A5059574252- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Advanced Chemical Sensor Technologies
- Diet and metabolism studies
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Analytical Chemistry and Chromatography
- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Colorectal Cancer Treatments and Studies
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- HIV-related health complications and treatments
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Pregnancy and preeclampsia studies
- Chronic Kidney Disease and Diabetes
- Eicosanoids and Hypertension Pharmacology
- Mass Spectrometry Techniques and Applications
- Alcohol Consumption and Health Effects
Albert Einstein College of Medicine
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
Peking Union Medical College Hospital
2024-2025
Zhejiang University
2014-2025
Taian City Central Hospital
2018-2025
Qingdao University
2025
Hunan University
2025
Nanjing University of Chinese Medicine
2023-2024
The Bronx Defenders
2024
Nanjing Medical University
2023
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated disease etiology, affect drug metabolism, toxicity, efficacy. However, molecular basis these microbe-host interactions roles bacterial species are obscure. We now demonstrate a"transgenomic" approach to link metabolic phenotype (metabotype) variation. used combination spectroscopic, microbiomic, multivariate...
Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis small-molecule metabolite production. We have performed a serum metabolic analysis to test hypothesis that distinct profiles malignant tumors are reflected in biofluids. In this study, we analyzed metabolites from 64 colorectal cancer (CRC) patients 65 healthy controls using gas chromatography...
As the lipidomics field continues to advance, self-evaluation within community is critical. Here, we performed an interlaboratory comparison exercise for using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The study comprised 31 diverse laboratories, with each laboratory different workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates associated uncertainties...
Hepatocellular carcinoma (HCC) is a common malignancy in the world with high morbidity and mortality rate. Identification of novel biomarkers HCC remains impeded primarily because heterogeneity disease clinical presentations as well pathophysiological variations derived from underlying conditions such cirrhosis steatohepatitis. The aim this study to search for potential metabolite human using serum urine metabolomics approach. Sera samples were collected patients (n = 82), benign liver tumor...
Schizophrenia is a severe mental disorder that affects 0.5–1% of the population worldwide. Current diagnostic methods are based on psychiatric interviews, which subjective in nature. The lack disease biomarkers to support objective laboratory tests has been long-standing bottleneck clinical diagnosis and evaluation schizophrenia. Here we report global metabolic profiling study involving 112 schizophrenic patients 110 healthy subjects, who were divided into training set test set, designed...
Oral cancer, one of the six most common human cancers with an overall 5-year survival rate <50%, is often not diagnosed until it has reached advanced stage. The aim current study to explore salivary metabolomics as a disease diagnostic and stratification tool for oral cancer leukoplakia evaluate potential metabolome detection squamous cell carcinoma (OSCC). Saliva metabolite profiling group 37 OSCC patients, 32 (OLK) patients 34 healthy subjects was performed using ultraperformance liquid...
After our serum metabonomic study of colorectal cancer (CRC) patients recently published in J. Proteome Res., we profiled urine metabolites from the same group CRC (before and after surgical operation) 63 age-matched healthy volunteers using gas chromatography−mass spectrometry (GC−MS) conjunction with a multivariate statistics technique. A parallel on 1,2-dimethylhydrazine (DMH)-treated Sprague−Dawley rat model was also performed to identify significantly altered associated chemically...
A full spectrum of metabolic aberrations that are directly linked to colorectal cancer (CRC) at early curable stages is critical for developing and deploying molecular diagnostic therapeutic approaches will significantly improve patient survival. We have recently reported a urinary metabonomic profiling study on CRC subjects (n = 60) health controls 63), in which panel metabolite markers was identified. Here, we report second larger cohort 101) healthy 103), using gas chromatography...
Recent studies suggest that biofluid-based metabonomics may identify metabolite markers promising for colorectal cancer (CRC) diagnosis. We report here a follow-up replication study, after previous CRC aiming to distinct serum metabolic signature of with diagnostic potential. Serum metabolites from newly diagnosed patients (N = 101) and healthy subjects 102) were profiled using gas chromatography time-of-flight mass spectrometry (GC-TOFMS) ultraperformance liquid quadrupole (UPLC-QTOFMS)....
Our understanding of the bile acid metabolism is limited by fact that previous analyses have primarily focused on a selected few circulating acids; profiles liver and gastrointestinal tract pools are rarely investigated. Here, we determined how chronic ethanol consumption altered acids in multiple body compartments (liver, tract, serum) rats. Rats were fed modified Lieber-DeCarli liquid diet with 38% calories as (the amount equivalent 4–5 drinks humans). While conjugated predominated...
