A5061267996- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Maternal and fetal healthcare
- Prenatal Screening and Diagnostics
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Heart Rate Variability and Autonomic Control
- Uterine Myomas and Treatments
- Pregnancy and Medication Impact
- Medical and Health Sciences Research
- Adipokines, Inflammation, and Metabolic Diseases
- Ectopic Pregnancy Diagnosis and Management
- Neonatal and fetal brain pathology
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Cancer Risks and Factors
- Heart Failure Treatment and Management
- Pelvic floor disorders treatments
- Maternal Mental Health During Pregnancy and Postpartum
University Hospital Leipzig
2016-2025
Leipzig University
2015-2024
Schön Klinik Hamburg Eilbek
2023
Charité - Universitätsmedizin Berlin
2005-2022
Klinik und Poliklinik für Kinder- und Jugendmedizin
2020
Klinik für Frauenheilkunde
2012-2017
Medical University of Vienna
2013-2016
Roche (Switzerland)
2016
University of Liège
2016
Instituto de Salud Carlos III
2016
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset preeclampsia, but its predictive value with suspected preeclampsia unclear.We performed a prospective, multicenter, observational study derive and validate serum sFlt-1 PlGF that would be absence or presence short term singleton pregnancies whom was (24 weeks 0 days 36 6 gestation). Primary objectives were assess whether low sFlt-1:PlGF ratios (at...
Background— Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of vascular endothelial growth factor receptor 1, induces a preeclampsia-like phenotype experimental models circulates at elevated levels human preeclampsia. Removing sFlt-1 may benefit women with very preterm (<32 weeks) Methods Results— We first show that negatively charged dextran...
To establish gestational phase adapted cutoffs for the use of soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio as a diagnostic tool preeclampsia in clinical setting, multicenter case–control study including total 1149 patients was performed. We report normal values sFlt-1, PlGF, and sFlt-1/PlGF based on analysis 877 with uneventful pregnancy outcome. A 234 matched cohort consisting 468 outcome were compared, sFlt-1 PlGF measured an automated platform. Separate...
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-1 (sFlt-1) an antiangiogenic protein believed to mediate the signs and symptoms preeclampsia. We conducted open pilot study evaluate safety potential efficacy therapeutic apheresis with plasma-specific dextran sulfate column remove circulating sFlt-1 in 11 pregnant women (20–38 years age) very preterm preeclampsia (23–32 weeks gestation, systolic BP ≥140 mmHg or diastolic ≥90 mmHg, new onset...
Angiogenic factors like placental growth factor and its antiangiogenic antagonist soluble fms-like tyrosine kinase 1 (sFlt1) are closely related to the pathogenesis of preeclampsia intrauterine restriction. Because it is known that altered maternal sFlt1 levels detectable weeks before onset these pregnancy complications, was aim study investigate predictive value markers in high-risk second trimester pregnancies characterized by abnormal uterine perfusion. This prospective includes 63...
ABSTRACT Objectives The soluble fms‐like tyrosine kinase‐1 (sFlt‐1) to placental growth factor (PlGF) ratio is generally elevated some time before and at the clinical onset of pre‐eclampsia. PROGNOSIS study validated a sFlt‐1/PlGF cut‐off ≤ 38 rule out pre‐eclampsia within 1 week testing in women with suspected disease. aim this was assess predictive value for up 4 weeks, repeat measurements. Methods This an exploratory post‐hoc analysis data from performed pregnant aged ≥ 18 years...
The fetal ECG derived from abdominal leads provides an alternative to standard means of monitoring.Furthermore, it permits long-term and ambulant recordings, which expands the range diagnostic possibilities for evaluating health state.However, due temporal spectral overlap maternal signals, usage imposes need elaborated signal processing routines.In this work a modular combination techniques is presented.Its core consists two estimation techniques, namely extended Kalman smoother (EKS)...
Abnormal uterine perfusion detected by Doppler sonography reflects impaired trophoblast invasion, a factor involved in the pathogenesis of pregnancy complications such as preeclampsia or intrauterine growth retardation. Recent studies have demonstrated an autoantibody against angiotensin type 1 (AT1) receptor pregnant women with preeclampsia. Our aim was to determine whether AT1 precedes clinical symptoms and is thus predictive We therefore this antibody serum from second trimester...
OBJECTIVE: To assess the association of a serum soluble fms-like tyrosine kinase 1-to-placental growth factor (sFlt-1-to-PlGF) ratio greater than 38 with time to delivery and preterm birth. METHODS: Secondary analysis an observational cohort study that included women 18 years age or older from 24 36 6/7 weeks gestation at their first visit suspected (not confirmed) preeclampsia. Participants were recruited December 2010 January 2014 30 sites in 14 countries. A total 1,041 time-to-delivery...
Objective To evaluate the influence of soluble fms-like tyrosine kinase 1/placental growth factor ratio in physicians’ decision making pregnant women with signs and symptoms preeclampsia routine clinical practice. Methods A multicenter, prospective, open, non-interventional study enrolled presenting several European perinatal care centers. Before result was known, physicians documented intended procedures using an iPad® application (data locked/time stamped). After available, decisions were...
The aim of this official guideline published and coordinated by the German Society Gynecology Obstetrics (DGGG) was to provide consensus-based recommendations obtained evaluating relevant literature for diagnostic treatment management women with fetal growth restriction.
After delivery, some women experience impairment of their mother-infant bonding (MIB), which can lead to long-term disturbances the mother-child relationship and child's social-emotional development. Little is known about association between early maternal problems mothers' own adverse childhood experiences, even though hypothesis intergenerational transmission caregiving indicates continuity in parenting quality across generations. Therefore, current study aimed at examining maltreatment...
During pregnancy, women`s bodies undergo rapid changes in body weight and size within a relatively short period of time. Pregnancy may therefore be associated with an increased vulnerability for the development image dissatisfaction that has been linked to adverse health outcomes mother child. The present study aims examine during pregnancy as well predictors dissatisfaction. This is first using tailored, multidimensional measure especially developed pregnant population.A prospective...