP) a critical coenzyme metabolism significantly reduced in brain blood samples of patients with disease (AD).To explore the measurement thiamine metabolites AD.Blood TDP, monophosphate, levels were detected using high performance liquid chromatography (HPLC). The study included exploration validation phases. In phase, 338 control subjects 43 AD utilized...
Abstract Background We aimed to investigate neuromelanin‐sensitive magnetic resonance imaging (NM‐MRI) features in the locus coeruleus of de novo Parkinson's disease patients with different cognitive states and determine whether these are associated impairment. Methods Three groups subjects were recruited this study, including PD mild impairment (n = 23), without 48), control 32). All underwent clinical evaluations, as well MRI scanning. The contrast‐to‐noise ratio images cortical thickness...
The underlying mechanism of brain glucose hypometabolism, an invariant neurodegenerative feature that tightly correlates with cognitive impairment and disease progression Alzheimer's (AD), remains elusive.Positron emission tomography 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) was used to evaluate metabolism, presented as the rate standardized uptake value ratio (FDG SUVR) in patients AD or control subjects mice without thiamine deficiency induced by a thiamine-deprived diet. Brain amyloid-β...
Differentiating early-stage Parkinson's disease (PD) from essential tremor (ET) remains challenging. In the current study, we aimed to evaluate whether visual analyses of neuromelanin-sensitive magnetic resonance imaging (NM-MRI) combined with nigrosome-1 (N1) using quantitative susceptibility mapping (QSM) in substantia nigra (SN) are diagnostic value differentiation de novo PD untreated ET. Sixty-eight patients PD, 25 ET, and 34 control participants underwent NM-MRI QSM. NM N1 signals SN...
Background and purpose: To investigate whether brain iron deposition correlates with motor phenotypic expressions of Parkinson’s disease. Methods: We subtyped patients disease according to their main symptoms (tremor, rigidity/bradykinesia) into three subgroups: tremor‐dominant subgroup, akinetic/rigid‐dominant or mixed subgroup. The levels in bilateral substantia nigra, globus pallidus, putamen, the head caudate, red nucleus 87 50 control subjects were assayed by measuring phase values...
Alzheimer's disease (AD) is a complicated, neurodegenerative disorder involving multifactorial pathogeneses and still lacks effective clinical treatment. Recent studies show that lithium exerts disease-modifying effects against AD. However, the intolerant side at conventional dosage limit use of in treating To explore novel AD treatment strategy with microdose lithium, we designed synthesized new chemical, tri-lithium pyrroloquinoline quinone (Li3PQQ), to study synergistic low-dose quinone,...
Nephrotic syndrome (NS) occurs in 5-15% of patients with IgA nephropathy (IgAN), resulting poorer long-term outcomes compared to those without NS. Clinical features and renal prognosis for both NS IgAN across different kidney pathologies have not been fully elucidated. This study included primary through biopsy at the First Affiliated Hospital Sun Yat-sen University from January 2001 November 2021 presenting Renal endpoint was defined as a 50% decrease estimated glomerular filtration rate or...
Cognitive impairment is a common non-motor symptom in Parkinson's disease (PD), with executive dysfunction being an initial manifestation. We aimed to investigate whether and how longitudinal changes the prefrontal perfusion correlate mild cognitive (MCI) patients PD. recruited 49 PD normal cognition 37 matched healthy control subjects (HCs). Patients completed arterial spin labeling MRI (ASL–MRI) scans comprehensive battery of neuropsychological assessments at baseline (V0) 2-year follow-up...
Background Thiamine metabolites and activities of thiamine-dependent enzymes are impaired in Alzheimer's disease (AD). Objective To clarify the mechanism for reduction thiamine diphosphate (TDP), an active form critical coenzyme glucose metabolism, AD. Methods Forty-five AD patients clinically diagnosed 38 age- gender-matched control subjects without dementia were voluntarily recruited. The contents blood TDP, monophosphate (TMP), thiamine, as well diphosphatase (TDPase), monophosphatase...
Maintaining and manipulating sequences online is essential for daily activities such as scheduling a day. In Parkinson9s disease (PD), sequential working memory deficits have been associated with altered regional activation functional connectivity in the basal ganglia. This study demonstrates that substantia nigra (SN) integrity correlated ganglia function sequencing performance 29 patients PD (17 women) healthy controls (HCs; 18 women). neuromelanin-sensitive structural magnetic resonance...
The perioperative efficacy and safety of efgartigimod in patients with thymoma associated myasthenia gravis have not been reported.
Objectives Thiamine diphosphate (TDP) is an indispensable coenzyme for three key enzymes in glucose metabolism. Reduced TDP levels patients with Alzheimer's disease (AD) has been widely demonstrated and a diagnostic biomarker the disease. In this study, we further explored correlation between altered metabolism AD along other risk factors. Methods A 1:1 case-control study was employed 90 control subjects normal-range cognitive abilities as assayed by Mini Mental Status Evaluation. Age (≤2...
This study aims to develop a new evaluation method for quickly and conveniently screening cognitive impairment in the elderly. The five-minute test (FCT) was designed capture deficits five domains of abilities, including episodic memory, language fluency, time orientation, visuospatial function, executive function. Subsequently, FCT efficiencies differentiating normally ability from were explored compared with that Mini-Mental Status Evaluation (MMSE). Equipercentile equating utilized create...
Isolated mitochondrial myopathy refers to the condition of disorders that primarily affect skeletal muscle system. Here we report on a case patient who presented with acute respiratory failure as initial and predominant clinical manifestation after using anesthetic drugs. The diagnosis was made by histochemical findings ragged red fibers modified Gomori trichrome Stain in biopsy genetic detection an A3243G point mutation tRNALeu (UUR) gene DNA (mtDNA) peripheral blood specimen. revealed...
Objectives: Freezing of gait (FOG) is generally considered as an independent symptom Parkinson's disease (PD) with a complex pathophysiology. There wide range associated clinical features FOG reported from different studies without consistent conclusion. Thus, multicenter, cross-sectional study was designed to investigate the prevalence and together its unique contribution quality life in Chinese PD patients. Methods: Eight hundred thirty eight patients were consecutively recruited into this...