A5100453648- Genetic Associations and Epidemiology
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Gut microbiota and health
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Genetic Mapping and Diversity in Plants and Animals
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Genomic variations and chromosomal abnormalities
- COVID-19 Clinical Research Studies
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Congenital heart defects research
- HIV-related health complications and treatments
- Genomics and Rare Diseases
- HER2/EGFR in Cancer Research
- SARS-CoV-2 and COVID-19 Research
- Genetic and phenotypic traits in livestock
- Circular RNAs in diseases
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- BRCA gene mutations in cancer
- Cardiovascular Health and Risk Factors
- Congenital Heart Disease Studies
Albert Einstein College of Medicine
2016-2025
307th Hospital of Chinese People’s Liberation Army
2023
Montefiore Medical Center
2010-2022
Chinese PLA General Hospital
2021-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Academy of Medical Sciences
2022
Peking University First Hospital
2022
Peking University
2022
Cancer Hospital of Chinese Academy of Medical Sciences
2022
Peking University Cancer Hospital
2022
Abstract Background Since December 2019, acute respiratory disease (ARD) due to 2019 novel coronavirus (2019-nCoV) emerged in Wuhan city and rapidly spread throughout China. We sought delineate the clinical characteristics of these cases. Methods extracted data on 1,099 patients with laboratory-confirmed 2019-nCoV ARD from 552 hospitals 31 provinces/provincial municipalities through January 29 th , 2020. Results The median age was 47.0 years, 41.90% were females. Only 1.18% had a direct...
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, genetic populations Hispanic/Latino African ancestry are limited. In addition, these more complex linkage disequilibrium structure. order better define the architecture understudied populations, we leveraged >100,000 phased sequences available from deep-coverage whole genome sequencing through multi-ethnic NHLBI Trans-Omics for Precision Medicine (TOPMed) program impute...
Background: Patients with obesity are at increased risk of exacerbations from viral respiratory infections. However, the association severity corona virus disease 2019 (COVID-19) is unclear. We hereby examined this using data only referral hospital in Shenzhen, China.Methods: 383 COVID-19 patients admitted 11 January to 16 February 2020 Third People's Hospital China were included. Underweight was defined by body mass index (BMI) lower than 18·5 kg/m2, normal weight 18·5-23·9 kg/m2 ,...
Abstract Background Since late December, 2019, an outbreak of pneumonia cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and continued to spread throughout China across globe. To date, few data on immunologic features Coronavirus Disease 2019 (COVID-19) have been reported. Methods In this single-centre retrospective study, a total 21 patients with who were laboratory-confirmed be infected SARS-CoV-2 Wuhan Tongji hospital included from Dec 19,...
Accumulation of mutations in somatic cells has been implicated as a cause aging since the 1950s. However, attempts to establish causal relationship between and have constrained by lack methods directly identify mutational events primary human tissues. Here we provide genome-wide mutation frequencies spectra B lymphocytes from healthy individuals across entire lifespan using highly accurate single-cell whole-genome sequencing method. We found that number increases <500 per cell newborns...
Alzheimer’s disease (AD) is the most common type of dementia, and promptly diagnosis AD crucial for delaying development improving patient quality life. However, detection, particularly in early stages, remains a substantial challenge due to lack specific biomarkers. The present study was undertaken identify validate potential circulating miRNAs as novel biomarkers AD. Solexa sequencing employed screen expression profile serum controls. RT-qPCR used confirm altered at individual level....
Breast cancer is considered to result from a combination of genetic and lifestyle-related factors, but the degree which an overall healthy lifestyle may attenuate impact multiple variants on invasive breast risk remains equivocal.Using Cox proportional hazards regression models, we examined association modified index (HLI) with by group among 146 326 women UK Biobank. We generated HLI score based diet, physical activity, smoking, alcohol consumption anthropometry, polygenic (PRS) using 304...
Abstract Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol 207 diseases in 12-year China Kadoorie Biobank >512,000 adults (41% men), including 168,050 genotyped ALDH2 - rs671 and ADH1B rs1229984 , >1.1 ICD-10 coded hospitalized events. At baseline, 33% men drank regularly. Among men, intake was positively associated 61 diseases, 33 not defined by World...
