A5100361979- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Respiratory Support and Mechanisms
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Gallbladder and Bile Duct Disorders
- Inflammatory Biomarkers in Disease Prognosis
First Affiliated Hospital of GuangXi Medical University
2021-2025
Guangxi Medical University
2020-2025
Peking University
2008-2025
Peking University People's Hospital
2008-2025
Second People’s Hospital of Yibin
2025
Guangdong Provincial Center for Disease Control and Prevention
2020-2025
China Pharmaceutical University
2015-2025
Northern Jiangsu People's Hospital
2016-2025
Northwest A&F University
2018-2025
Zigong First People's Hospital
2025
During the outbreak of coronavirus disease 2019 (COVID-19), consistent and considerable differences in severity mortality rate patients treated Hubei province compared to those other parts China have been observed. We sought compare clinical characteristics outcomes being inside outside province, explore factors underlying these differences.
Abstract The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is major concern. It imperative to identify these early. We show that a deep learning-based survival model can predict the risk COVID-19 developing based on clinical characteristics at admission. develop this using cohort 1590 from 575 medical centers, internal validation performance concordance index 0.894 further validate three separate cohorts Wuhan, Hubei and Guangdong...
Abstract Background Gastric cancer is the third most lethal malignancy worldwide. A novel deep convolution neural network (DCNN) to perform visual tasks has been recently developed. The aim of this study was build a system using DCNN detect early gastric (EGC) without blind spots during esophagogastroduodenoscopy (EGD). Methods 3170 and 5981 benign images were collected train EGC. total 24549 from different parts stomach monitor spots. Class activation maps developed automatically cover...
Metastasis has been considered as the terminal step of tumor progression. However, recent genomic studies suggest that many metastases are initiated by further spread other metastases. Nevertheless, corresponding pre-clinical models lacking, and underlying mechanisms elusive. Using several approaches, including parabiosis an evolving barcode system, we demonstrated bone microenvironment facilitates breast prostate cancer cells to metastasize establish multi-organ secondary We uncovered this...
Camrelizumab and chemotherapy demonstrated durable antitumor activity with a manageable safety profile as first-line treatment in patients advanced esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the efficacy of camrelizumab plus neoadjuvant chemotherapy, using pathologically complete response (pCR) primary endpoint, for locally ESCC.Patients but resectable thoracic ESCC, staged T1b-4a, N2-3 (≥3 stations), M0 or M1 lymph node metastasis (confined supraclavicular...
Optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is controversial, especially in the context of potential benefit combining PD-1 blockade with neoadjuvant therapy. This phase 2 study aimed to assess camrelizumab plus chemotherapy this population. Patients (clinical stage II-IVA) received two cycles chemoimmunotherapy (NIC) (200 mg on day 1) nab-paclitaxel (260 mg/m2 total 1 and 8) cisplatin (75 days 1-3) each 21-day cycle. Surgery was performed approximately 6 weeks...
Abstract Background Conventional immunohistochemistry technologies were limited by the inability to simultaneously detect multiple markers and lack of identifying spatial relationships among cells, hindering understanding biological processes in cancer immunology. Methods Tissue slices primary tumours from 553 IA∼IIIB non‐small cell lung (NSCLC) cases stained multiplex immunofluorescence (mIF) assay for 10 markers, including CD4, CD38, CD20, FOXP3, CD66b, CD8, CD68, PD‐L1, CD133 CD163,...
Abstract Malignant pleural effusion (MPE) poses a significant challenge in local treatment, primarily attributed to its intricate tumor immune microenvironment. The immunosuppression of natural killer (NK) cells within the microenvironment, exacerbated by selenium (Se) deficiency, constitutes pivotal treatment bottleneck. Building upon prior investigations, this study delves into impact and mechanisms functionalized lentinan nanoparticles (LET‐SeNPs) on NK MPE, presenting novel strategy for...
