A5100350413- Sepsis Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- Acute Ischemic Stroke Management
- Ferroptosis and cancer prognosis
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Birth, Development, and Health
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Cardiovascular Disease and Adiposity
- Cancer therapeutics and mechanisms
- Metastasis and carcinoma case studies
- Chronic Disease Management Strategies
- Liver Disease and Transplantation
- Frailty in Older Adults
- Nutrition and Health in Aging
- Cancer-related molecular mechanisms research
- Lung Cancer Research Studies
- Pediatric Urology and Nephrology Studies
- Diet and metabolism studies
- Respiratory viral infections research
- Blood properties and coagulation
- Cancer Mechanisms and Therapy
Liverpool Heart and Chest Hospital
2023-2025
Liverpool John Moores University
2023-2025
University of Liverpool
2023-2025
Harbin Medical University
2025
Hua Medicine (China)
2025
Ji Hua Laboratory
2025
Guangzhou University of Chinese Medicine
2021-2025
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
Yueyang Hospital
2024
Effective removal of pathogenic bacteria is key to improving the prognosis sepsis. Polymorphonuclear neutrophils (PMNs) are most important components innate cellular immunity and play vital roles in clearing bacteria. However, metabolic characteristics immunomodulatory pathways PMNs during sepsis have not been investigated. In present study, we explored immune metabolism mechanism by which neutrophilic glycolysis regulated sepsis.Metabolomics analysis was performed on isolated from 14 septic...
Some observational studies found that dyslipidaemia is a risk factor for non-alcoholic fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk. However, it remains unclear whether causative NAFLD. This Mendelian randomisation (MR) study aimed to explore the causal role of lipid traits in evaluate potential effect drug targets on NAFLD.Genetic variants associated with genes encoding were extracted from Global Lipids Genetics Consortium genome-wide association (GWAS)....
To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk cardiovascular-kidney-metabolic syndrome (CKM). Data this study were from National Health Nutrition Examination Survey 1999-2018. We performed cross-sectional analyses using multinomial logistic regression to investigate relationship between OBS CKM staging. Cox proportional hazards models used assess impact on outcomes patients. Additionally, mediation explore whether mediated relationships specific...
This research sought to ascertain the relationship between hematocrit (HCT) and mortality in patients with sepsis. Methods: A retrospective analysis was conducted on clinical data of septic who were hospitalized 2008 2019 an advanced academic medical center Boston, Massachusetts, registered Medical Information Mart for Intensive Care IV (MIMIC-IV) database, We analyzed basic information including gender, age, race, types first admission, laboratory indicators HCT, platelets, white blood...
Using a data sample with total integrated luminosity of 10.0 pb$^{-1}$ collected at center-of-mass energies 2.6, 3.07 and 3.65 GeV BESII, cross sections for $e^+e^-$ annihilation into hadronic final states ($R$ values) are measured statistical errors that smaller than 1%, systematic about 3.5%. The running strong interaction coupling constants $α_s^{(3)}(s)$ $α_s^{(5)}(M_Z^2)$ determined from the $R$ values.
Abstract Background Metformin is the most frequently prescribed medication for treatment of type II diabetes mellitus and has played an anti-tumor potential in a variety cancer types. can inhibit growth many cells through various mechanisms, including ferroptosis. However, it still unclear whether metformin induce ferroptosis lung cancer. Methods This study evaluated effect by detecting levels oxidative stress factors, ferrous ions, expression ferroptosis-related genes A549 H1299 cell lines...
Orthostatic intolerance-OI is common in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-ME/CFS. We used a 10-min passive vertical lean test as orthostatic challenge-OC and measured changes vitals end tidal CO
Abstract Aims Malnutrition is increasingly recognized as a significant factor influencing the clinical outcomes of patients with heart failure (HF). Diabetes exacerbates risks like hospitalizations and mortality due to cardiovascular complications. The aim this study was explore association malnutrition diabetes its prognostic impact on all‐cause in HF, using nutritional assessment tools, controlling status (CONUT) score geriatric risk index (GNRI). Methods results Data were obtained from...
Background The association between DNA methylation age acceleration (DNAmAA) and cardiovascular‐kidney‐metabolic (CKM) syndrome stages long‐term mortality in the population with CKM remains unclear. Methods Results This cohort study included 1889 participants from National Health Nutrition Examination Survey (1999–2002) data. DNAmAA was calculated as residuals regression of on chronological age. primary outcome all‐cause mortality, cardiovascular noncardiovascular secondary outcomes....
Nonalcoholic steatohepatitis (NASH) is an increasingly prevalent liver disease associated with obesity and its complications. Recent studies have underscored a significant correlation between NASH elevated risk of cardiovascular diseases. However, the precise mechanisms inter-organ communication vascular endothelium are not fully understood. In this study, we established mouse model using methionine-choline-deficient diet to investigate role liver-derived exosomes in modulating endothelial...
Abstract Introduction: FGFR2b is a novel protein biomarker detected by IHC with the overexpression rate of ∼30% (any 2+/3+) in gastric or gastroesophageal junction cancer(GC/GEJC) patients, and among those patients ∼40% are not eligible for currently approved targeted therapies (HER2, PD-L1, MMR CLDN18.2)1. HDM2020 topoisomerase Inhibitor based DAR8 ADC developed using Ab against FGFR2b, which has potential to treat overexpressing tumor reasonable safety window2. Methods: In vivo cell line...
Diabetes ranks as the ninth leading cause of death globally, and DNA-methylation age acceleration (DNAmAA) is closely linked to lifespan. However, impact DNAmAA on long-term outcomes in specific populations with diabetes pre-diabetes has not yet been comprehensively studied. This retrospective cohort study utilized data from National Health Nutrition Examination Survey (NHANES) 1999-2002, including participants aged 20 years or older diagnosed pre-diabetes. was defined difference between...
A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However, little is known regarding the causes of CMD during NAFLD. In this study, we aimed explore role hepatic small extracellular vesicles (sEVs) in regulating endothelial microvessels NAFLD.We established two murine NAFLD models by feeding mice a methionine-choline-deficient (MCD) diet for...
Objective To determine whether the visceral adiposity index (VAI) was linked to risk of kidney stones (KS) in representative U.S. adults. Methods We investigated 59842 participants who joined 2007–2018 National Health and Nutrition Examination Survey. The association between KS identified by logistic regression analysis. Meanwhile, subgroup analysis as well calculation dose−response curves were also utilized identify sensitive groups. Results Data from 29384 available, including 2781...
Objective Coronary heart disease (CHD) is one of the major cardiovascular diseases, a common chronic in elderly and cause disability death world. Currently, intensive care unit (ICU) patients have high probability concomitant coronary artery disease, mortality this category ICU receiving increasing attention. Therefore, aim study was to verify whether composite inflammatory indicators are significantly associated with CHD develop simple personalized prediction model. Method 7115 from...
Patients with atrial fibrillation (AF) frequently experience multimorbidity. Cluster analysis, a machine learning method for classifying patients similar phenotypes, has not yet been used in South Asian AF patients.