A5101579033- Diabetes and associated disorders
- Pancreatic function and diabetes
- Gold and Silver Nanoparticles Synthesis and Applications
- SARS-CoV-2 and COVID-19 Research
- Adrenal and Paraganglionic Tumors
- Advanced Nanomaterials in Catalysis
- Animal Virus Infections Studies
- Nanoplatforms for cancer theranostics
- Diabetes Management and Research
- Cancer, Hypoxia, and Metabolism
- Nanomaterials for catalytic reactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Reproductive Biology and Fertility
- Pituitary Gland Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Photocatalysis Techniques
- Cancer-related molecular mechanisms research
- Genetics, Aging, and Longevity in Model Organisms
- Spine and Intervertebral Disc Pathology
- RNA Research and Splicing
- Virus-based gene therapy research
- Neonatal and fetal brain pathology
Chinese PLA General Hospital
2002-2024
Columbia University Irving Medical Center
2024
New York University
2024
Cornell University
2021-2023
Liaocheng University
2021-2022
Chinese People's Liberation Army
2008-2022
Hunan First Normal University
2022
Hunan Normal University
2022
Nanjing Traditional Chinese Medicine Hospital
2021
Fudan University
2018-2020
Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification target genes lncRNAs. However, no online repository is available to collect information regulated by To make it convenient for know what are lncRNA interest, we developed database named lncRNA2Target provide comprehensive resource 2015. update this year, retrieved all new lncRNA–target relationships from papers published 1 August 2014 30...
The neuroprotective effect of ceria nanoparticles in the context brain disorders has been explained by their antioxidant effect. However, in-depth mechanism remains unknown. As resident immune cells brain, microglia exert a variety functional reprogramming termed as polarization response to stress stimuli. Herein, custom-made were developed and found scavenge multiple reactive oxygen species with extremely high efficiency. These drove microglial from pro-inflammatory phenotype an...
The ovary is the first organ to age in human body, affecting both fertility and overall health. However, biological mechanisms underlying ovarian aging remain poorly understood. Here we present a comprehensive single-nuclei multi-omics atlas of four young (ages 23–29 years) reproductively aged 49–54 ovaries. Our analyses reveal coordinated changes transcriptomes chromatin accessibilities across cell types during aging, notably mTOR signaling being prominent ovary-specific pathway....
(Abstracted from Nat Aging 2024. doi: 10.1038/s43587-024-00762-5) Ovaries are the crux of female reproductive system and first organs to show signs aging thus slowing processes, characterized by a reduced number quality oocytes. The more woman ages, higher risk infertility or aneuploidy congenital disabilities in their children.
Abstract 1‐Butyl‐3‐methylimidazolium chloride ([BMIM]Cl) was used as a solvent for cellulose, the rheological behavior of cellulose/[BMIM]Cl solution studied, and fibers were spun with dry‐jet–wet‐spinning process. In addition, structure properties prepared cellulose investigated compared those lyocell fibers. The results showed that typical shear‐thinning fluid, temperature had little influence on apparent viscosity when shear rate higher than 100 s −1 . II crystal just like fibers,...
RNA-sequencing (RNA-seq) can generate millions of reads to provide clues for analyzing novel or abnormal alternative splicing (AS) events in cells. However, current methods exploring AS are still far from being satisfactory. Here, we present Comprehensive Hunting (CASH), which constructs comprehensive splice sites including known and cells, identifies differentially between We illuminated the versatility CASH on RNA-seq data a wide range species also simulated silico data, validated...
Malignant gliomas are the most common primary brain tumors and associated with aggressive growth, high morbidity, mortality. Aberrant mesenchymal-epithelial transition factor (MET) activation occurs in approximately 30% of glioma patients correlates poor prognosis, elevated invasion, increased drug resistance. Therefore, MET has emerged as an attractive target for therapy. In this study, we developed a novel nanoinhibitor by conjugating MET-targeting cMBP peptides on G4 dendrimer. Compared...
A novel pH ratiometrically responsive surface-enhanced resonance Raman scattering (SERRS) probe was developed for tumor acidic margin delineation and image-guided surgery.
BACKGROUND: Excessively deep sedation is prevalent in mechanically ventilated patients and often considered suboptimal. We hypothesized that the bispectral index (BIS), a quantified electroencephalogram instrument, would accurately detect levels of sedation. METHODS: prospectively enrolled 90 critically ill who were receiving The BIS was monitored for 24 hours compared with Richmond Agitation Sedation Scale (RASS) evaluated every 4 hours. Deep defined as RASS −3 to −5. Threshold values...
