A5101707256- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- High Altitude and Hypoxia
- Anesthesia and Sedative Agents
- Neuroscience of respiration and sleep
- Service-Oriented Architecture and Web Services
- Thallium and Germanium Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Heme Oxygenase-1 and Carbon Monoxide
- Epilepsy research and treatment
- Medicinal Plants and Neuroprotection
- Neurological Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Business Process Modeling and Analysis
- Semantic Web and Ontologies
- Radiopharmaceutical Chemistry and Applications
- Ion Channels and Receptors
- Pesticide Exposure and Toxicity
- Genomic variations and chromosomal abnormalities
- Sperm and Testicular Function
- Occupational exposure and asthma
Academy of Military Medical Sciences
2011-2024
Nanjing University of Chinese Medicine
2023
China Electronics Technology Group Corporation
2022
Young Invincibles
2019
Peking University
2008-2018
Dalian Maritime University
2016
Northeast Petroleum University
2013-2016
Dalian University of Technology
2014-2015
Anhui Medical University
2012
Chifeng Municipal Hospital
2012
NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR) innate immune receptor family, has been reported to participate in inflammasome formation. Activation triggers caspase-1–dependent programming cell death called pyroptosis. However, whether NLRP6 induces pyroptosis not investigated. In this study, we showed that overexpression activated caspase-1 and gasdermin-D then induced human gingival fibroblasts, resulting release proinflammatory mediators...
Abstract Idiopathic pulmonary fibrosis (IPF) poses significant challenges due to limited treatment options despite its complex pathogenesis involving cellular and molecular mechanisms. This study investigated the role of transient receptor potential ankyrin 1 (TRPA1) channels in regulating M2 macrophage polarization IPF progression, potentially offering novel therapeutic targets. Using a bleomycin-induced model C57BL/6J mice, we assessed TRPA1 inhibitor HC-030031. upregulation was observed...
<h3>Background and aims:</h3> Recurrent pancreatitis is a common complication of severe hypertriglyceridaemia in patients with various gene mutations lipoprotein lipase (LPL) or apolipoprotein CII. However, the exact pathogenetic mechanism has not yet been defined. <h3>Methods:</h3> Susceptibility to LPL-deficient mice was compared that wild-type after intraperitoneal injections caerulein by determination amylase release pancreatic pathological scores. The effect chylomicrons fatty acids on...
Background: In recent years, the impact of bacterial biofilms on traumatic wounds and means to combat them have become a major research topic in field medicine. The eradication formed by infections has always been huge challenge. Herein, we developed hydrogel with active ingredient berberine hydrochloride liposomes disrupt biofilm thereby accelerate healing infected mice. Methods: We determined ability eradicate studies such as crystalline violet staining, measuring inhibition circle,...
Postoperative cognitive dysfunction (POCD) is a clinical syndrome characterized by declines in patients after surgery. Previous studies have suggested that surgery contributed to such impairment. It has been proven neuroinflammation may exacerbate surgery-induced impairment aged rats. The free radical scavenger edaravone high blood brain barrier permeability, and was demonstrated effectively remove radicals from the alleviate development of POCD undergoing carotid endarterectomy, suggesting...
Abstract Background Sevoflurane is a superior agent for maintaining anesthesia during surgical procedures. However, the neurotoxic mechanisms of clinical concentration remain poorly understood. can interfere with normal function neurons and synapses impair cognitive by acting on α5‐GABAAR. Methods Using MWM test, we evaluated abilities in mice following 1 h 2.7%–3% sevoflurane. Based hippocampal transcriptome analysis, analyzed differential genes IL‐6 24 post‐anesthesia. Western blot RT‐PCR...
Hypoxic environments at high altitudes influence the long-term non-altitude health of residents, by inducing changes in metabolism and mitochondria, severe lung injury, endangering life. This study was aimed to determine whether meldonium can ameliorate hypoxia-induced injury investigate its possible molecular mechanisms. We used Swiss mice exposed type Ⅱ alveolar epithelial cell hypobaric hypoxic conditions induce found that has significant preventive effect, which associated with...
Paraquat (PQ) poisoning induces pulmonary fibrosisin vivo. The pathogenesis of fibrosis is complex, which has prevented the development specific treatments. Pulmonary shows several characteristics including epithelial-mesenchymal transition (EMT), fibroblast activation, and extracellular matrix (ECM) deposition. To investigate fibrosis, we designed a biomimetic multichannel micro-lung chip to imitate thein vivointerface between lung epithelium interstitium. In our model, A549 (lung...
Abstract The Multi‐Threat Medical Countermeasure (MTMC) technique is crucial for developing common biochemical signaling pathways, molecular mediators, and cellular processes. This study revealed that the Nod‐like receptor 3 (NLRP3) inflammasome pathway may be a significant contributor to cytotoxicity induced by various organophosphorus pesticides (OPPs). demonstrated exposure six different types of OPPs (paraoxon, dichlorvos, fenthion, dipterex, dibrom, dimethoate) led in BV2 cells, which...
Abstract Background Acute hypobaric hypoxia-induced brain injury has been a challenge in the health management of mountaineers; therefore, new neuroprotective agents are urgently required. Meldonium, well-known cardioprotective drug, reported to have effects. However, relevant mechanisms not elucidated. We hypothesized that meldonium may play potentially novel role hypoxia cerebral injury. Methods initially evaluated neuroprotection efficacy against acute mice and primary hippocampal...
Corona virus disease 2019 has spread worldwide, and appropriate drug design screening activities are required to overcome the associated pandemic. Using computational simulation, blockade mechanism of SARS-CoV-2 spike receptor binding domain (S RBD) human angiotensin converting enzyme 2 (hACE2) was clarified based on interactions between RBD hesperidin. Interactions anti-SARS-CoV-2 drugs therapy were investigated energy druggability compounds, they exhibited negative correlations; compounds...
Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment and Parkinson's disease (PD)-related circadian perturbations that may represent an early prodromal marker PD. Cyclin-dependent kinase 5 (CDK5) negatively regulates dopamine signaling the striatum, suggesting a critical role CDK5 sleep disorders. Here, we used clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 gene editing to produce mice with dorsal striatum (DS)-specific knockdown (KD)...
Abstract Perioperative neurocognitive disorder (PND) is a serious neurologic complication in aged patients and might be associated with sevoflurane exposure. However, the specific pathogenesis still unclear. The distribution of α5‐GABA A R, γ‐aminobutyric acid type receptor (GABA R) subtype, at extrasynaptic sites influenced by anchor protein radixin, whose phosphorylation regulated via RhoA/ROCK2 signaling pathway plays crucial role cognition. whether affects ability radixin to alter...
Brain damage caused by acute hypoxia is associated with the physiological activities of mitochondria. Although mitochondria being dynamically regulated, our comprehensive understanding response specific brain cell types to remains ambiguous. Tumor necrosis factor receptor-associated protein 1 (TRAP1), a mitochondrial-based molecular chaperone, plays role in controlling mitochondrial movements. Herein, we demonstrated that significantly alters morphology and functionality both vivo vitro...
Abstract Rationale: This is the first reported severe thallium poisoning patient successfully treated with Prussian blue (PB) and plasma exchange (PE). Patient concerns: A 42-year-old woman in a coma owing to was admitted our department after day 44 of poisoning. At admission, blood urine concentrations were 380.0 2580.0 ng/mL, respectively. Diagnosis: The diagnosed toxic encephalopathy induced by poisoning; addition, she also bilateral pneumonia, respiratory failure, moderate anemia,...