A5079809318- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Renal and related cancers
- Renal cell carcinoma treatment
- Immune cells in cancer
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Acute Myeloid Leukemia Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Cells and Metastasis
- Parathyroid Disorders and Treatments
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Acute Lymphoblastic Leukemia research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Kruppel-like factors research
- Immune Response and Inflammation
- Plant tissue culture and regeneration
- Pancreatic function and diabetes
Sichuan University
2013-2025
Kunming Medical University
2025
Tianjin Medical University General Hospital
2024-2025
Peking University Third Hospital
2024-2025
Peking University
2020-2025
First Affiliated Hospital of Xi'an Jiaotong University
2024-2025
Xi'an Jiaotong University
2025
First Hospital of Qinhuangdao
2025
Zhongnan Hospital of Wuhan University
2018-2024
Wuhan University
2018-2024
Abstract Metastasis remains the main reason for renal cell carcinoma (RCC)–associated mortality. Tyrosine kinase inhibitors (TKI) impart clinical benefit most patients with RCC, but determinants of response are poorly understood. We report an integrated genomic and transcriptomic analysis metastatic clear RCC (ccRCC) treated TKI therapy identify predictors response. Patients in COMPARZ phase III trial received first-line sunitinib or pazopanib comparable efficacy. RNA-based analyses revealed...
Abstract Background Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival patients with lung cancer. CXCLs/CXCR2 axis plays an important role progression cancer including However, the specific anti-cancer mechanism targeting CXCR2 remains unclear. Methods Immunohistochemical analysis was performed on microarray tumor tissues clinical adenocarcinoma squamous cell carcinoma patients. CCK8 test, TUNEL immunofluorescence staining, PI-Annexin V...
Abstract The tumor-associated macrophage (TAM) is the most abundant group of immune cells in tumor microenvironment (TME), which plays a critical role regulation progression and treatment resistance. Based on different polarization status, TAMs may also induce antitumor responses or immunosuppression. present study identified JMJD6 (Jumonji domain-containing 6) as novel modulator TAM activation, upregulation was associated with immunosuppressive activities TAMs. deficiency attenuated growth...
Integrin alpha L (ITGAL) is a member of the integrin family in which abnormal expression linked with carcinogenesis and immune regulation. However, relation between ITGAL prognosis gastric cancer (GC) tumor-infiltrating lymphocytes (TILs) are not well understood. The differential expressions human tumors clinical GC were systematically analyzed via multiple databases including Gene Expression Profiling Interaction Analysis (GEPIA), UALCAN, Tumor Immune Estimation Resource (TIMER),...
Abstract The results from the RATIFY trial (ClinicalTrials.gov: NCT00651261; CALGB 10603) showed that midostaurin combined with standard chemotherapy significantly improved outcomes in patients FMS-like tyrosine kinase 3 (FLT3)–mutated acute myeloid leukemia (AML), compared placebo. In this post hoc subgroup analysis trial, we evaluated impact of 163 FLT3-tyrosine domain (TKD) mutations. At a median follow-up 60.7 months (95% CI, 55.0-70.8), 5-year event-free survival (EFS) rate was higher...
The aim of this study was to evaluate the protective effects Momordica charantia polysaccharides (MCP) on depressive-like behaviors.The chronic social defeat stress (CSDS) mice model used MCP and their underlying mechanisms. Social interaction test (SIT), sucrose preference (SPT), tail suspension (TST) were performed for behavioral assessments. Expression levels inflammation mediators phosphatidylinositol 3-kinase (PI3K) activity determined using commercial ELISA kits. expression key...
Schematic illustration of PtCo NSs for enhanced tumor radiotherapy.
Apigenin (API) is a naturally occurring plant-derived flavone, which abundantly present in common fruits and vegetables, shows little or no toxicity of daily diet. The treatment colorectal cancer limited by high recurrence rate multidrug resistance. purpose this study was to explore the potential therapeutic effect possible mechanisms API on cells. Cell proliferation apoptosis human colon cell line HCT116 assessed after treatment. A comprehensive transcriptome profile API-treated cells...
<b><i>Objective:</i></b> The present research analyzed the correlation between N6-methyladenosine (m6A) methylation and ferroptosis associated genes (FAGs) in acute kidney injury (AKI) patients. <b><i>Methods:</i></b> Bioinformatics analysis of microarray profiles (GSE30718) was performed to select differential expression (DEGs). FAGs are derived from systematic aberrances functional implications. m6A related were molecular characterization...
O-glycosylation is a widespread post-translational modification of proteins.Aberrant hallmark cancer.Here, we show that the polypeptide N-acetylgalactosamine-transferase 1 (GALNT1) frequently upregulated in gastric cancer and correlated with poor survival.Overexpression GALNT1 promoted, whereas knockdown suppressed proliferation, migration, invasion cells vitro vivo.Mechanistically, enhances aberrant initiation results CD44 glycoproteins modified abundant Tn antigens, thereby activating...
Background: Autoimmune hepatitis (AIH) is a chronic liver disease characterized by immune-mediated inflammation. Despite its global prevalence, the pathogenesis of AIH remains poorly understood, and there lack specific biomarkers targeted treatments. This study aimed to investigate role hsa_circ_0109623, hsa-miR-146b-3p, Sortilin 1 (SORT1) in their potential as therapeutic targets. Methods: We collected tissue samples peripheral blood mononuclear cells from patients with healthy controls...