A5025897748- Cerebrospinal fluid and hydrocephalus
- Glioma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Epilepsy research and treatment
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Fetal and Pediatric Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Pain Mechanisms and Treatments
- Pelvic and Acetabular Injuries
- Growth Hormone and Insulin-like Growth Factors
- Functional Brain Connectivity Studies
Cliniques Universitaires Saint-Luc
2015-2024
Medical University of Vienna
2024
Centre Hospitalier Interrégional Edith Cavell
2023-2024
UCLouvain
2014-2023
Hospital Infantil Universitario Niño Jesús
2023
Leefmilieu Brussel
2000-2019
Bicêtre Hospital
2008
May Institute
2006
Province of Antwerp
2000
KU Leuven
2000
Cabergoline is a new long-acting dopamine agonist that very effective and well tolerated in patients with pathological hyperprolactinemia. The aim of this study was to examine, large number hyperprolactinemic patients, the ability normalize PRL levels cabergoline, determine dose tolerance, assess effect on clinical symptoms, tumor shrinkage, visual field abnormalities. We also evaluated effects cabergoline subgroup bromocriptine intolerance or -resistance. retrospectively reviewed files 455...
Adequate postoperative management of nonfunctioning pituitary macroadenomas (NFMAs) remains a challenge for the clinician.To identify predictive factors NFMA relapse after initial surgery.This retrospective study included 142 patients operated an in two academic centers (CHU Bicêtre France and UCL St Luc Belgium). The rate tumor relapse, defined as recurrence total surgical resection or regrowth remnant, well was analyzed.During mean follow-up 6.9 years, 10 out 42 (24%) who had complete...
Few studies have recently re-examined the efficacy of neurosurgery in prolactinoma patients operated for various indications. To analyze outcomes with a treated by transsphenoidal surgery, to identify factors associated remission and relapse, evaluate if surgical debulking allows better hormonal control preoperative resistance dopamine agonists (DAs). This was retrospective review benign followed preoperatively postoperatively our department surgery (n=63; 45 women; mean age: 31±14 years)....
IDIOPATHIC NORMAL-PRESSURE HYDROCEPHALUS remains difficult to treat. Controversy exists as whether or not shunting can really improve cognitive functions and quantified intracranial pressure monitoring (ICP-Mo) predict postoperative improvement rates. Several studies have drawn attention the lack of a prospective study concerning surgical outcome this condition. We performed such on idiopathic normal-pressure hydrocephalus patients shunted basis ICP-Mo when "high" waves (amplitude >9 mm Hg)...
The insula, particularly its posterior portion, is often regarded as a primary cortex for pain. However, this interpretation largely based on reverse inference, and specific involvement of the insula in pain has never been demonstrated. Taking advantage high spatiotemporal resolution direct intracerebral recordings, we investigated whether human exhibits local field potentials (LFPs) Forty-seven insular sites were investigated. Participants received brief stimuli belonging to four different...
X-linked acrogigantism (X-LAG) syndrome is a newly described form of inheritable pituitary gigantism that begins in early childhood and usually associated with markedly elevated GH prolactin secretion by mixed adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GHRH levels have been elevated. We performed series hormonal profiles young female sporadic patient subsequently undertook vitro studies primary tumor...
Additional robust criteria to predict early postoperative recurrence of non-functioning pituitary macroadenomas (NFMAs) are needed. Recently, a new classification tumors has been proposed, which is based on both radiological and histological allows the grading into 5 groups different potential aggressiveness. The aim this study was use further characterize predictive factors in an independent series NFMA.120 patients operated for NFMA were analyzed retrospectively. For each them, invasion...
The mainstay of treatment for symptomatic or large chronic subdural hematoma (CSDH) is surgery, but controversy still exists regarding the best surgical technique. Three different techniques are commonly used: burr hole craniostomy (BHC), minicraniotomy (MC), and twist drill (TDC).To determine which technique drainage CSDH offers results.We set up a multicenter prospective randomized trial (Comparison Chronic Subdural Hematoma Treatment [COMPACT] trial) comparing BHC, MC, TDC CSDH. primary...
