A5100742794- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Nosocomial Infections in ICU
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Cardiac Arrest and Resuscitation
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Cytomegalovirus and herpesvirus research
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Esophageal Cancer Research and Treatment
- Spinal Fractures and Fixation Techniques
- Genomics and Phylogenetic Studies
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
First Affiliated Hospital of Guangzhou Medical University
2016-2025
State Key Laboratory of Respiratory Disease
2016-2025
Guangzhou Medical University
2016-2025
Jinzhou Medical University
2024-2025
Stomatology Hospital
2024-2025
Hangzhou First People's Hospital
2015-2025
Nanjing Medical University
2019-2025
Henan University
2020-2025
China Pharmaceutical University
2025
Wenzhou Medical University
2020-2025
A novel infectious disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in Wuhan, China, December 2019.The disease (COVID-19) spread rapidly, reaching epidemic proportions and has been found 27 other countries.As of February 27, 2020, over 82,000 cases COVID-19 were reported, with > 2800 deaths.No specific therapeutics are available, current management includes travel restrictions, patient isolation, supportive medical care.There a number...
Background: The coronavirus disease 2019 (COVID-19) outbreak originating in Wuhan, Hubei province, China, coincided with chunyun, the period of mass migration for annual Spring Festival. To contain its spread, China adopted unprecedented nationwide interventions on January 23 2020. These policies included large-scale quarantine, strict controls travel and extensive monitoring suspected cases. However, it is unknown whether these have had an impact epidemic. We sought to show how control...
Early identification of patients with novel coronavirus disease 2019 (COVID-19) who may develop critical illness is great importance and aid in delivering proper treatment optimizing use resources.To validate a clinical score at hospital admission for predicting which COVID-19 will based on nationwide cohort China.Collaborating the National Health Commission China, we established retrospective from 575 hospitals 31 provincial administrative regions as January 31, 2020. Epidemiological,...
The novel coronavirus disease 2019 (COVID-19) has become a global health emergency. cumulative number of new confirmed cases and deaths are still increasing out China. Independent predicted factors associated with fatal outcomes remain uncertain.The goal the current study was to investigate potential risk from COVID-19 through multivariate Cox regression analysis nomogram model.A retrospective cohort 1,590 hospitalized patients throughout China established. prognostic effects variables,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for 2019 (COVID-19) pneumonia. Little known about kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of RT-PCR-confirmed COVID-19 were enrolled this study: 12 severely ill intensive care units who needed mechanical ventilation 11 mildly isolation wards. Serial clinical samples collected laboratory detection. Results showed that most had...
Crucial roles of hematologic and immunologic responses in progression coronavirus disease 2019 (COVID-19) remain largely unclear.We sought to address the dynamic changes biomarkers their associations with severity outcomes COVID-19.A retrospective study including 548 patients COVID-19 clarified outcome (discharged or deceased) from a national cohort China was performed. Cross-sectional longitudinal variations were compared different analyzed.On admission, counts lymphocytes, T-cell subsets,...
Abstract The sudden deterioration of patients with novel coronavirus disease 2019 (COVID-19) into critical illness is major concern. It imperative to identify these early. We show that a deep learning-based survival model can predict the risk COVID-19 developing based on clinical characteristics at admission. develop this using cohort 1590 from 575 medical centers, internal validation performance concordance index 0.894 further validate three separate cohorts Wuhan, Hubei and Guangdong...
BackgroundA novel variant of SARS-CoV-2, the Delta concern (VOC, also known as lineage B.1.617.2), is fast becoming dominant strain globally. We reported epidemiological, viral, and clinical characteristics hospitalized patients infected with VOC during local outbreak in Guangzhou, China.MethodsWe extracted epidemiological information pertaining to 159 cases across seven transmission generations between May 21 June 18, 2021. The whole chain was described. Kinetics viral load were compared a...
Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment symptoms CRS in critically ill COVID-19 important problems. We report a single-center case series 11 acute respiratory distress from First Affiliated Hospital Guangzhou Medical University China 26 January 2020 to 18 February 2020. termination date follow-up was 19 Eight were determined have characteristics CRS, including...
Abstract Background COVID-19 (coronavirus disease 2019) has caused a major epidemic worldwide; however, much is yet to be known about the epidemiology and evolution of virus partly due scarcity full-length SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) genomes reported. One reason that challenges underneath sequencing directly from clinical samples have not been completely tackled, i.e., with low viral load often results in insufficient reads for analyses. Methods We applied...
Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 deaths according to official reports. The key understanding biology and virus-host interactions SARS-CoV-2 requires knowledge mutation evolution this virus at both inter- intra-host levels. However, despite quite a few polymorphic sites identified among populations, variant spectra their evolutionary dynamics remain mostly unknown.Using high-throughput sequencing...
Abstract Oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), but an estimated 50% patients will eventually stop responding to due acquired resistance. This study revealed that diminished MEIS1 expression was detected CRC and harmed survival patients. impaired cell viabilities tumor growth mice enhanced sensitivity oxaliplatin by preventing DNA damage repair. Mechanistically, resistance following suppression critically dependent on FEN1 expression. Subsequently,...