A5006625246- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Prosthetics and Rehabilitation Robotics
- Stroke Rehabilitation and Recovery
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Muscle activation and electromyography studies
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Cancer Immunotherapy and Biomarkers
- Radiation Therapy and Dosimetry
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Long-Term Effects of COVID-19
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- Ergonomics and Musculoskeletal Disorders
- Esophageal Cancer Research and Treatment
- Economic and Financial Impacts of Cancer
Wuhan University
2015-2025
Renmin Hospital of Wuhan University
2015-2025
Henan University of Science and Technology
2015-2024
Luoyang Cement Engineering Design and Research Institute
2024
Jilin University
2023
Shanghai Cancer Institute
2023
Hubei Cancer Hospital
2020
Imaging Center
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2016
Chinese People's Liberation Army
2015
Abstract Colorectal cancer (CRC) is a heterogeneous disease that develops through stepwise accumulation, yet the underlying mechanisms at single-cell resolution remain unclear. Here, we profiled 751,531 transcriptomes, spatial transcriptomics, and snMultiomes from 142 multistage samples, revealing cellular molecular alterations dynamic intercellular crosstalk during CRC development. Additionally, created sc-eQTL map identifying 16,833 significant pairs across 28 cell subtypes, with over 76%...
The outbreak of Coronavirus Disease 2019 (COVID-19) has become a global public health emergency.
Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi without BRCA mutations, but underlying mechanism not clear. Here, we report that deubiquitylating enzyme USP15 affects cancer cell response to regulating HR. Mechanistically, recruited DNA double-strand breaks (DSBs) MDC1, which requires FHA domain MDC1...
The objective of this study was to detect the expression MiR-21-5p in non-small-cell lung cancer (NSCLC) tissues, and investigate effect its on progression NSCLC.Real-time fluorescent quantitative PCR used relative 118 NSCLC tumor tissues their adjacent normal tissues. expressions SMAD7, MMP-9, E-cadherin, vimentin proteins were detected by Western blotting or immunohistochemistry. Cell colony formation, scratch, Transwell assays proliferation, migration, invasion ability A549 cells,...
A human–robot interactive control is proposed to govern the assistance provided by a lower limb exoskeleton robot patients in gait rehabilitation training. The training with two exoskeletons driven pneumatic proportional servo system and has rotational degrees of freedom each limb. An adaptive admittance model adopted considering its suitability for interaction. law parameters designed Sigmoid function reinforcement learning algorithm. Individualized suitable are obtained learning....
The implementation of a progressive rehabilitation training model to promote patients’ motivation efforts can greatly restore damaged central nervous system function in patients. Patients’ active engagement be effectively stimulated by assist-as-needed (AAN) robot training. However, its application robotic therapy has been hindered simple determination method robot-assisted torque which focuses on the evaluation only affected limb’s movement ability. Moreover, expected effect assistance...
Abstract Background Early detection of colorectal neoplasms can reduce the cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking personalized CRC early screening in East Asian (EAS) population. We aimed to develop, validate, and optimize a comprehensive model across all stages dynamic adenoma-carcinoma sequence EAS Methods To develop precision risk-stratification strategies, we developed three trans-ancestry PRSs targeting...
Abstract Background To evaluate the efficacy and outcomes of hypofractionated stereotactic radiotherapy (HSRT) for brain metastases > 3 cm. Methods From March 2003 to October 2009, 40 patients with larger than cm were treated by HSRT. HSRT was applied in 29 primary treatment 11 rescue. Single metastasis detected 21 patients. Whole incorporated into 10 treatment. boosts 23 The diameters ranged from 3.1 5.5 (median, 4.1 cm). median prescribed dose (not including boosts) Gy (range, 20-53 Gy)...
Abstract This study aims to investigate the role of long noncoding RNA SNHG20 in progression nonalcoholic fatty liver disease (NALFD) hepatocellular carcinoma (HCC), and elucidate whether polarization Kupffer cells (KCs, macrophages) was involved this process. Mouse NALFD induced by 16 weeks high‐fat diet (HFD) feeding. NALFD‐HCC 36 HFD feeding (from 1 week weeks) 20 diethyl nitrosamine (DEN) administration 17 weeks). The LV‐shRNA‐ LV‐sh‐SNHG20‐infected RAW264.7 were injected into mice...
Purpose This study aims to evaluate whether survival outcomes for GIST patients have improved over the past decades and identify specific patient subgroups that benefited from advances in treatment. Patients methods A total of 4,127 diagnosed between January 1980, December 2019, were included this using data Surveillance, Epidemiology, End Results (SEER)-9 Registries. Survival differences among analyzed across five time periods (1980–1999, 2000–2004, 2005–2009, 2010–2014, 2015–2019) within...
Background and objective(s) This study evaluates the accuracy of automatic segmentation Organs at Risk (OARs) in nasopharyngeal carcinoma (NPC) using three approaches: atlas-based, 2D U-Net, a self-developed Trident network. Our aim was to develop, validate, compare performance network for precise delineation NPC our center’s dataset, comparison conventional atlas-based U-Net techniques. Materials methods We randomly selected 209 patients with this retrospective study, OARs manually...
Background Extra-gastrointestinal stromal tumor (EGIST) is a rare subtype of gastrointestinal tumor, with limited information on its clinical characteristics and prognostic factors. This study aims to identify the risk factors affecting survival in EGIST patients develop nomogram for predicting EGIST-specific (TSS). Methods Patients diagnosed EGIST, aged 18 80, were enrolled from Surveillance, Epidemiology, End Results (SEER) Research Plus database, covering years 2000 2019. Univariate...
This research focuses on developing a safe, lightweight, power assist device that can be worn by people during lifting or static holding tasks to prevent them from experiencing Low Back Pain (LBP). In consideration of their flexibility, light weight, and large force weight ratio, two types pneumatic actuators are employed in assisting low back movement for safety comfort. Actuator A is an elongation-type rubber artificial muscle installed the outer layer garment. Its ends fixed shoulders...
This study is aimed at systematically analyzing the expression, function, and prognostic value of six transmembrane epithelial antigen prostate 1 (STEAP1) in various cancers. The expressions STEAP1 between normal tumor tissues were analyzed using TCGA GTEx. Clinicopathologic data was collected from GEPIA TCGA. Prognostic analysis conducted by Cox proportional hazard regression Kaplan-Meier survival. DNA methylation, mutation features, molecular subtypes cancers also investigated. top-100...
Ovarian cancer (OC) is a malignancy exhibiting high mortality in female tumors. Glycosylation posttranslational modification of proteins but research has failed to demonstrate systematic link between glycosylation-related signatures and tumor environment OC. This study aimed at developing novel model with messenger RNAs (GRmRNAs) predict the prognosis immune function OC patients. The transcriptional profiles clinical phenotypes patients were collected from Gene Expression Omnibus Cancer...