A5003312656- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cancer Immunotherapy and Biomarkers
- Solid State Laser Technologies
- Venous Thromboembolism Diagnosis and Management
- Ferroptosis and cancer prognosis
- Photorefractive and Nonlinear Optics
- Cancer Research and Treatments
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Epilepsy research and treatment
- Coronary Interventions and Diagnostics
- Peptidase Inhibition and Analysis
- Advanced Fiber Laser Technologies
- Cancer, Lipids, and Metabolism
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Laser Design and Applications
Daping Hospital
2000-2025
Army Medical University
2025
Renmin Hospital of Wuhan University
2016-2025
Wuhan University
2016-2025
Jiangxi University of Traditional Chinese Medicine
2022-2025
Nantong University
2024-2025
Guilin University of Technology
2019-2025
Wenzhou Medical University
2025
First Affiliated Hospital of Wenzhou Medical University
2025
Second Affiliated Hospital of Nanchang University
2025
Tumor cells gain a survival/growth advantage by adapting their metabolism to respond environmental stress, process known as metabolic transformation. The best-known aspect of transformation is the Warburg effect, whereby cancer up-regulate glycolysis under aerobic conditions. However, other mechanisms mediating remain undefined. Here we report that carnitine palmitoyltransferase 1C (CPT1C), brain-specific enzyme, may participate in CPT1C expression correlates inversely with mammalian target...
Significance Humanized mice represent a promising approach to study the human immune system in health and disease. However, insufficient development function of lymphocytes limit applicability humanized for cancer biology therapy. We demonstrate that SIRPA IL15 knock-in (SRG-15) support efficient circulating tissue-resident natural killer (NK) cells, intraepithelial lymphocytes, innate lymphoid cell subsets. In contrast previous mouse models, NK cells SRG-15 mediate antibody-dependent...
Abstract Objective: Triple-negative breast cancer (TNBC) involves higher rates of recurrence and distant metastasis. The present study sought to characterize the risk factors for metastasis TNBC. Methods: Surveillance, Epidemiology, End Results (SEER) database was exploited enroll patients diagnosed with TNBC from 2010 2015. eligible were dichotomized into locoregional at time diagnosis. Patients’ demographics tumor features, treatment evaluated identify primary categorical variables...
Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations. There is also clinical evidence for the utility of PARPi without BRCA mutations, but underlying mechanism not clear. Here, we report that deubiquitylating enzyme USP15 affects cancer cell response to regulating HR. Mechanistically, recruited DNA double-strand breaks (DSBs) MDC1, which requires FHA domain MDC1...
Limited evidence exists on the combined and mediating effects of systemic inflammation association between insulin resistance cardiovascular events in patients with diabetes chronic coronary syndrome (CCS). This secondary analysis a multicenter prospective cohort included 4419 diabetic CCS patients. Triglyceride–glucose index (TyG) high-sensitivity C-reactive protein (hsCRP) were applied to evaluate inflammation, respectively. The primary endpoint was major adverse cardiac event (MACE)....
Abstract Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery systems for are promising OA therapy. In this study, we reported an M1 macrophage-targeted system Bai@FA-UIO-66-NH 2 based on folic acid (FA) -modified metal-organic framework (MOF) loaded with baicalin (Bai) antioxidant agent With outstanding biocompatibility high loading efficiency, could be specifically uptaken by LPS-induced macrophages...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
RNA modifications, including methylation, are widely existed in cutaneous melanoma (CM). Among epigenetic N7-methylguanosine (m7G) is a kind of modification at 5â cap which participate maintaining the stability mRNA and various cell biological processes. However, there still no study concerning relationship between CM m7G methylation complexes, METTL1 WDR4. Here, long non-coding (lncRNAs) gene expression data from Cancer Genome Atlas (TCGA) database were retrieved to identify...
Tumor-derived extracellular vesicles (EVs) are promising to monitor early stage cancer. Unfortunately, isolating and analyzing EVs from a patient's liquid biopsy challenging. For this, we devised an EV membrane proteins detection system (EV-MPDS) based on Förster resonance energy transfer (FRET) signals between aptamer quantum dots AIEgen dye, which eliminated the extraction purification conveniently diagnose lung In cohort of 80 clinical samples, this showed enhanced accuracy (100% versus...
Abstract Background Stress hyperglycemia ratio (SHR), a novel biomarker of stress hyperglycemia, was proved to be reliable predictor short‐term adverse outcomes in patients with acute coronary syndromes (ACS). However, its impact on long‐term prognosis remained controversial. Methods A total 7662 ACS from large nationwide prospective cohort between January 2015 and May 2019 were included. SHR calculated by the following formula: = admission glucose (mmol/L)/(1.59 × HbA1c [%]−2.59). The...
Symptomatic hypotension is the most frequent complication in patients receiving haemodialysis (HD). Previous studies have reported that use of modulating dialysate sodium concentration or ultrafiltration (UF) rates, combination profile and UF may better preserve blood volume reduce incidence hypotensive episodes. The aim this study was to evaluate effects balance-neutral their on preservation volume, cardiac function occurrence episodes.Using Fresenius MC 4008S, eight stable HD underwent...
In the present study, anxiolytic and sedative-hypnotic activities of polygalasaponins extracted from Polygala tenuifolia Willdenow (Polygalaceae) were determined in mice using hole-board, elevated plus maze, open field, sodium pentobarbital-induced hypnosis tests. Moreover, acute toxicity was also estimated mice. Sixty minutes after p.o. administration (40, 80, 160 mg/kg) mice, central crossing counts percentage central/total ambulation significantly increased number rearings defecations...
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
Nucleotide de novo synthesis is essential to cell growth and survival, its dysregulation leads cancers drug resistance. However, how this pathway dysregulated in cancer has not been well clarified. This study aimed identify the regulatory mechanisms of nucleotide resistance.By combining ChIP-Seq data from Cistrome Data Browser, RNA sequencing (RNA-Seq) a luciferase-based promoter assay, we identified transcription factor FOXK2 as regulator synthesis. To explore biological functions cancers,...
The development of space exploration technologies puts higher demand on power systems. reactor gas turbine cycle (SRGTC) has the advantages compact configuration and small mass volume is one optimal options for future high-power SRGTC operates in an isolated island state radiator fragile if it hit by asteroids debris. transient characteristics are fundamental safe operation loss accidents. In this paper, a dynamic model established, performance with dual conversion unit (PCU) modules...