A5100449231- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Advanced Sensor and Energy Harvesting Materials
- Catalytic Processes in Materials Science
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Plant biochemistry and biosynthesis
- Neurological Disease Mechanisms and Treatments
- Renal and related cancers
- Medicinal Plant Pharmacodynamics Research
- Gout, Hyperuricemia, Uric Acid
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- Genomics and Phylogenetic Studies
- Geological formations and processes
- Pancreatitis Pathology and Treatment
- Pediatric Urology and Nephrology Studies
- Coastal and Marine Dynamics
First Affiliated Hospital of Anhui Medical University
2021-2025
Anhui Medical University
2021-2025
Guangzhou University of Chinese Medicine
2025
Fudan University
2017-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Stanford University
2022-2024
Houston Methodist
2016-2024
Shandong Agricultural University
2023-2024
Wake Forest University
2021-2024
Skin-attachable electronics have garnered considerable research attention in health monitoring and artificial intelligence domains, whereas susceptibility to electromagnetic interference (EMI), heat accumulation issues, ultraviolet (UV)-induced aging problems pose significant constraints on their potential applications. Here, an ultra-elastic, highly breathable, thermal-comfortable epidermal sensor with exceptional UV-EMI shielding performance remarkable thermal conductivity is developed for...
Ruthenium coordination complexes have the potential to serve as novel theranostic agents for cancer. However, a major limitation in their clinical implementation is effective tumor accumulation. In this study, we developed liposome-based nanodelivery system [Ru(phen)
Thrombolysis has been a standard treatment for ischemic stroke. However, only 2-7% patients benefit from it because the thrombolytic agent to be injected within 4.5 h after onset of symptoms avoid increasing risk intracerebral hemorrhage. As clinically approved neuroprotective drug, edaravone (EDV) rescues brain tissues by eradicating over-produced reactive oxygen species (ROS) without limitation therapeutic time-window. EDV's short circulation half-life and inadequate cerebral uptake...
Mesenchymal stem cells (MSCs) have been demonstrated to be involved in tumor progression and the modulation of microenvironment, partly through their secretome. Extracellular vesicles (EVs) are membranous nanovesicles secreted by multiple types mediate intercellular communication both physiological pathological conditions. However, numerous questions still remain regarding underlying mechanisms functional consequences these interactions. The purpose this study was investigate effects human...
Calcium oxalate (CaOx) crystal can trigger kidney injury, which contributes to the pathogenesis of nephrocalcinosis. The phenotypes infiltrating macrophage may impact CaOx-mediated inflammatory injury as well deposition. How aryl hydrocarbon receptor (AhR) regulates inflammation and polarization is understood; however, how it modulates CaOx nephrocalcinosis remains unclear. Methods: Mice were intraperitoneally injected with glyoxylate establish model or without treatment AhR activator...
Abstract Alternative splicing (AS) represents a crucial method in mRNA level to regulate gene expression and contributes the protein complexity. Abnormal has been reported play roles several diseases, including cancers. We developed OncoSplicing database for visualization of survival-associated differential alternative 2019. Here, we provide an updated version integrative view clinically relevant based on 122 423 AS events across 33 cancers TCGA SpliceSeq project 238 558 32 SplAdder project....
Tracking and imaging immune cells in vivo non-invasively would offer insights into the responses induced by vaccination. Here we report a cancer vaccine consisting of polymer-coated NaErF
mRNA delivery enables the specific synthesis of proteins with therapeutic potential, representing a powerful strategy in diseases lacking efficacious pharmacotherapies. Idiopathic pulmonary fibrosis (IPF) is chronic lung disease characterized by excessive extracellular matrix (ECM) deposition and subsequent alveolar remodeling. Alveolar epithelial type 2 cells (AEC2) fibroblasts represent important targets IPF given their role initiating driving aberrant wound healing responses that lead to...
Surgical resections of solid tumors guided by visual inspection tumor margins have been performed for over a century to treat cancer. Near-infrared (NIR) fluorescence labeling/imaging in the NIR-I (800 900 nm) range with systemically administrated fluorophore/tumor-targeting antibody conjugates introduced improve margin delineation, removal accuracy, and patient survival. Here, we show Au 25 molecular clusters functionalized phosphorylcholine ligands (AuPC, ~2 nm size) as preclinical...
An inevitable overoxidation process is considered as one of the most challenging problems in direct conversion methane (CH4) to methanol (CH3OH), which limited by uncontrollable cracking key intermediates. Herein, we have successfully constructed a photocatalyst, Fe-doped ZnO hollow polyhedron (Fe/ZnOHP), for highly selective photoconversion CH4 CH3OH under mild conditions. In-situ experiments and density functional theory calculations confirmed that introduction Fe was able decrease energy...
BackgroundIntrarenal calcium oxalate (CaOx) crystals induce inflammation and kidney tubular cell injury, which are processes that involve TLR4/NF-κB signalling. A recent genome-wide gene expression profile analysis of Randall's plaques in CaOx stone patients revealed the long noncoding RNA H19 was significantly upregulated. However, to date, its role stones has not been reported.MethodA Gene Expression Omnibus (GEO) dataset utilized analyse profiles. Luciferase reporter, Western blotting,...
Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cells (TECs) injury and inflammation, which involve Toll-like receptor 4 (TLR4)/interferon regulatory factor 1 (IRF1) signaling. Additionally, infiltrating macrophages (Mϕs) might influence intrarenal CaOx CaOx-induced injury. Although the roles of nuclear erythroid 2-related 2 (Nrf2) in regulating inflammation macrophage polarization are well characterized, its potential mechanisms nephrocalcinosis remain undefined....
SMYD2 is a histone methyltransferase that has been reported to be an important epigenetic regulator. This study aims investigate as prognostic indicator of clear cell renal carcinoma (ccRCC) and explore its role in tumorigenesis multi-drug resistance. Methods: Tumor specimens, clinicopathologic information, outcomes 186 ccRCC patients from three hospitals China were collected for immunohistochemistry staining, Kaplan-Meier analysis, Cox proportional hazards-regression analysis. MicroRNA...
Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass reduced due to diminished osteoblast activity. Stable isotope tracing vivo 13 C-glucose demonstrates glycolysis glucose fueling of TCA cycle are impaired diabetic bones. Similarly, Seahorse assays suppression oxidative phosphorylation by marrow mesenchymal cells as whole, whereas...