A5065919151- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Machine Learning in Bioinformatics
- Animal Ecology and Behavior Studies
- RNA and protein synthesis mechanisms
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Computational Drug Discovery Methods
- Esophageal Cancer Research and Treatment
- Genetic Associations and Epidemiology
- Renal and related cancers
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Genomics and Rare Diseases
- vaccines and immunoinformatics approaches
- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- RNA Research and Splicing
- Gene expression and cancer classification
- T-cell and B-cell Immunology
Affiliated Hospital of Southwest Medical University
2024-2025
Harbin Institute of Technology
2016-2024
Anshun University
2024
Guangzhou University of Chinese Medicine
2023-2024
China Medical University
2017-2023
Heilongjiang Institute of Technology
2016-2023
Zhejiang University of Technology
2021-2023
Guizhou Provincial People's Hospital
2023
Tianjin University
2021
Blacktown & Mount Druitt Hospital
2019
Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification target genes lncRNAs. However, no online repository is available to collect information regulated by To make it convenient for know what are lncRNA interest, we developed database named lncRNA2Target provide comprehensive resource 2015. update this year, retrieved all new lncRNA–target relationships from papers published 1 August 2014 30...
Abstract Pancreatic cancer (PC) is a great health burden to patients owing its poor overall survival rate. Long noncoding RNAs (lncRNAs) interact with microRNAs (miRs) participate in tumorigenesis. Therefore, we aim uncover the role and related mechanism of LINC00473 PC through modulation miR‐195‐5p programmed death‐ligand 1 (PD‐L1). Increased PD‐L1 but declined were determined tissues cell lines, it was found that mainly situated cytoplasm. Also, verified bind both PD‐L1. Next, examine...
Given the chronic inflammatory nature of Parkinson's disease (PD), T cell immunity may be important for onset. Here, we performed single-cell transcriptome and TCR sequencing, conducted integrative analyses to decode composition, function lineage relationship cells in blood cerebrospinal fluid PD. Combined expression TCR-based tracking, discovered a large population CD8+ showing continuous progression from central memory terminal effector PD patients. Additionally, identified group cytotoxic...
Abstract Accurate prediction of immunogenic peptide recognized by T cell receptor (TCR) can greatly benefit vaccine development and cancer immunotherapy. However, identifying peptides accurately is still a huge challenge. Most the antigen predicted in silico fail to elicit immune responses vivo without considering TCR as key factor. This inevitably causes costly time-consuming experimental validation test for antigens. Therefore, it necessary develop novel computational methods precisely...
Immune system plays important roles in the pathogenesis of Parkinson's disease (PD). However, role B cells this complex are still not fully understood. produce antibodies but can also regulate immune responses. In order to decode relative contribution peripheral cell subtypes etiology PD, we performed single RNA and BCR sequencing for 10,466 from 8 PD patients 6 age-matched healthy controls. We observed significant increased memory decreased naïve compared Notably, discovered IgG IgA...
The world is facing a pandemic of Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Adaptive immune responses are essential for SARS-CoV-2 virus clearance. Although large body studies have been conducted to investigate the mechanism in COVID-19 patients, we still lack comprehensive understanding BCR repertoire patients. In this study, used single-cell V(D)J sequencing characterize across convalescent We observed that diversity was...
Single-cell RNA sequencing (scRNA-seq) detects whole transcriptome signals for large amounts of individual cells and is powerful determining cell-to-cell differences investigating the functional characteristics various cell types. scRNA-seq datasets are usually sparse highly noisy. Many steps in analysis workflow, including reasonable gene selection, clustering annotation, as well discovering underlying biological mechanisms from such datasets, difficult. In this study, we proposed an method...
The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for operable gastric cancer patients; therefore, complementary factors are under intense investigation. Although the focus immune markers, impact of a single factor minimal, due to complex antitumor responses. A more comprehensive evaluation may engender accurate predictions. We analyzed by immunohistochemical staining in two independent cohorts. association with patients' survival was Kaplan-Meier...
Since the outbreak of SARS-CoV-2, etiologic agent COVID-19 pandemic, viral genome has acquired numerous mutations with potential to alter infectivity and antigenicity. Part in SARS-CoV-2 spike protein conferred virus ability spread more quickly escape from immune response caused by monoclonal neutralizing antibody or vaccination. Herein, we summarize spatiotemporal distribution protein, present recent efforts progress investigating impacts those on As continue emerge strive provide...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing an outbreak of disease 2019 (COVID-19), has been undergoing various mutations. The analysis the structural and energetic effects mutations on protein-protein interactions between receptor binding domain (RBD) SARS-CoV-2 angiotensin converting enzyme (ACE2) or neutralizing monoclonal antibodies will be beneficial for epidemic surveillance, diagnosis, optimization agents. According to molecular dynamics simulation, a key...
Alzheimer's disease (AD) and Parkinson's (PD) are the top two common neurodegenerative diseases in elderly. Recent studies found α-synuclein have a key role AD. Although many clinical pathological features between AD PD shared, genetic association them remains unclear, especially whether genetically alters risk. We did not obtain any significant result (OR = 0.918, 95% CI: 0.782–1.076, P 0.291) MR analysis In with risk, we only extracted rs356182 as IV through strict screening process. The...
Large-scale genome-wide association studies have reported EPHA1 rs11767557 variant to be associated with Alzheimer’s disease (AD) risk in the European population. However, it is still unclear how this functionally contributes underlying pathogenesis. The located approximately 3 kb upstream of gene. We think that may modify expression nearby genes such as and further cause AD risk. Until now, potential between has not been previous studies. Here, we evaluate using multiple large-scale eQTLs...
Cancer is still a severe health problem globally. The therapy of cancer traditionally involves the use radiotherapy or anticancer drugs to kill cells, but these methods are quite expensive and have side effects, which will cause great harm patients. With find peptides (ACPs), significant progress has been achieved in tumours. Therefore, it invaluable accurately identify peptides. Although biochemical experiments can solve this work, method time-consuming. To promote application therapy,...
Increasing studies have revealed that long noncoding RNAs (lncRNAs) are not transcriptional noise but play important roles in the regulation of a wide range biological processes, and dysregulation lncRNA genes is associated with disease development. Alzheimer’s (AD) chronic neurodegenerative usually starts slowly gets worse over time. However, little known about AD how transcriptionally regulated. Herein, we analyzed RNA-seq data ChIP-seq histone modification from CK-p25 model control mice...
Abstract T cells recognize tumor antigens and initiate an anticancer immune response in the very early stages of development, antigen specificity is determined by T-cell receptor (TCR). Therefore, monitoring changes TCR repertoire peripheral blood may offer a strategy to detect various cancers at relatively stage. Here, we developed deep learning framework iCanTCR identify patients with cancer based on repertoire. The uses TCRβ sequences from individual as input outputs predicted...
Abstract Background Exploring the pathogenesis of osteoarthritis (OA) is important for its prevention, diagnosis, and treatment. Therefore, we aimed to construct novel signature genes (c-FRGs) combining cuproptosis-related (CRGs) with ferroptosis-related (FRGs) explore OA aid in Materials methods Differentially expressed c-FRGs (c-FDEGs) were obtained using R software. Enrichment analysis was performed a protein–protein interaction (PPI) network constructed based on these c-FDEGs. Then,...