Yongjin Li
A5101561342- Functional Equations Stability Results
- Optimization and Variational Analysis
- Fixed Point Theorems Analysis
- Nonlinear Differential Equations Analysis
- Advanced Banach Space Theory
- Acute Lymphoblastic Leukemia research
- Fractional Differential Equations Solutions
- Mathematical and Theoretical Epidemiology and Ecology Models
- Mathematical Inequalities and Applications
- Chronic Myeloid Leukemia Treatments
- Approximation Theory and Sequence Spaces
- Numerical methods for differential equations
- COVID-19 epidemiological studies
- Advanced Topics in Algebra
- Mathematics and Applications
- Acute Myeloid Leukemia Research
- Differential Equations and Numerical Methods
- Bioinformatics and Genomic Networks
- Nonlinear Waves and Solitons
- Childhood Cancer Survivors' Quality of Life
- Machine Learning in Bioinformatics
- Multi-Criteria Decision Making
- Spine and Intervertebral Disc Pathology
- Gene expression and cancer classification
- Holomorphic and Operator Theory
Sun Yat-sen University
2016-2025
Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital
2024
Guangzhou University of Chinese Medicine
2018-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2021-2024
Fujian Jiangxia University
2024
Guangzhou Education Bureau
2024
Systems Engineering Society of China
2023
Capital Medical University
2022-2023
National Clinical Research Center for Digestive Diseases
2023
St. Jude Children's Research Hospital
2013-2022
Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, alterations lymphoid transcription factor genes, and poor outcome. The frequency spectrum genetic in Ph-like ALL its responsiveness tyrosine kinase inhibition are undefined, especially adolescents adults.
Abstract Motivation: Mining the hereditary disease-genes from human genome is one of most important tasks in bioinformatics research. A variety sequence features and functional similarities between known those not to be involved disease have been systematically examined efficient classifiers constructed based on identified common patterns. The availability genome-wide protein–protein interactions (PPIs) provides us with new opportunity for discovering by topological PPIs network. Results:...
Purpose Philadelphia chromosome (Ph) –like acute lymphoblastic leukemia (ALL) is a high-risk subtype of childhood ALL characterized by kinase-activating alterations that are amenable to treatment with tyrosine kinase inhibitors. We sought define the prevalence and genomic landscape Ph-like in adults assess response conventional chemotherapy. Patients Methods The frequency was assessed gene expression profiling 798 patients B-cell age 21 86 years. Event-free survival overall were determined...
Clinical diseases are characterized by distinct phenotypes. To identify disease genes is to elucidate the gene-phenotype relationships. Mutations in functionally related may result similar It reasonable predict disease-causing integrating phenotypic data and genomic data. Some genetic genetically or phenotypically similar. They share common pathogenetic mechanisms. Identifying relationship between will facilitate better understanding of mechanism diseases.In this article, we constructed a...
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing copy number alteration analysis. Recurrent gene mutations fusions tested in an additional 87 93 patients. Among the 29 newly identified in-frame fusions, those involving MEF2D ZNF384 clinically relevant demonstrated to perturb differentiation, EP300-ZNF384 inducing mice. Eight expression subgroups associated characteristic genetic...
Abstract Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify between MEF2D (myocyte enhancer factor 2D) and five genes ( BCL9 , CSF1R DAZAP1 HNRNPUL1 SS18 ) 22 B progenitor (B-ALL) cases with a distinct gene expression profile, the most common which is MEF2D-BCL9 . Examination an extended cohort 1,164 B-ALL identified 30 rearrangements, include additional fusion partner, FOXJ2 ; thus, MEF2D-...
BCR-ABL1–like acute lymphoblastic leukemia (ALL) is a recently identified B-cell ALL (B-ALL)subtype with poor outcome that exhibits gene expression profile similar to BCR-ABL1-positive but lacks the BCR-ABL1 fusion protein. We examined of children treated risk-directed therapy based on minimal residual disease (MRD) levels during remission induction.Among 422 patients B-ALL enrolled onto Total Therapy XV study between 2000 and 2007, 344 had adequate samples for profiling. Next-generation...
The scaling exponent of a hierarchy cities used to be regarded as fractional. This paper investigates newly constructed system equation for Hepatitis B disease in sense Atanganaa–Baleanu Caputo (ABC) fractional order derivative. proposed approach has five distinctive quantities, namely, susceptible, acute infections, chronic infection, immunized and vaccinated populace. By applying some well-known results fixed point theory, we find the Ulam–Hyers type stability qualitative analysis...
In this research article, the authors intend to develop and analyze an epidemic model that describes progression of acute chronic HBV in a population. The threshold number R0 was obtained using well-known next-generation matrix approach. stability disease-free disease present states proposed is investigated basic reproduction number. Results found during dynamical analysis show exhibits backward bifurcation. To control spread infection; vaccination treatment were introduced as variables...
In the literature, many researchers have studied Lotka‐Volterra (L‐V) models for different types of studies. order to continue study, we consider a fractional‐order L‐V model involving three species in Atangana‐Baleanu‐Caputo (ABC) sense fractional derivative. This new has potentials large number research‐oriented The first point that arises is whether solution or not. Therefore, answer this question, existence and uniqueness (EU) solutions then Hyers‐Ulam (HU) stability proposed model.
Abstract In this paper, a stochastic model (with random noise transmission) is designed. The possesses substantial potential to describe the dynamical behavior of Hepatitis B (HBV) virus and it’s control by applying strategy vaccinating an offspring. number basic reproductive calculated proved that system holds some sharp threshold properties. It investigated has bounded, unique positive solution subject initial data. Furthermore, stability been presented using Lyapunov functional theory....
Pediatric acute lymphoblastic leukemia elicits a broad, functional, antitumor T cell response, targeting multiple mutations.
This paper deals with the existence of solution for an impulsive Riemann–Liouville fractional neutral functional stochastic differential equation infinite delay order $1<\beta<2$ and its Hyers–Ulam stability. We prove mild solutions using basic theorems equation. The result is obtained by Mönch's fixed point theorem. Finally, we stability solution.
In our research work, we develop the analysis of a noninteger-order model for hepatitis B (HBV) under singular type Caputo fractional-order derivative. We investigated proposed system an approximate or semi-analytical solution using Laplace transform along with decomposition techniques by Adomian polynomial nonlinear terms and some perturbation Homotopy (HPM). The obtained solutions have been compared each other against real data simulation via MATLAB. graphical in fractional form shows...
Dengue is a vector-borne disease mainly affecting the tropical and subtropical regions. The transmission as well control of dengue virus not deterministic while stochastic due to various factors. We use Markovian dynamics approach describe spreading threshold disease. coexistence space composed by human mosquito populations. First, we show that there global existence positivity solution. Then, calculate basic reproduction number R0s will determine extinction or persistence If < 1, then die...