Prospective studies are needed to examine the temporal relationship between oral human papillomavirus (HPV) detection and risk of head neck squamous cell carcinoma (HNSCC). Moreover, cavity contains a wide spectrum α-, β-, γ-HPV types, but their association with HNSCC is unknown.To prospectively associations in incident HNSCC.A nested case-control study was carried out among 96 650 participants, cancer free at baseline, available mouthwash samples 2 prospective cohort studies: (1) American...
Abstract Background Hispanics living in the USA may have unrecognized potential birthplace and lifestyle influences on gut microbiome. We report a cross-sectional analysis of 1674 participants from four centers Hispanic Community Health Study/Study Latinos (HCHS/SOL), aged 18 to 74 years old at recruitment. Results Amplicon sequencing 16S rRNA gene V4 fungal ITS1 fragments self-collected stool samples indicate that host microbiome is determined by sociodemographic migration-related...
BackgroundGut microbiota alteration has been implicated in HIV infection and metabolic disorders. The relationship between gut diabetes rarely studied HIV-infected individuals, who have excess risk of disorders.MethodsOur study during 2015–2016 enrolled predominantly African Americans Hispanics the Women's Interagency Study. We 28 women with long-standing under antiretroviral therapy 20 HIV-uninfected, but at high infection, (16 HIV+ 6 HIV- diabetes). Fecal samples were analyzed by...
Background Human Papillomavirus type 16 (HPV16) causes over half of all cervical cancer and some HPV16 variants are more oncogenic than others. The genetic basis for the extraordinary properties compared to other HPVs is unknown. In addition, we neither know which nucleotides vary across within HPV types lineages, nor single nucleotide polymorphisms (SNPs) determine oncogenicity. Methods A reference set 62 complete genome sequences was established used examine patterns evolutionary...
The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for in influencing food intake. We conducted combined analysis of 16,094 boys girls aged 1–18 years from 14 studies to examine following: 1) association between rs9939609 variant (or proxy) total energy macronutrient intake; 2) interaction dietary intake, BMI. found that BMI-increasing allele (minor allele) was associated increased intake (effect per = 14.3 kcal/day [95% CI...
Few genome-wide association studies (GWAS) of type 2 diabetes (T2D) have been conducted in U.S. Hispanics/Latinos diverse backgrounds who are disproportionately affected by diabetes. We a GWAS 2,499 T2D case subjects and 5,247 control from six Hispanic/Latino background groups the Hispanic Community Health Study/Study Latinos (HCHS/SOL). Our identified two known loci (
The follow-up rate, a standard index of the completeness follow-up, is important for assessing validity cohort study. A common method estimating "Percentage Method", defined as fraction all enrollees who developed event interest or had complete can severely underestimate degree follow-up. Alternatively, median time does not indicate and reverse Kaplan-Meier based Clark's Completeness Index (CCI) also have limitations. We propose new definition Person-Time Follow-up Rate (PTFR), which...
It is unknown whether disrupted tryptophan catabolism associated with cardiovascular disease (CVD) in human immunodeficiency virus (HIV)–infected individuals. Plasma and kynurenic acid were measured 737 women men (520 HIV+, 217 HIV−) from the Women's Interagency HIV Study Multicenter AIDS Cohort Study. Repeated B-mode carotid artery ultrasound imaging was obtained 2004 through 2013. We examined associations of baseline tryptophan, acid, acid-to-tryptophan (KYNA/TRP) ratio, risk plaque. After...
Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as a treatment for 2019 (COVID-19). We compared the mortality and clinical outcome of patients COVID-19 who received 200 mL CCP spike protein IgG titer ≥ 1:2430 (median 1:47,385) within 72 hours admission propensity score-matched controls cared at medical center in Bronx, between April 13 May 4, 2020. Matching criteria were age, sex, body mass index, race, ethnicity,...
Drug-induced liver injury (DILI) has been a public, economic and pharmaceutical issue for many years. Enormous effort made discovering developing novel biomarkers diagnosing monitoring both clinical preclinical DILI at an early stage, though progress relatively slow. Additionally, herb-induced is emerging cause of disease because herbal medicines are increasingly being used worldwide. Recently, circulating microRNAs (miRNAs) have shown potential to serve as novel, minimally invasive diagnose...
Stochastic processes and imprinting, along with genetic factors, lead to monoallelic or allele-biased gene expression. expression fine-tunes information processing in immune cells the olfactory system, imprinting plays an important role development. Recent studies suggest that both stochastic events may be more widespread than previously considered. We are interested occurring brain because parent-of-origin effects suggestive of appear play a transmission schizophrenia (SZ) autism spectrum...