A5101484596- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Cancer, Lipids, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cutaneous lymphoproliferative disorders research
- Peroxisome Proliferator-Activated Receptors
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Eosinophilic Disorders and Syndromes
- T-cell and Retrovirus Studies
- Pelvic floor disorders treatments
- Aquaculture disease management and microbiota
- Histone Deacetylase Inhibitors Research
- Animal Genetics and Reproduction
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Virus-based gene therapy research
- Neurological Disease Mechanisms and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
China Medical University
2016-2025
First Hospital of China Medical University
2016-2025
Nanjing University of Chinese Medicine
2018-2024
Shandong University
2024
Shandong Provincial Hospital
2024
Hunan Normal University
2023
Lanzhou Jiaotong University
2023
Fourth Hospital of Hebei Medical University
2020-2022
Hebei Medical University
2020-2022
First Affiliated Hospital of Wenzhou Medical University
2017
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing copy number alteration analysis. Recurrent gene mutations fusions tested in an additional 87 93 patients. Among the 29 newly identified in-frame fusions, those involving MEF2D ZNF384 clinically relevant demonstrated to perturb differentiation, EP300-ZNF384 inducing mice. Eight expression subgroups associated characteristic genetic...
Significance Acute myeloid leukemia (AML) consists of a group hematopoietic malignancies with considerable diversities in clinical and biological features. Recently, not only genetic abnormalities but also “oncometabolites,” such as 2-hydroxyglutarate (2-HG), have been found to play role driving AML pathogenesis serve potential disease markers. In this study on large cohort AML, we that the serum 2-HG level was increased 62 367 (17%) cases distinct hematologic Survival analysis performed 234...
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of progenitors, known to be a heterogeneous disease in pediatric and adult patients. Here we attempted better understand the at molecular level based on transcriptomic landscape 707 T-ALL patients (510 pediatric, 190 patients, 7 with unknown age; 599 from published cohorts 108 newly investigated). Leveraging information gene expression enabled us identify 10 subtypes (G1–G10), including previously...
Abstract Acute myeloid leukemia (AML) with retinoic acid receptor γ (RARG) rearrangement has clinical, morphologic, and immunophenotypic features similar to classic acute promyelocytic leukemia. However, AML RARG is insensitive alltrans (ATRA) arsenic trioxide (ATO) carries a poor prognosis. We initiated global cooperative study define the clinicopathological features, genomic transcriptomic landscape, outcomes of rearrangements collected from 29 groups/institutions worldwide. Thirty-four...
DNMT3A mutations are frequently discovered in acute myeloid leukemia (AML), associated with poor outcome. Recently, a relapse case report of AML extramedullary disease has showed that cells harboring variation were detected the cerebral spinal fluid. However, whether causal relationship exists between mutation (D3Amut) and infiltration (EMI) is unclear.We took advantage (R882C) mutation-carrying cell strain, is, OCI-AML3, assessing its migration ability vitro vivo. By RNA interfering...
Vanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be unique paraneoplastic of Hodgkin’s lymphoma with an unfavorable prognosis. We report 34-year-old woman acute jaundice lymphadenopathy, was subsequently confirmed to concurrent vanishing based on liver biopsy. The patient agreed combination chemotherapy brentuximab vedotin achieved complete response. Liver function recovered within 4 months. This article reviews...
Summary Chimeric antigen receptor T (CAR‐T) cell therapy is highly effective in inducing complete remission haematological malignancies. Severe cytokine release syndrome (CRS) the most significant and life‐threatening adverse effect of this therapy. This multi‐centre study was conducted at six hospitals China. The training cohort included 87 patients with multiple myeloma (MM), an external validation 59 MM another 68 acute lymphoblastic leukaemia (ALL) or non‐Hodgkin lymphoma (NHL). levels...
DNA methyltransferase 3A (DNMT3A) catalyzes de novo methylation and plays important roles in the pathogenesis of acute myeloid leukemia. However, expression status DNMT3A variants leukemia remains obscure. This study aimed to assess levels alternative splicing explore their (AML). gene were assessed, measuring effects on cell proliferation. In addition, evaluated patients. Four identified, with DNMT3A1 DNMT3A2V found be dominant lines. Moreover, overexpression delayed proliferation; while,...
Background: To explore the value of transvaginal real-time shear wave elastography (SWE) in diagnosis endometrial lesions. Methods: A total 140 female patients with lesions, confirmed by pathological results, were divided into three groups: 45 cases polyps, 29 hyperplasia and 66 cancer. 100 normal endometrium used as control group, including 52 proliferative stage 48 secretory stage. Transvaginal was performed all four groups. Results: Emean, Emax Esd expressed average standard deviation....
6510 Background: Patients diagnosed with higher-risk myelodysplastic syndrome (MDS) have poor prognosis. Azacitidine (Aza) has been shown to prolong survival in patients treatment-naive, MDS compared a menu of standard care options. IMM01 is fusion protein comprising recombinant signal regulatory α (SIRPα) and IgG1, exerting anti-tumor effects by inhibiting the "Don't eat me" activating "Eat signal, leading robust antibody-dependent cellular phagocytosis (ADCP). Methods: This an open-label,...