A5064686060- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Children's Physical and Motor Development
- Genetic Associations and Epidemiology
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- Health and Lifestyle Studies
- Liver Disease Diagnosis and Treatment
- Physical Activity and Health
- Hormonal and reproductive studies
- Eating Disorders and Behaviors
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Adipokines, Inflammation, and Metabolic Diseases
- Gestational Diabetes Research and Management
- Body Composition Measurement Techniques
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
- Cardiovascular Disease and Adiposity
- Lipid metabolism and biosynthesis
- Pregnancy and preeclampsia studies
University of Eastern Finland
2012-2021
University of Jyväskylä
2018
Fazer (Finland)
2017
Institute for Biomedicine
2014-2016
Finland University
2016
University of Split
2016
Kuopio University Hospital
2002-2003
High levels of cytokines are risk factors for type 2 diabetes. Therefore, we investigated whether the promoter polymorphisms tumor necrosis factor-alpha (TNF-alpha; G-308A) and interleukin 6 (IL-6; C-174G) genes predict conversion from impaired glucose tolerance (IGT) to diabetes in Finnish Diabetes Prevention Study. Altogether, 490 overweight subjects with IGT whose DNA was available were randomly divided into one two treatment assignments: control group intensive, individualized diet...
Type 2 diabetes is known to be associated with a small body size at birth. Body birth an indicator of the intrauterine environment. There also well-established association between peroxisome proliferator-activated receptor (PPAR)-γ2 gene and type diabetes. We therefore assessed whether effects Pro12Ala polymorphism PPAR-γ2 on insulin sensitivity concentrations in adult life are modified by found that Pro12Pro polymorphisms elderly people depended their The well-known resistance was seen only...
The association of the Pro12Ala polymorphism PPAR-γ2 gene with incidence type 2 diabetes was investigated in 522 subjects impaired glucose tolerance (IGT) participating Finnish Diabetes Prevention Study. Subjects were randomized to either an intensive diet and exercise group or a control group. By 3 years intervention, odds ratio development for Ala12 allele 2.11-fold compared that Pro12Pro genotype (95% CI 1.20–3.72). risk increased also who gained weight belonged In intervention group,...
Lifestyle interventions reduce the incidence of type 2 diabetes among individuals with impaired glucose tolerance (IGT). However, it is unknown whether this due to improved insulin sensitivity or secretion. We investigated at baseline and secretion applying frequently sampled intravenous test (FSIGT) in 87 101 obese middle-aged subjects IGT randomized into an intervention a control group Finnish Diabetes Prevention Study. FSIGT was repeated after 4 years 52 people. There were no significant...
Lower levels of physical activity (PA) and sedentary behaviour (SB) have been associated with increased cardiometabolic risk among children. However, little is known about the independent combined associations PA SB as well different types these behaviours in We therefore investigated relationships children.The subjects were a population sample 468 children 6-8 years age. assessed by questionnaire administered parents validated monitor combining heart rate accelerometry measurements. body...
Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common that influence fetal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We seven independent top single nucleotide polymorphisms (SNPs) (P < 1 × 10−6) birth length, which three were novel and four or near loci to be associated with height (LCORL, PTCH1, GPR126 HMGA2). The SNPs followed-up nine replication...
We investigated the associations of cardiovascular and motor performance in grade 1 with academic skills grades 1-3.The participants were 6- to 8-yr-old children complete data 1-2 for 174 3 167 children. Maximal workload during exercise test was used as a measure performance. The shuttle run (SRT) time, errors balance test, number cubes moved box block (BBT) measures Academic assessed using reading fluency, comprehension, arithmetic skill tests.Among boys, longer SRT time associated poorer...
Summary Objective and methods We compared I n B ody 720 segmental multifrequency bioimpedance analysis ( SMF ‐ BIA ) with L unar P rodigy A dvance dual‐energy X ‐ray absorptiometry DXA in assessment of body composition among 178 predominantly prepubertal children. Segmental agreement compartments was carried out, inter‐relationships anthropometric other measures were defined. Moreover, the relations different reference criteria for excess fat evaluated. Results The prevalence varies greatly...
The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for in influencing food intake. We conducted combined analysis of 16,094 boys girls aged 1–18 years from 14 studies to examine following: 1) association between rs9939609 variant (or proxy) total energy macronutrient intake; 2) interaction dietary intake, BMI. found that BMI-increasing allele (minor allele) was associated increased intake (effect per = 14.3 kcal/day [95% CI...
Background There are no prospective studies that would have compared the relationships of different types physical activity (PA) and sedentary behavior (SB) with academic skills among children. We therefore investigated associations PA SB reading arithmetic in a follow-up study Methods The participants were 186 children (107 boys, 79 girls, 6–8 yr) who followed-up Grades 1–3. assessed using questionnaire Grade 1. Reading fluency, comprehension standardized tests at end Results Among all more...
Associations of cardiorespiratory fitness (CRF), physical activity (PA), sedentary behavior, and body fat percentage (BF%) with arterial stiffness dilation capacity were investigated in 160 prepubertal children (83 girls) 6-8 years age. We assessed CRF (watts/lean mass) by maximal cycle ergometer exercise test, total PA, structured exercise, unstructured commuting to from school, recess PA screen-based behavior questionnaire, BF% using dual-energy X-ray absorptiometry, pulse contour...
We studied differences in physical activity (PA), sedentary behaviour (SB), and the types of PA SB between Finnish girls boys children from different socioeconomic backgrounds (SES). assessed PA, SB, parental education, household income using detailed questionnaires a representative population sample 486 (238 girls, 248 boys) aged 6-8 years. Girls spent on average 1.7 h/day 2.0 total (p = 0.002). Altogether 66% 54% had less than 2 h per day 0.012). lower levels unsupervised (45 vs. 54...
Adrenarche refers to the onset of increased production adrenal androgens in childhood leading variably clinical signs androgen action. The prevalence and presentation adrenarche prepubertal girls boys is not well known.Our objective was examine a population sample children aged less than 9 years.This cross-sectional study included (209 228 boys; median age 7.6 [range 6.8-8.9] years) taking part Physical Activity Nutrition Children (PANIC) Study.The assessed.The any sign action higher (26.1%...
Evidence on the associations of dietary patterns with cognition in children is limited. Therefore, we investigated Baltic Sea Diet Score (BSDS) and Dietary Approaches to Stop Hypertension (DASH) score children. The present cross-sectional study sample included 428 aged 6–8 years (216 boys 212 girls). BSDS DASH were calculated using data from 4 d food records, higher scores indicating better diet quality. Cognition was assessed by Raven's Coloured Progressive Matrices (CPM) score, a...
Abstract We studied vitamin D intake, serum 25-hydroxyvitamin (S-25(OH)D) concentration, determinants of S-25(OH)D and risk factors for <50 nmol/l in a population sample Finnish children. 184 girls 190 boys aged 6–8 years, analysed by chemiluminescence immunoassay assessed diet quality using 4-d food records other lifestyle questionnaires. the linear regression logistic regression. Mean dietary intake was 5·9 ( sd 2·1) µg/d. Altogether, 40·8 % children used no supplements. Of all...