A5100421680- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Immune cells in cancer
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- PI3K/AKT/mTOR signaling in cancer
Fudan University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Guang’anmen Hospital
2022-2025
Yichang Central People's Hospital
2024-2025
China Three Gorges University
2024-2025
China Pharmaceutical University
2014-2025
Baylor College of Medicine
2016-2025
China Medical University
2015-2025
Peking Union Medical College Hospital
2010-2025
Shanghai Jiao Tong University
2012-2025
Adeno-associated viruses (AAV) are promising gene therapy vectors that have little or no acute toxicity. We show normal mice and with mucopolysaccharidosis VII (MPS VII) develop hepatocellular carcinoma (HCC) after neonatal injection of an AAV vector expressing b-glucuronidase. proviruses were isolated from four tumors all located within a 6-kilobase region chromosome 12. This locus encodes several imprinted transcripts, small nucleolar RNAs (snoRNAs), microRNAs. Transcripts adjacent genes...
Breast cancer is a genetically and clinically heterogeneous disease, the contributions of different target cells oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components Wnt signaling pathway contain cell types express early developmental markers, in contrast other elements. Expression Wnt-1 protooncogene glands transgenic mice expands population epithelial expressing progenitor keratin 6 Sca-1; subsequent these markers...
Background Mouse models have shown that interleukin (IL)6 stimulates survival, proliferation and progression to cancer of intestinal epithelial cells via activation signal transducers activators transcription 3 (STAT3). Objective To investigate the expression IL6/phosphorylated STAT3 (p-STAT3)/suppressor cytokine signalling (SOCS3) in biopsy specimens from patients with ulcerative colitis (UC) UC-related colorectal (CRC) progression. Methods Biopsy inactive UC (n=18), active (n=28),...
Kawasaki disease (KD) is a pediatric vasculitis that damages the coronary arteries in 25% of untreated and approximately 5% treated children. Epidemiologic data suggest KD triggered by unidentified infection(s) genetically susceptible To investigate genetic determinants susceptibility, we performed genome-wide association study (GWAS) 119 Caucasian cases 135 matched controls with stringent correction for possible admixture, followed replication an independent cohort subsequent fine-mapping,...
Abstract Objective Recently, the Th1/Th2 paradigm has been expanded by discovery of Th17 cells, a subset CD4+ memory T cells characterized their unique ability to secrete interleukin‐17 (IL‐17) family cytokines. Importantly, appear be intimately involved in autoimmunity. We undertook present study investigate whether Th17/IL‐23 system is up‐regulated Sjögren's syndrome (SS). Methods Sera, saliva, and salivary glands from C57BL/6.NOD‐ Aec1Aec2 mice (a model for primary SS), as well sera,...
Abstract Recently, chimeric antigen receptor (CAR)-T cell therapy has shown great promise in treating haematological malignancies 1–7 . However, CAR-T currently several limitations 8–12 Here we successfully developed a two-in-one approach to generate non-viral, gene-specific targeted cells through CRISPR–Cas9. Using the optimized protocol, demonstrated feasibility preclinical study by inserting an anti-CD19 CAR cassette into AAVS1 safe-harbour locus. Furthermore, innovative type of with PD1...
Evidences have shown that dysbiosis could promote the progression of colorectal cancer (CRC). However, association and prognosis CRC is barely investigated. Therefore, we used 16S rRNA gene sequencing approach to determine differences in microbiota among tumor tissues different found Fusobacterium nucleatum Bacteroides fragilis were more abundant worse groups, while Faecalibacterium prausnitzii displayed higher abundance survival group. To further explore prognostic value bacteria,...
Metastasis has been considered as the terminal step of tumor progression. However, recent genomic studies suggest that many metastases are initiated by further spread other metastases. Nevertheless, corresponding pre-clinical models lacking, and underlying mechanisms elusive. Using several approaches, including parabiosis an evolving barcode system, we demonstrated bone microenvironment facilitates breast prostate cancer cells to metastasize establish multi-organ secondary We uncovered this...
Abstract Background New therapies are urgently needed for Alzheimer’s disease (AD). Sodium oligomannate (GV-971) is a marine-derived oligosaccharide with novel proposed mechanism of action. The first phase 3 clinical trial GV-971 has been completed in China. Methods We conducted 3, double-blind, placebo-controlled participants mild-to-moderate AD to assess efficacy and safety. Participants were randomized placebo or (900 mg) 36 weeks. primary outcome was the drug-placebo difference change...
This randomized, open-label, multi-center phase 2 study (NCT03116152) assessed sintilimab, a PD-1 inhibitor, versus chemotherapy in patients with esophageal squamous cell carcinoma after first-line chemotherapy. The primary endpoint was overall survival (OS), while exploratory the association of biomarkers efficacy. median OS sintilimab group significantly improved compared (median 7.2 vs.6.2 months; P = 0.032; HR 0.70; 95% CI, 0.50-0.97). Incidence treatment-related adverse events grade 3-5...
Macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES (regulated on activation, normal T cell expressed secreted), which are the natural ligands of CC-chemokine receptor CCR5, inhibit replication MT-2- negative strains HIV-1 by interfering with ability these to utilize CCR5 as a coreceptor for entry in CD4(+) cells. The present study investigates capacity killer (NK) cells isolated from HIV-infected individuals produce CC-chemokines suppress HIV autologous, endogenously...