Serving large language models (LLMs) often demands specialized hardware, dedicated frameworks, and substantial development efforts, which restrict their accessibility, especially for edge devices organizations with limited technical resources. We propose a novel compiler that translates LLM inference graphs into SQL queries, enabling relational databases, one of the most widely used mature software systems globally, to serve as runtime. By mapping neural operators such matrix multiplication...
Abstract The neuroprotective effect of ceria nanoparticles in the context brain disorders has been explained by their antioxidant effect. However, in‐depth mechanism remains unknown. As resident immune cells brain, microglia exert a variety functional reprogramming termed as polarization response to stress stimuli. Herein, custom‐made were developed and found scavenge multiple reactive oxygen species with extremely high efficiency. These drove microglial from pro‐inflammatory phenotype an...
The effect of early enteral nutrition (EN) in patients with acute pancreatitis (AP) has been confirmed. In recent years, some researchers provided new strategy that immediate EN was offered after admission. and safety unclear because the different results among studies. study aimed to implement meta analysis randomized controlled trials (RCT) confirm between group refeeding group.Four electronic databases including PubMed, EMBASE, Cochrane Library China National Knowledge Internet (CNKI)...
Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization spermatogenesis men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication frequent injections affect compliance.The aim this study was to determine efficacy sequential use highly purified urinary (uFSH)/hCG IHH.A randomized, open-label, prospective, controlled noninferiority trial 18-month follow-up conducted 9 tertiary...
GPR120 is a promising target for the treatment of type 2 diabetes (T2DM), which activated by free fatty acids (FFAs) and stimulates release glucagon-like peptide-1(GLP-1). GLP-1, as an incretin, can enhance glucose-dependent secretion insulin from pancreatic beta cells reduce blood glucose. In this study, series novel agonists were designed synthesized to improve stability hydrophilicity phenylpropanoic acid agonist TUG-891. Compound 11b showed excellent agonistic activity pharmacokinetic...
Abstract Silicon nanowire arrays (SiNWAs) are under extensive investigation for solar cells and biomedical applications. This study reports the first time that hydrogen fluoride‐treated (H)‐SiNWAs an efficient catalyst reduction of nitrobenzene derivatives. We show SiNWAs, after fluoride treatment, have a high catalytic activity in p ‐nitrophenol (PNP) reduction. The conversion rate PNP by H‐SiNWAs increases with is almost complete within 30 min, which thus indicates comparable to platinum...
The elimination of β-agonist has attracted considerable interest due to its harmfulness human health when it existed in pork.
A multicenter, open-label, randomized, controlled superiority trial with 18 months of follow-up was conducted to investigate whether oral zinc supplementation could further promote spermatogenesis in males isolated hypogonadotropic hypogonadism (IHH) receiving sequential purified urinary follicular-stimulating hormone/human chorionic gonadotropin (uFSH/hCG) replacement. Sixty-seven Chinese male IHH patients were recruited from the Departments Endocrinology eight tertiary hospitals and...
Abstract SARS-CoV-2, the cause of ongoing COVID-19 pandemic, not only infects humans but is also known to infect various species, including domestic and wild animals. While many species have been identified as susceptible there are limited studies on prevalence SARS-CoV-2 in Both non-domestic cats now established be infection by SARS-CoV-2. serious disease may occur some instances, majority infections appear subclinical. Differing data for reported, highly context-dependent. Here, we report...
Monodispersed CdS/SiO2 core-shell composite nanoparticles with effective photocatalytic activity were successfully synthesized. The structure and morphologies of characterized by XRD, FTIR, TEM, high-resolution transmission electron microscopy (HRTEM). Results showed that the exhibited obvious structure, thickness SiO2 shell could be reduced either increasing water/alcohol volume ratio or decreasing TEOS amount. prepared was determined degradation methylene blue (MB) in aqueous solution. a...
GPR120, also called FFAR4, is preferentially expressed in the intestines, and can be stimulated by long-chain free fatty acids to increase secretion of glucagon-like peptide-1 (GLP-1) from intestinal endocrine cells. It known that GLP-1, as an incretin, promote insulin pancreatic cells a glucose-dependent manner. Therefore, GPR120 potential drug target treat type 2 diabetes. In this study, thiazolidinedione derivatives were found novel potent agonists. Compound 5g, with excellent agonistic...