A5064118768- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Risk Factors
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Lipid metabolism and disorders
- Physical Activity and Health
- Cancer, Lipids, and Metabolism
- Heart Rate Variability and Autonomic Control
- Cardiac Health and Mental Health
- Nutrition, Genetics, and Disease
- Cholesterol and Lipid Metabolism
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
Turku University Hospital
2016-2025
University of Turku
2016-2025
RELX Group (United States)
2022
Murdoch Children's Research Institute
2007-2021
Paavo Nurmen Säätiö
1999-2019
Centres for Economic Development, Transport and the Environment
2007-2019
Zora Biosciences (Finland)
2019
Tampere University Hospital
2004-2018
Tampere University
2008-2018
Fimlab (Finland)
2014-2018
<h3>Context</h3> Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life. <h3>Objective</h3> To study relationship between measured common carotid artery intima-media thickness (IMT), a marker preclinical atherosclerosis, adulthood. <h3>Design, Setting, Participants</h3> Population-based, prospective cohort conducted at 5 centers Finland among 2229 white adults aged 24 39 years who were examined ages 3...
Dietary patterns are useful in nutritional epidemiology, providing a comprehensive alternative to the traditional approach based on single nutrients. The Cardiovascular Risk Young Finns Study is prospective cohort study with 21-year follow-up. At baseline, detailed quantitative information subjects' food consumption was obtained using 48 h dietary recall method ( n 1768, aged 3–18 years). interviews were repeated after 6 and 21 years 1200 1037, respectively). We conducted principal component...
Purpose The aim of the study was to investigate tracking physical activity (PA) from preschool age adulthood in six cohorts males and females. Methods A random sample 3596 boys girls 3–18 yr participated Cardiovascular Risks Young Finns Study 1980. follow-up measurements were repeated 1986, 1992, 2001, 2007. PA measured by mother’s report 3- 6-yr-olds self-report 9-yr-olds older. Tracking analyzed using Spearman rank-order correlation a simplex model. Results Mother-reported at 3 6...
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive profiling of circulating metabolites captures highly heritable traits, can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide study genetic influences on 123 traits quantified by nuclear magnetic resonance metabolomics from up 24,925 individuals and identify eight...
In Finland, coronary heart disease (CHD) incidence was very high in the 1960s and 1970s. line with this incidence, Seven Countries Study showed that level of serum cholesterol Finns also highest among investigated countries 1960s. Because several studies indicated atherosclerotic process starts early life, accord World Health Organization Recommendation 1978 which stated assessing atherosclerosis precursors children should be initiated, a program launched Finland late 1970s to study...
A high-throughput proton (1H) nuclear magnetic resonance (NMR) metabonomics approach is introduced to characterise systemic metabolic phenotypes. The methodology combines two molecular windows that contain the majority of information available by 1H NMR from native serum, e.g. serum lipids, lipoprotein subclasses as well various low-molecular-weight metabolites. experimentation robotics-controlled and fully automated with a capacity about 150-180 samples in 24 h. To best our knowledge,...
Branched-chain and aromatic amino acids are associated with the risk for future type 2 diabetes; however, underlying mechanisms remain elusive. We tested whether predict insulin resistance index in healthy young adults.Circulating isoleucine, leucine, valine, phenylalanine, tyrosine, six additional were quantified 1,680 individuals from population-based Cardiovascular Risk Young Finns Study (baseline age 32 ± 5 years; 54% women). Insulin was estimated by homeostasis model assessment (HOMA)...
Endothelial dysfunction may play a pathophysiological role in the development of atherosclerosis subjects with type 1 diabetes. We examined whether alterations vascular endothelial function exist children diabetes and tested hypothesis that is associated early structural atherosclerotic changes these children.Noninvasive ultrasound was used to measure brachial artery flow-mediated dilation (FMD) responses carotid intima-media thickness (IMT) 75 (mean age 11+/-2 years), 45 (diabetes duration...
Endothelial vasodilator dysfunction and carotid intima-media thickening (IMT) are 2 indicators of subclinical cardiovascular disease. We examined their correlation interaction with risk factors in a large, community-based cohort young adults.As part the longitudinal Cardiovascular Risk Young Finns Study, we measured endothelium-dependent brachial artery flow-mediated dilatation (FMD) IMT by ultrasound 2109 healthy adults aged 24 to 39 years. FMD was inversely associated (P< or =0.001)...
Childhood cardiovascular risk factors predict subclinical adult disease, but links to clinical events are unclear. In a prospective cohort study involving participants in the International Cardiovascular Cohort (i3C) Consortium, we evaluated whether childhood (at ages of 3 19 years) were associated with adulthood after mean follow-up 35 years. Body-mass index, systolic blood pressure, total cholesterol level, triglyceride and youth smoking analyzed use i3C-derived age- sex-specific z scores...
Background— Exposure to risk factors in childhood may have long-term influences on vascular function. We examined the relationship between identified and arterial elasticity assessed adulthood. Methods Results— Carotid artery compliance (CAC), Young’s elastic modulus (YEM), stiffness index (SI), 3 measures of large-artery elasticity, were with noninvasive ultrasound 2255 healthy white adults aged 24 39 years participating a population-based cohort study who had factor data available since...
Background— Atherosclerosis has its roots in childhood. Therefore, defining the age when childhood risk exposure begins to relate adult atherosclerosis may have implications for pediatric cardiovascular disease prevention and provide insights about early determinants of development. The aim this study was investigate influence on associations between factors carotid artery intima-media thickness, a marker subclinical atherosclerosis. Methods Results— We used data 4380 members 4 prospective...
Metabolite associations with insulin resistance were studied in 7,098 young Finns (age 31 ± 3 years; 52% women) to elucidate underlying metabolic pathways. Insulin was assessed by the homeostasis model (HOMA-IR) and circulating metabolites quantified high-throughput nuclear magnetic resonance spectroscopy two population-based cohorts. Associations analyzed using regression models adjusted for age, waist, standard lipids. Branched-chain aromatic amino acids, gluconeogenesis intermediates,...
Background Increased adiposity is linked with higher risk for cardiometabolic diseases. We aimed to determine what extent elevated body mass index (BMI) within the normal weight range has causal effects on detailed systemic metabolite profile in early adulthood. Methods and Findings used Mendelian randomization estimate of BMI 82 metabolic measures 12,664 adolescents young adults from four population-based cohorts Finland (mean age 26 y, 16–39 y; 51% women; mean ± standard deviation 24±4...