A5101566358- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Esophageal Cancer Research and Treatment
- Peripheral Artery Disease Management
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Intracranial Aneurysms: Treatment and Complications
- Vascular anomalies and interventions
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Abdominal Trauma and Injuries
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- Systemic Lupus Erythematosus Research
- Lung Cancer Treatments and Mutations
- Innovation and Knowledge Management
Nanjing Medical University
2020-2025
Fourth Hospital of Hebei Medical University
2011-2021
Hebei Medical University
2011-2021
China-Japan Friendship Hospital
2016-2020
Tianjin Medical University General Hospital
2019-2020
Nantong University
2018-2019
Affiliated Hospital of Nantong University
2018-2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2018
Peking Union Medical College Hospital
2017
Shanghai Jiao Tong University
2009-2016
Genomic landscapes of 92 adult and 111 pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) were investigated using next-generation sequencing copy number alteration analysis. Recurrent gene mutations fusions tested in an additional 87 93 patients. Among the 29 newly identified in-frame fusions, those involving MEF2D ZNF384 clinically relevant demonstrated to perturb differentiation, EP300-ZNF384 inducing mice. Eight expression subgroups associated characteristic genetic...
Transarterial chemoembolization (TACE) is an image-guided locoregional therapy used for the treatment of patients with primary hepatocellular carcinoma (HCC). However, conventional TACE formulations such as epirubicin-lipiodol emulsion are rapidly dissociated due to instability emulsion, resulting in insufficient local drug concentrations target tumor. To overcome these limitations, we biodegradable Idarubicin loaded microspheres (BILMs), which were prepared from gelatin and carrageenan...
Increasing evidence shows miR-155 plays an important role in regulating inflammatory processes systemic lupus erythematosus (SLE), especially nephritis (LN). Because the chemokine CXCL13 is implicated pathogenesis of LN, here we examined whether can modulate activity or its receptor CXCR5. We determined expression normal and MRL/lpr mice found elevated levels kidneys compared with kidneys. Besides, was mainly detected glomerulus, specifically to mesangial areas. then transfected a mimic...
This study aims to explore the regulatory role of cuproptosis in carotid intimal hyperplasia (IH), providing new insights into its pathophysiological mechanisms and potential diagnostic therapeutic strategies. Methods: We downloaded single-cell sequencing bulk transcriptome data from GEO database screen for copper-growth-associated genes (CAGs) using machine-learning algorithms, including Random Forest Support Vector Machine. After identifying relevant genes, we verified CAGs expression IH...
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disorder, and its pathogenesis in males cases without accompanying nephritis (LN-) not fully understood. In this study, we identified 90 (82 up- 8 downregulated) differentially expressed genes (DEGs) common to female LN-, LN+ male using the GSE65391 GSE49454 gene expression datasets from Gene Expression Omnibus database (GEO). The protein-protein interaction (PPI) network of 70 DEGs was constructed STRING cytoscape, ontology...
Nonfilter-associated inferior vena cava thrombosis (IVCT) is an under-recognized but severe state of venous thromboembolism. The aims this study were to investigate risk factors and develop a prediction model based on clinical data imaging findings evaluate the probability IVCT in patients with lower extremity deep vein (LEDVT).A single-center retrospective cohort was conducted. We analyzed multimodal consecutive confirmed LEDVT between February 2016 January 2022. demographics, presentation...
Inferior vena cava filter (IVCF) thrombosis is an uncommon complication of IVCF utilization. The aims this study were to investigate inferior (IVC) venography before retrieval determine the incidence relative dwell time and risk factors based on clinical data imaging findings in patients with lower extremity deep vein (LEDVT).The from a multicenter randomized trial conducted between October 2017 March 2019 reviewed preretrieval associated factors. correlation times (within 90 days) was...
Varicose veins are a common problem worldwide and can cause significant impairments in health-related quality of life, but the etiology pathogenesis remain not well defined. This study aims to elucidate transcriptomic regulations varicose by detecting differentially expressed genes, pathways regulator genes.We harvested great saphenous (GSV) from patients who underwent coronary artery bypass grafting (CABG) conventional stripping surgery. RNA-Sequencing (RNA-Seq) technique was used obtain...
Abstract Background Acute limb ischemia (ALI) is an important clinical event threatening both life and the affected limbs, but optimal treatment for ALI remains undefined. The aim of this study was to compare safety effectiveness thrombectomy approaches via either catheter-based (CBT) or catheter-directed thrombolysis (CDT). Methods A total 98 patients (mean age 69.7 years, 60 male) who underwent endovascular intervention from January 2015 July 2019 were included. Of these, 57 treated with...
To compare the efficacy and safety of AngioJet rheolytic thrombectomy (ART) large-lumen catheter suction (LCS) in treatment inferior vena cava (IVC) filter related IVC-iliac vein thrombosis. The clinical data medical imaging materials 65 cases were collected, which suffered acute thrombosis received percutaneous mechanic (PMT) from June 2016 to 2020 our center, including 32 LCS group 33 ART group. final thrombolysis rate, incidence complications, follow-up are evaluated. limb swelling was...
