A5100630359- Plant Pathogenic Bacteria Studies
- Plant Pathogens and Fungal Diseases
- Banana Cultivation and Research
- Plant-Microbe Interactions and Immunity
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Plant Disease Resistance and Genetics
- Plant Virus Research Studies
- Glycosylation and Glycoproteins Research
- Insect-Plant Interactions and Control
- Galectins and Cancer Biology
- Estrogen and related hormone effects
- Insect Resistance and Genetics
- Circular RNAs in diseases
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Steroid Chemistry and Biochemistry
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Insect and Pesticide Research
- Cassava research and cyanide
- Genomics and Phylogenetic Studies
- Plant and Fungal Interactions Research
Zhejiang University
2025
Institute of Plant Protection
2013-2024
Guangdong Academy of Agricultural Sciences
2013-2024
Nanjing Medical University
2021-2024
Affiliated Hospital of Jiangsu University
2020-2024
Nankai University
2024
Ministry of Agriculture and Rural Affairs
2023-2024
Southern Medical University
2024
Jiangsu University
2020-2024
State Key Laboratory of Oral Diseases
2024
Abstract Background N6‐methyladenosine (m 6 A) RNA modification is known as a common epigenetic regulation form in eukaryotic cells. Emerging studies show that m A noncoding RNAs makes difference, and the aberrant expression of A‐associated enzymes may cause diseases. The demethylase alkB homologue 5 (ALKBH5) plays diverse roles different cancers, but its role during gastric cancer (GC) progression not well known. Methods quantitative real‐time polymerase chain reaction, immunohistochemistry...
Abstract Gastric cancer (GC) is a common malignant tumor worldwide, especially in East Asia, with high incidence and mortality rate. Epigenetic modifications have been reported to participate the progression of gastric cancer, among which m 6 A most abundant important chemical modification RNAs. Fat mass obesity-associated protein (FTO) first identified RNA demethylase but little known about its role cancer. In our study, data from TCGA clinical samples showed that FTO was highly expressed...
Success in anticancer immune therapy relies on stimulation of tumor antigen-specific T lymphocytes and effective infiltration the cells into tissue. Here, a therapeutic vaccine that promotes proliferation both inflamed noninflamed types is described. The consists STING agonist 2'3'-cGAMP, TLR9 ligand CpG, antigen peptides are loaded nanoporous microparticles (
Neutrophils can play a pro-tumor or anti-tumor role depending on the tumor microenvironment. The effects of concurrent treatment with granulocyte colony-stimulating factor (G-CSF) and radiotherapy (RT) neutrophils have not yet to be described.Hypofractionated radiation 8 Gy ×3 fractions was administered without recombinant G-CSF Lewis lung carcinoma tumor-bearing C57BL/6 model mice. activation status cytotoxic T cells in mice measured, along levels tumor-associated neutrophils, cells, Treg...
Dickeya zeae , a bacterial plant pathogen of the family Pectobacteriaceae, is responsible for wide range diseases on potato, maize, rice, banana, pineapple, taro, and ornamentals significantly reduces crop production. D. causes soft rot taro ( Colocasia esculenta ) heart pineapple Ananas comosus ). In this study, we used Pacific Biosciences single-molecule real-time (SMRT) sequencing to sequence two high-quality complete genomes novel strains : PL65 (size: 4.74997 MB; depth: 701x; GC: 53.6%)...
Human papillomavirus type 16 (HPV16) infects anogenital epithelia and is the etiological agent of cervical cancer. We showed previously that HPV16 infection regulates key splicing/alternative splicing factor SF2/ASF virus late transcripts are extensively alternatively spliced. hnRNP A1 antagonistic counterpart in alternative splicing. show here also up-regulated during differentiation virus-infected epithelial cells monolayer organotypic raft culture. Taken together with our previous data on...