Recombinant interferon-beta-1b (IFN-beta-1b) is used clinically in the treatment of multiple sclerosis. In common with many biological ligands, IFN-beta-1b exhibits a relatively short serum half-life, and bioavailability may be further diminished by neutralizing antibodies. While PEGylation an approach commonly employed to increase blood residency time protein therapeutics, there requisite for molecular engineering approaches also address stability, solubility, aggregation, immunogenicity...
Objective. The purposes of this study were to evaluate the feasibility, safety, and advantages nonintubated video-assisted thoracoscopic surgery (VATS) under epidural anesthesia, by comparing with performance conventional approaches. Patients methods. A total 354 patients (245 men 109 women) recruited in study. surgical procedures included bullae resection, pulmonary wedge lobectomy. anesthetic technique (epidural vs general) was selected randomly. who underwent VATS anesthesia comprised...
Rheumatoid arthritis (RA) is associated with cardiovascular disease (CVD), but little known about its association another form of vascular disorder, venous thromboembolism (VTE).A retrospective cohort study was conducted using US insurance claims. RA and non-RA patients were matched on age, sex, index date. Incidence rates (IRs) rate ratios (RRs) VTE, defined as the composite deep vein thrombosis (DVT) or pulmonary embolism (PE), calculated. Cox proportional hazards models compared VTE risks...
To comparatively assess the impact of non-intubated intravenous anaesthesia with spontaneous ventilation (NIIASV) versus intubated single-lung mechanical (IASLV) on early outcomes video-assisted thoracoscopic (VATS) anatomical resection non-small-cell lung cancer (NSCLC).A total 339 patients NSCLC undergoing VATS (282 lobectomies and 57 segmentectomies) between December 2011 2014 were included for analysis divided into two groups according to type: NIIASV (151 patients) IASLV (188 patients)....
BACKGROUND. Current clinical management of patients with pulmonary nodules involves either repeated low-dose CT (LDCT)/CT scans or invasive procedures, yet causes significant patient misclassification. An accurate noninvasive test is needed to identify malignant and reduce unnecessary tests.
Tertiary lymphoid structure (TLS) is an organized infiltration of immune cells, showing features germinal center (GC) commonly seen in secondary organs. However, its relationship with tumor-draining lymph nodes (TDLNs) has not been studied and we hypothesized that TDLN may influence maturation intratumoral TLS non-small cell lung cancer (NSCLC).Tissue slides 616 patients had undergone surgeries were examined. Cox proportional hazard regression model was used to assess risk factors patients'...
Mesoporous aluminosilicates (MAS-9) with ordered hexagonal struture have been prepared by assembly of preformed aluminosilicate precursors a triblock copolymer in strongly acidic media two-step procedure. MAS-9 exhibits extraordinarily good hydrothermal stability and high catalytic activities for the cracking both cumene 1,3,5-tri-isopropylbenzene. Even after treatment boiling water 120 h, continues to show large surface area (680 m2/g) activities. Furthermore, this strategy could be used as...
To evaluate the significance of multifocality on overall survival (OS) in patients with retroperitoneal sarcoma (RPS) and establish a data-derived, prognostically therapeutically useful definition sarcomatosis.The incidence, clinical features, prognostic RPS is unknown. No current standardized for sarcomatosis available.We conducted retrospective analysis 393 primary or recurrent nonmetastatic treated at comprehensive cancer center between 1996 2006. Baseline treatment variables were...
Abstract Purpose. Evidence from studies with small numbers of patients indicates that 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) accurately detects distant metastases in the staging primary breast cancer. We compared sensitivity and specificity PET/CT conventional imaging (CT, ultrasonography, radiography, skeletal scintigraphy) for detection Patients Methods. performed a retrospective review identified 225 cancer seen January 2000 to September 2009 whom...
In aqueous solution, host-guest complexation is frequently driven by the hydrophobic effect, which also constitutes a popular approach in design of supramolecular assemblies. Herein, we report an orthogonal assembly motif, chaotropic exploits tendency anions to associate with surfaces.