A5101422840- Microfluidic and Bio-sensing Technologies
- Advanced biosensing and bioanalysis techniques
- Electrical and Bioimpedance Tomography
- Electrowetting and Microfluidic Technologies
- RNA modifications and cancer
- Microfluidic and Capillary Electrophoresis Applications
- Genetics, Aging, and Longevity in Model Organisms
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Advanced Optical Sensing Technologies
- Coronary Interventions and Diagnostics
- DNA and Nucleic Acid Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photoacoustic and Ultrasonic Imaging
- Luminescence and Fluorescent Materials
- Body Composition Measurement Techniques
- Neuroscience and Neural Engineering
- RNA Research and Splicing
- DNA and Biological Computing
- Alzheimer's disease research and treatments
- Electrohydrodynamics and Fluid Dynamics
- Nanopore and Nanochannel Transport Studies
State Key Laboratory of Transducer Technology
2021-2025
Shanghai Institute of Microsystem and Information Technology
2021-2025
Chinese University of Hong Kong, Shenzhen
2023-2025
Hunan University of Technology
2025
Chinese Academy of Sciences
2015-2024
University of Chinese Academy of Sciences
2016-2024
Guangzhou University of Chinese Medicine
2024
Northwestern University
2024
Shenzhen Institutes of Advanced Technology
2019-2024
Institute of Pharmacology
2020-2024
Abstract Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment that associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits response induced by PDT. Stimulation and proliferation T cells critical step generating responses depends on efficient presentation antigens co‐stimulatory molecules antigen‐presenting (APCs). Here, biomimetic aggregation‐induced emission (AIE) photosensitizers hitchhiking...
Abstract Glioma is one of the most common malignant tumors central nervous system, leading high mortality rates in human. Aggregation‐induced emission (AIE) photosensitizers‐based photodynamic therapy (PDT) has emerged as a promising therapeutic strategy for least‐invasive treatment glioma, which involves local irradiation tumor using an external near‐infrared (NIR) laser. Unfortunately, AIE photosensitizers suffered from poorly penetration visible light excitation, bad spatiotemporal...
Cell-free gene expression (CFE) systems enable transcription and translation using crude cellular extracts, offering a versatile platform for synthetic biology by eliminating the need to maintain living cells. However, Such are constrained cumbersome composition, high costs, limited yields due numerous additional components required biocatalytic efficiency. Here, we introduce DropAI, droplet-based, AI-driven screening strategy designed optimize CFE with throughput economic DropAI employs...
Marine organisms provide novel and broad sources for the preparations applications of biomaterials. Since urgent requirement bio‐hydrogels to mimic tissue extracellular matrix (ECM), natural biomacromolecule hydrogels derived from marine have received increasing attention. Benefiting their outstanding bioactivity biocompatibility, many attempts been made reconstruct ECM components by applying marine‐derived hydrogels. Moreover, successfully applied in biomedicine means microfluidics,...
Alzheimer's disease (AD) is rapidly reaching epidemic proportions in the United States, currently affecting more than 5 million individuals and predicted to affect 14 by 2050. Despite a general consensus that amyloid-beta (Abeta) protein plays significant role progression, underlying pathology of not entirely clear. Caenorhabditis elegans simple organism has been used as model for basic mechanistic studies on pathological processes involved AD. Previous from our labs demonstrated transgenic...
An aggregation-induced emission (AIE) active light up fluorescent probe (TCFPB-AChE) was developed for selective in vitro and vivo imaging of acetylcholinesterase activity.
Environmental toxins can result in serious and fatal damage the human heart, while development of a viable stratagem for assessing effects environmental on cardiac tissue is still challenge. Herein, we present heart-on-a-chip based induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) cultured living anisotropic structural color hydrogels cardiotoxicity screening. Such with conductive parallel carbon nanotube (CNT) upper layer, gelatin methacryloyl (GelMA) interlayer, inverse opal...
Low-cost water-soluble wash-free NIR-emissive nucleus-staining probes are crucial for exploring nucleus-related cellular events in live cells.
Exosomes, with diameters ranging from 30 to 150 nm, are saucer-shaped extracellular vesicles (EVs) secreted by various type of human cells. They present in virtually all bodily fluids. Owing their abundant nucleic acid and protein content, exosomes have emerged as promising biomarkers for noninvasive molecular diagnostics. However, the need exosome separation purification presents tremendous technical challenges due minuscule size. In recent years, microfluidic technology has garnered...
EGb 761, a standardized extract of Ginkgo biloba leaves, has been shown to have antioxidative properties. We previously demonstrated that 761 increases stress resistance and mean life span in the model organism Caenorhabditis elegans. In this study, molecular mechanism on alleviating effects oxidative is further investigated using transgenic C. elegans expressing jellyfish green fluorescent protein (GFP)-tagged inducible small heat-shock gene (hsp-16-2). The expression hsp-16-2 induced by...
Citrus fruit usually suffer significant losses during the storage and transportation stages. Green mold, a postharvest rot of citrus caused by Penicillium digitatum, is one most serious fungal diseases. In this study, antagonist strain DH-4 was identified as Bacillus amyloliquefaciens according to morphological observation 16S ribosomal DNA analysis. addition, it showed broad antifungal activity, especially suppression spp. The culture filtrate exhibited apparent activity against P....
As one of the self-luminescence imaging approaches that require pre-illumination instead real-time light excitation, afterglow luminescence has attracted increasing enthusiasm to circumvent tissue autofluorescence. In this work, we developed organic luminescent nanoprobe (nanotorch), which could emit persistent more than 10 days upon single excitation. More importantly, nanotorch be remote charged by 660 nm in a non-invasive manner, showed great potential for tracing location macrophage...
Background Proving the efficacy and corresponding mode of action herbal supplements is a difficult challenge for evidence-based therapy. A major hurdle complexity preparations, many which combine multiple herbs, particularly when combination assumed to be vitally important effectiveness This issue may addressed through use contemporary methodology validated animal models. Methods Principal Findings In this study, two commonly used traditional formulas, Shi Quan Da Bu Tang (SQDB) Huo Luo Xiao...
Ocean water column information profiles are essential for ocean research. Currently, typically obtained by lidar instruments, including spaceborne, airborne and shipborne lidar, most of which equipped with a 532 nm laser; however, blue wavelength penetrates more open detection. In this paper, we present novel dual-wavelength (DWOL), 486 laser that can operate simultaneously. This instrument was designed to compare the performance lasers in single detection area provide reference future...