FROM 1986 TO 1989, 23 adult patients (average age, 70 yr) with idiopathic chronic hydrocephalus received shunts medium-pressure Pudenz-Schulte valves for suspected normal pressure hydrocephalus. Prospective clinical and computed tomographic monitoring was continued at least 5 years. We observed the formation of a hypodense subdural collection in each 10 (43%). Those collections that occurred early, i.e., within first 9 postoperative days, evolved differently from those late; only early...
Abstract Between January 1984 and December 1990. 65 intramedullary spinal cord tumors were diagnosed operated on. In this series, all patients underwent magnetic resonance imaging investigations on with the Cavitron ultrasonic surgical aspirator whenever necessary. Major difficulties have been found in previously treated by radiotherapy or without biopsy. We to be a highly sensitive procedure method of choice for visualizing within cord. Nevertheless, accurate diagnosis may only suggested...
In this case report we describe a of propofol infusion syndrome in an adult after short-term large-dose during neurosurgical procedure. Large-dose (9 mg.kg(-1).h(-1)) was given for only 3 h surgery and followed by small-dose (2.3 20 postoperatively. The patient had also received large doses methylprednisolone. He developed marked lactic acidosis with mild biological signs renal impairment rhabdomyolysis but no cardiocirculatory failure. There were other evident causes as documented...
Volume-controlled ventilation has been suggested to optimize lung deposition during nebulization although promoting spontaneous is targeted avoid ventilator-induced diaphragmatic dysfunction. Comparing topographic aerosol volume-controlled and in pressure support never performed. The aim of this study was compare a radiolabeled generated with vibrating-mesh nebulizer invasive mechanical ventilation, two modes: ventilation. Seventeen postoperative neurosurgery patients without pulmonary...
Transient nociceptive stimuli elicit robust phase-locked local field potentials (LFPs) in the human insula. However, these responses are not preferential for nociception, as they also elicited by transient non-nociceptive vibrotactile, auditory, and visual stimuli. Here, we investigated whether another feature of insular activity, namely gamma-band oscillations (GBOs), is preferentially observed response to Although nociception-evoked GBOs have never been explored insula, previous scalp...
IntroductionIn the PROMISE study, a multinational randomized controlled trial (RCT) of effectiveness spinal cord stimulation (SCS) with multicolumn surgical leads as treatment low back pain, clinicians followed their usual practice. An early, unplanned safety analysis revealed that infection rate in Belgium (5/23), where duration was median 21.5 days, significantly higher than 1/64 observed other study countries (median 5.8 p < 0.01). This report reviews infections after completion.Materials...
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
OBJECTIVE Recent reports in the literature have described a significant discrepancy adverse outcomes between coil embolization (CE; 10%) and surgical clipping (SC; 25%) for management of unruptured intracranial aneurysms (UIA). This led us to analyze our experience. METHODS In 1996, we designed prospective study patients with UIA which CE was considered treatment choice performed if interventional neuroradiologists deemed aneurysm's fundus-to-neck ratio accessible CE. SC only complete...
Recent reports have shown promising short- to medium-term results in patients with refractory idiopathic intracranial hypertension (IIH) treated using the stereotactic ventriculoperitoneal shunting (SVPS) technique. However, long-term clinical efficacy of this technique remains questionable. This report provides SVPS treating IIH patients.We reviewed medical charts nine consecutive (mean age, 26.4 yr; range, 4-63 yr) either a frame-based or frameless for IIH.The mean postoperative follow-up...
Gross total or near resection (GTR/NTR; ≥95%) of glioblastoma (GBM) seems correlated with a longer survival. Intraoperative MRI (ioMRI) is one method to evaluate the extent (EOR) in order improve it during same anesthesia. We compared GBM resections using 3.0T ioMRI and then without considering EOR, safety, survival discussed indications for this expensive modality.Between March 2006 November 2011, 56 were performed an ioMRI, 38 (control group). The only criterion have access was its...
This work presents a prospective morphological and quantitative analysis of 43 intracranial pressure recordings performed on normal hydrocephalic patients. led us to separate Lundberg's B waves into different subtypes refine the definition 'Plateau' wave. Two wave named Great Symmetrical Intermediate appeared correlated with surgical improvement. In addition, degree post-operative improvement was frequency An extended classification is proposed that can be used alone determine which patients...