Chronic stress is closely linked to clinical depression, which could be assessed by a chronic unpredictable mild (CUMS) animal model. We present here GC/MS‐based metabolic profiling approach investigate neurochemical changes in the cerebral cortex, hippocampus, thalamus, and remaining brain tissues. Multi‐criteria assessment for multivariate statistics identify differential metabolites between CUMS‐model rats versus healthy controls. This study demonstrates that significantly perturbed...
Abstract Purpose: Metabolic phenotyping has provided important biomarker findings, which, unfortunately, are rarely replicated across different sample sets due to the variations from analytical and clinical protocols used in studies. To date, very few metabolic hallmarks a given cancer type have been confirmed validated by use of metabolomic approach other modalities. Here, we report metabolomics study identify potential metabolite biomarkers colorectal with theranostic value. Experimental...
Background: Integrated microbiome and metabolomics analyses hold the potential to reveal interactions between host microbiota in relation disease risks. However, there are few studies evaluating how field methods influence fecal characterization profiling. Methods: Five collection (immediate freezing at -20ºC without preservative, OMNIgene GUT, 95% ethanol, RNAlater, Flinders Technology Associates (FTA) cards) were used collect 40 samples from eight healthy volunteers. We performed gut 16S...
Despite recent advances in understanding the pathophysiology of schizophrenia and mechanisms antipsychotic drug action, development biomarkers for diagnosis therapeutic monitoring remains challenging. Metabolomics provides a powerful approach to discover diagnostic by analyzing global changes an individual's metabolic profile response pathophysiological stimuli or intervention. In this study, we performed gas chromatography-mass spectrometry based metabolomic profiling serum unmedicated...
Significance Acute myeloid leukemia (AML) consists of a group hematopoietic malignancies with considerable diversities in clinical and biological features. Recently, not only genetic abnormalities but also “oncometabolites,” such as 2-hydroxyglutarate (2-HG), have been found to play role driving AML pathogenesis serve potential disease markers. In this study on large cohort AML, we that the serum 2-HG level was increased 62 367 (17%) cases distinct hematologic Survival analysis performed 234...
Gastric cardia cancer (GCC), which occurs at the gastric-esophageal boundary, is one of most malignant tumors. Despite its high mortality and morbidity, molecular mechanism initiation progression this disease largely unknown. In study, using proteomics metabolomics approaches, we found that level several enzymes their related metabolic intermediates involved in glucose metabolism were deregulated GCC. Among these enzymes, two subunits controlling pyruvic acid efflux, lactate dehydrogenase A...
Chronic ethanol consumption is associated with not only the alteration of metabolic profiles in biofluids but also composition gut microbiome. Our understanding importance intestinal microbiota as well disturbances elicited by intervention limited fact that previous analyses have primarily focused on and liver tissue metabolome; gastrointestinal (GI) contents are rarely investigated. In this study, we applied a metabonomics approach using high performance liquid chromatography-time-of-flight...
The incidence of precocious puberty (PP, the appearance signs pubertal development at an abnormally early age), is rapidly rising, concurrent with changes diet, lifestyles, and social environment. current diagnostic methods are based on a hormone (gonadotropin-releasing hormone) stimulation test, which costly, time-consuming, uncomfortable for patients. lack molecular biomarkers to support simple laboratory tests, such as blood or urine has been long standing bottleneck in clinical diagnosis...
Although substantial evidence exists that sperm ATP production via glycolysis is required for mammalian function and male fertility, conflicting reports involving multiple species have appeared regarding the ability of individual glycolytic or mitochondrial substrates to support physiological changes occur during capacitation. Several mouse models with defects in signaling pathways capacitation exhibit reductions levels, suggesting regulatory interactions between metabolism signal...
Breast cancer accounts for the largest number of newly diagnosed cases in female patients. Although mammography is a powerful screening tool, about 20% breast cannot be detected by this method. New diagnostic biomarkers are necessary. Here, we used mass spectrometry-based quantitative metabolomics method to analyze plasma samples from 55 patients and 25 healthy controls. A 30 20 age-matched controls were as training dataset establish model identify potential biomarkers. The remaining...
Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the intervertebral disc are predominantly glycolytic due to robust HIF-1 activity. It is generally thought that NP contain few functional mitochondria compared with rely on oxidative metabolism. Consequently, contribution cell metabolism role hypoxia mitochondrial homeostasis poorly understood. Using mitoQC reporter mice, we show for first time our knowledge undergo age-dependent mitophagy vivo....