The arteriovenous fistula (AVF) is the first choice for vascular access hemodialysis of renal failure patients. Venous remodeling after exposure to high flow important AVF mature but mechanism underlying still unknown. objective this study identify molecular mechanisms that contribute venous AVF. To screen and differentially expressed genes (DEGs) may involve AVF, we used bioinformatics download public microarray data (GSE39488) from Gene Expression Omnibus (GEO) DEGs. We then performed gene...
The present study aimed to investigate the preliminary safety and efficacy of rheolytic thrombectomy (RT) using an AngioJet Zelante DVT catheter or a Solent Omni for acute proximal deep vein thrombosis (DVT).We conducted retrospective review 40 patients who were treated with RT between January 2019 2021, then divided into ZelanteDVT group (n = 17) 23). Data on demographics, clinical characteristics, technical success, complications, early follow-up analysed.No significant differences...
Abstract Background Del Nido cardioplegia (DNC) has been proven safe and effective in pediatric patients. However, the use of DNC adult undergoing cardiovascular surgery lacks support with substantial evidence. This study aimed to evaluate efficacy as a prophylaxis ventricular arrhythmias associated Methods recruited nine hundred fifty-four patients who underwent cardiopulmonary bypass surgeries Nanjing Hospital affiliated Medical University between January 2019 December 2019. Among 954...
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by proliferative vascular remodeling. Abnormal smooth muscle cell (VSMC) phenotype switching crucial to this process, highlighting the need for VSMC metabolic changes cover cellular energy demand in CTEPH. We report that elevated Wnt family member 5B (WNT5B) expression associated with remodeling and promotes via mitochondrial dynamics regulation Using primary culture of artery cells, we show high WNT5B activates...
Carotid artery geometry influences blood flow disturbances and is thus an important risk factor for carotid atherosclerosis. Extracellular matrix (ECM) yes-associated protein (YAP) expression may play essential roles in the pathophysiology of stenosis, but effect bifurcation location on ECM unknown. We hypothesized that anatomy are independently associated with YAP expression.In this cross-sectional study, 193 patients were divided into two groups: asymptomatic group (n = 111) a symptomatic...
Background: There are few reports in the literature on use of Glubran-2 for embolization ovarian veins patients with pelvic venous disorder (PeVD). In addition, a consensus efficacy and safety has not been reached. Purpose: To investigate vein (OVE) N-butyl-2 cyanoacrylate (NBCA) treatment PeVD. Material Methods: Between January 2013 2020, 21 women (mean age, 43.9 ± 13.3 years) PeVD who underwent OVE were evaluated. Of those patients, or plexus insufficiency was verified by duplex ultrasound...
Hepatocellular carcinoma (HCC) is a major public health threat due to its high incidence and mortality rates. Transcatheter arterial chemoembolization (TACE), the primary treatment for intermediate-to-advanced hepatocellular (HCC), commonly utilizes embolic agents loaded with anthracycline-based cytotoxic drugs. Post-TACE, hypoxic microenvironment in tumor induced by embolization stimulates formation of new blood vessels, potentially leading revascularization diminishing TACE's efficacy. In...
Purpose: Wunderlich syndrome (WS) with hypovolemic shock secondary to ruptured renal angiomyolipoma (rAML) represents an urgent condition. Hence, we reported our experience transcatheter arterial embolization (TAE) using different embolic materials under this Methods: This retrospective study consisted of 22 patients. Embolic including particles, microcoils, and liquid agents were selectively used based on the decisions interventional radiologists. Technical success was defined as complete...
The objective of this study was to investigate the risk acute kidney injury in elderly patients compared with nonelderly undergoing AngioJet rheolytic thrombectomy for treatment deep vein thrombosis.A retrospective review all who underwent thrombosis between November 1, 2014 and August 2022 conducted. Their baseline demographics, comorbidities, clinical characteristics, procedural details, postoperative course were reviewed.A total 105 eligible reviewed; 45 group, 60 group. Except age (p <...
The purpose of this study was to identify the signaling pathways and immune microenvironments related elderly stroke patients.We downloaded public transcriptome data (GSE37587) from gene expression omnibus divided patients into young old groups identified differentially expressed genes (DEGs). Gene ontology function analysis, Kyoto encyclopedia genomes pathway set enrichment analysis (GSEA) were performed. A protein-protein interaction network constructed hub identified. Gene-miRNA, gene-TF,...
This study aimed to report the clinical features and early long-term outcomes of patients treated with carotid endarterectomy (CEA) combined a routine shunt for stenosis occlusion contralateral artery (CCO), compare them without (NO-CCO).A retrospective analysis included 301 who had CEA using shunt.Of these patients, 35 266 were categorized into CCO group NO-CCO group, respectively.Demographics short-term documented compared.The demographic characteristics not significantly different between...