A5022696837- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- RNA modifications and cancer
- Cancer-related gene regulation
- Early Childhood Education and Development
- Hormonal Regulation and Hypertension
- Adolescent and Pediatric Healthcare
- Signaling Pathways in Disease
- Genetics and Neurodevelopmental Disorders
- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Infant Development and Preterm Care
- Metabolomics and Mass Spectrometry Studies
- Anesthesia and Neurotoxicity Research
- Child Abuse and Trauma
- Identity, Memory, and Therapy
- Maternal Mental Health During Pregnancy and Postpartum
- Family Support in Illness
- Child and Adolescent Psychosocial and Emotional Development
- Intergenerational Family Dynamics and Caregiving
- Tryptophan and brain disorders
Max Planck Institute of Psychiatry
2015-2024
James J. Peters VA Medical Center
2020
McLean Hospital
2020
Max Planck Society
2017
Aging and psychosocial stress are associated with increased inflammation disease risk, but the underlying molecular mechanisms unclear. Because both aging also lasting epigenetic changes, a plausible hypothesis is that along lifespan could confer risk through effects on molecules involved in inflammatory processes. Here, by combining large-scale analyses human cohorts experiments cells, we report FKBP5, protein implicated physiology, contributes to these relations. Across independent (total...
Significance Prenatal stress exposure is associated with a wide range of health problems later in life. This may be mediated part via glucocorticoid (GC) during fetal development known to impact neurogenesis and induce epigenetic changes. Using human hippocampal progenitor cell line assess the effects GCs, we observe that GCs early results lasting changes DNA methylation (DNAm). Lasting DNAm alterations are significantly enhanced transcriptional response subsequent GC exposure. Our data...
Objective: There is growing evidence that exposure to trauma prior conception can affect offspring. The authors have reported adult offspring of Holocaust survivors showed lower methylation FK506 binding protein 5 (FKBP5) intron 7, site 6 compared with Jewish comparison volunteers. present study sought replicate this finding in a larger sample and examine parental correlates observed effects. Methods: Cytosine was measured blood using pyrosequencing. independent replication consisted 125 31...
Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting alterations DNA methylation (DNAm) important regulatory genes response. Here, we investigate dynamics GC-dependent changes key regions FKBP5 locus which ELS-associated DNAm have been reported. We repeatedly measured human peripheral blood samples from 2 independent cohorts exposed to GC...
Abstract Individuals who have experienced high levels of childhood stress are at increased risk for a wide range behavioral problems that persist into adulthood, yet the neurobiological and molecular mechanisms underlying these associations remain poorly understood. Many difficulties observed in stress-exposed children involve with learning inhibitory control. This experiment was designed to test individuals' ability learn inhibit responding during laboratory task. To do so, we measured...
Childhood maltreatment is an important risk factor for adult depression and has been associated with changes in the hypothalamic pituitary adrenal (HPA) axis, including cortisol secretion methylation of FKBP5 gene. Furthermore, associations between HPA have reported. This study investigated whole-blood mRNA levels, serum childhood maltreatment, depressive symptoms status (assessed via target bisulfite sequencing) 105 CpGs at locus using data from general population-based Study Health...
Background: Preterm birth associates with a substantially increased risk of later cardiovascular disease and neurodevelopmental disorders. Understanding underlying mechanisms will facilitate the development screening intervention strategies to reduce risk. Changes in DNA methylation have been proposed as one mechanism linking early environment We tested hypothesis that preterm altered genes encoding insulin-like growth factor 2 (IGF2) FK506 binding protein 5 (FKBP5), which appear...
The ability to accurately and efficiently measure DNA methylation is critical advance the understanding of this epigenetic mechanism its contribution common diseases. Here, we present a highly accurate method using bisulfite sequencing (termed HAM-TBS). This novel able assess in multiple samples with high accuracy cost-effective manner. We developed assay for FKBP5 locus, an important gene regulation stress system previously linked stress-related disorders, but applicable any locus interest....
FKBP5 is an important stress-regulatory gene implicated in stress-related psychiatric diseases. Single nucleotide polymorphisms of the were shown to interact with early life stress alter glucocorticoid-related response and moderate disease risk. Demethylation cytosine-phosphate-guanine-dinucleotides (CpGs) regulatory glucocorticoid-responsive elements was suggested be mediating epigenetic mechanism for long-term effects, but studies on Fkbp5 DNA methylation (DNAm) rodents are so far limited....
Abstract Background The ability to accurately and efficiently measure DNA methylation is vital advance the understanding of this mechanism its contribution common diseases. Here, we present a highly accurate method using bisulfite sequencing (termed HAM-TBS). This novel able assess in multiple samples with high accuracy cost-effective manner. We developed assay for FKBP5 locus, an important gene regulation stress system previously linked stress-related disorders, but applicable any locus...
Abstract Aging and psychosocial stress are associated with increased inflammation disease risk, but the underlying molecular mechanisms poorly understood. Because both aging also lasting epigenetic changes, a plausible hypothesis is that exposure along lifespan could confer risk by epigenetically deregulating molecules involved in inflammatory processes. Here, combining large-scale analyses human cohorts mechanistic vitro investigations, we found FKBP5, protein implicated physiology,...