Katri Räikkönen
A5010967678- Birth, Development, and Health
- Infant Development and Preterm Care
- Maternal Mental Health During Pregnancy and Postpartum
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Child and Adolescent Psychosocial and Emotional Development
- Pregnancy and preeclampsia studies
- Genetic Associations and Epidemiology
- Sleep and related disorders
- Stress Responses and Cortisol
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Genetics and Neurodevelopmental Disorders
- Health, Environment, Cognitive Aging
- Adolescent and Pediatric Healthcare
- Sleep and Wakefulness Research
- Neonatal and fetal brain pathology
- Cognitive Abilities and Testing
- Circadian rhythm and melatonin
- Child Nutrition and Feeding Issues
- Childhood Cancer Survivors' Quality of Life
- Health disparities and outcomes
- Early Childhood Education and Development
- Hormonal Regulation and Hypertension
- Cardiac Health and Mental Health
University of Helsinki
2016-2025
Helsinki University Hospital
2011-2025
Helsinki Art Museum
2000-2022
Netherlands Organisation for Health Research and Development
2021
University Medical Center
2021
National Institute for Health Research
2021
Bradford Teaching Hospitals NHS Foundation Trust
2021
Public Health Solutions
2020
Finnish Institute for Health and Welfare
2011-2020
University of Turku
2020
Aging and psychosocial stress are associated with increased inflammation disease risk, but the underlying molecular mechanisms unclear. Because both aging also lasting epigenetic changes, a plausible hypothesis is that along lifespan could confer risk through effects on molecules involved in inflammatory processes. Here, by combining large-scale analyses human cohorts experiments cells, we report FKBP5, protein implicated physiology, contributes to these relations. Across independent (total...
<h3>Importance</h3> Maternal antenatal corticosteroid treatment is standard care to accelerate fetal maturation when birth before 34 weeks imminent. Recently, expansion of the indications beyond gestational has been debated. However, data about long-term outcomes remain limited, especially among infants who after exposure are born at term. <h3>Objective</h3> To study if associated with mental and behavioral disorders in children term (≥37 0 days' gestation) preterm (<37 unmeasured...
Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with accurately estimate chronological in children adults. In the current study, we examine whether cord blood can gestational at birth. We find that estimated from of neonatal spot samples. calculate using 148 CpG sites selected through elastic net regression six training datasets. evaluate predictive accuracy nine testing...
Significance Prenatal stress exposure is associated with a wide range of health problems later in life. This may be mediated part via glucocorticoid (GC) during fetal development known to impact neurogenesis and induce epigenetic changes. Using human hippocampal progenitor cell line assess the effects GCs, we observe that GCs early results lasting changes DNA methylation (DNAm). Lasting DNAm alterations are significantly enhanced transcriptional response subsequent GC exposure. Our data...
This study tested whether dispositional measures of optimism, pessimism, and anxiety affected ambulatory blood pressure (BP) mood any cardiovascular effects dispositions were moderated by mood. Pessimistic anxious adults had higher BP levels felt more negative less positive than did optimists or low throughout the monitoring. The few times that feel associated with as high those observed among pessimists individuals, regardless their To extent trait neuroticism, these findings suggest...
We evaluated whether psychosocial factors that are related to cardiovascular disease and type 2 diabetes predict prospectively the risk for metabolic syndrome using different clinical criteria available defining syndrome.Women were enrolled in a population-based prospective cohort study called Healthy Women Study followed an average of 15 years after baseline. Metabolic was defined via World Health Organization, National Cholesterol Education Program Adult Treatment Panel III, International...
Personality traits are basic dimensions of behavioral variation, and twin, family, adoption studies show that around 30% the between-individual variation is due to genetic variation. There rapidly growing interest in understanding evolutionary basis this Several mechanisms could explain how maintained traits, each these makes predictions terms relative contribution rare common variants personality magnitude nonadditive influences, whether affected by inbreeding. Using genome-wide single...
It has been hypothesized that sleep deprivation may manifest in children as behavioral symptoms rather than tiredness, but only a few studies have investigated this hypothesis. The objective of our study was to evaluate whether short is associated with attention-deficit/hyperactivity disorder 7- 8-year-old children.We performed cross-sectional born 1998 Helsinki, Finland. participants included 280 (146 girls, 134 boys) mean age 8.1 years (SD: 0.3; range: 7.4-8.8). Sleep quality measured by...
Objective: Optimistic people report a higher quality of life, engage in more active coping and adopt health-promoting behaviors than low optimism, ie, pessimism. We evaluated whether pessimists are likely to show progression carotid disease optimists. Methods: A total 209 middle-aged healthy premenopausal women enrolled an epidemiological study cardiovascular risk factors had scans 10.4 years 13.5 later when they were at least 5 postmenopausal. Women completed the Life Orientation Test...
Children with very low birth weight (<1500 g) are at increased risk for attention deficit hyperactivity disorder (ADHD). Whether this continues into adulthood is unknown. The authors assessed behavioral symptoms of ADHD in a well-characterized cohort very-low-birth-weight young adults who were either small gestational age (less than two standard deviations below the Finnish mean) or appropriate (within mean).A total 162 subjects (small age: N=52; N=110) and 172 term comparison 18 to 27 years...