Bacterial soft rot of banana was first noticed in 2009 Guangzhou city, China. The disease also observed on various cultivars different genotypes several other cities. Symptoms the included leaf wilting, collapse pseudostems, and unusual odor. Five isolated strains that fulfilled Koch's postulates were used for biochemical testing. five most similar to Dickeya dadantii or D. zeae, but much less paradisiaca when using phenotype characteristics. Sequence analysis 16S rDNA, dnaX, gryB, recA a...
A defence response can be induced by nonpathogenic Fusarium oxysporum CS-20 in several crops, but the molecular mechanism has not been clearly demonstrated. In present study, we analysed of a susceptible cucumber cultivar (Cucumis sativus L. 9930) against pathogen (F. f. sp. cucumerinum) through root precolonization CS-20. challenge inoculation assay indicated that disease severity index (DSI) was reduced, ranging from 18.83 to 61.67 comparison with control. Root colonization analysis did...
Ubiquitin-specific protease 7 (USP7) is a de-ubiquitin enzyme that plays an essential role in multiple cancers and becomes target for treatment. However, the of USP7 its therapeutic value HCC remains unclear.USP7 expression was examined tissues by western blot immunohistochemistry. The correlation prognosis analyzed Kaplan-Meier survival method. Mass spectrometry determined cell proliferation tumorigenicity assays were conducted vitro vivo treated P22077 sgRNA-USP7.USP7 significantly...
Purpose: Soluble cytotoxic T-lymphocyte antigen 4 (sCTLA-4), one of the isoforms CTLA-4, was discovered to be critical in downregulating negative signal CTLA-4 T-cell responses. Contrary classical immunosuppressive effect its immunoregulatory function might complicated. However, clinical significance sCTLA-4 immune regulation and variation cancer therapy have not been elucidated. We postulated that level affect outcome prognosis. Patients methods: Serum concentrations before after 141...
Stroke is the leading cause of disability and death worldwide. It severely affects patients' quality life imposes a huge burden on society in general. The diagnosis stroke relies predominantly use neuroimaging. identification using electroencephalogram (EEG) clinical assessment has been underutilized. An EEG feature fusion based light gradient-boosting machine (LightGBM) model was proposed to achieve fast non-stroke, ischemic stroke, hemorrhagic stroke. This study aims capture essential...
The black cutworm, Agrotis ipsilon (Lepidoptera: Noctuidae), is a critical soil pest of tobacco (Nicotiana tabacum) in the early season. Although numerous studies have shown that chemical insecticides through soil-surface or foliar application provide adequate management cutworms, relatively little known about efficacy transplant applications. Here, we evaluated insecticide treatment against cutworm pots and field. We also investigated impact chlorantraniliprole on tobacco, including dynamic...
We have synthesized derivatives of estradiol that are structurally modified to serve as "soft" estrogens and act within a geographically limited area the body; without systemic action. previously shown with 16α-substituted analogues carboxylates proximal steroid ring neither bind estrogen receptor nor activate estrogen-responsive genes. However, when carboxylic acid is masked an ester, they stimulate estrogenic responses. Enzymatic hydrolysis through nonspecific esterases can inactivate...
Tumor cells with genetic amplifications or mutations in the fibroblast growth factor receptor (FGFR) family are often addicted to FGFR and heavily dependent on its signaling survive. Although it is critical understand which pathway downstream of plays an essential role guide research development inhibitors, has remained unclear partly because tool compounds used literature also hit many other kinases, making results difficult interpret. With a potent FGFR-specific inhibitor, BGJ398, we now...
Velvet genes play critical roles in the regulation of diverse cellular processes. In current study, we identified gene FocVel1, a homolog Fusarium graminearum VelA, plant pathogenic fungus F. oxysporum f. sp. cucumerinum. This pathogen causes destructive disease called cucumber wilt (CFW), which severely affects production and marketing this vegetable worldwide. Transcript analyses revealed high expression FocVel1 during conidiophore development. Disruption led to several phenotypic defects,...