A5101771332- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Cancer, Lipids, and Metabolism
- Coronary Interventions and Diagnostics
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Imaging and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Diet, Metabolism, and Disease
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Cerebrovascular and Carotid Artery Diseases
- Blood properties and coagulation
- Atrial Fibrillation Management and Outcomes
- Renal and Vascular Pathologies
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Linguistic research and analysis
- Cardiovascular Issues in Pregnancy
- Neurological Disease Mechanisms and Treatments
- Parathyroid Disorders and Treatments
- Phytochemical and Pharmacological Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
University of Zurich
2024-2025
Fu Wai Hospital
2021-2024
State Key Laboratory of Cardiovascular Disease
2023
Peking Union Medical College Hospital
2021-2022
Guangzhou Eighth People's Hospital
2020
Guangzhou Medical University
2020
First Affiliated Hospital of Henan University
2017
Hebei Medical University
2016
First Affiliated Hospital of Hebei Medical University
2016
Abstract Background Inflammation plays a crucial role in coronary atherosclerosis progression, and growing evidence has demonstrated that the fibrinogen-to-albumin ratio (FAR), as novel inflammation biomarker, is associated with severity of artery disease (CAD). However, long-term risk cardiovascular events remains indistinct patients different level FAR glycemic metabolism status. This study was to assess 5-year clinical outcomes diabetic non-diabetic who underwent percutaneous intervention...
Limited evidence exists on the combined and mediating effects of systemic inflammation association between insulin resistance cardiovascular events in patients with diabetes chronic coronary syndrome (CCS). This secondary analysis a multicenter prospective cohort included 4419 diabetic CCS patients. Triglyceride–glucose index (TyG) high-sensitivity C-reactive protein (hsCRP) were applied to evaluate inflammation, respectively. The primary endpoint was major adverse cardiac event (MACE)....
ABSTRACT Background Guideline‐recommended PARIS thrombotic risk score predicts coronary thrombosis events (CTE) in Acute Coronary Syndrome (ACS) patients undergoing Percutaneous Intervention. We aim to evaluate whether D‐dimer, a biomarker, can predict long‐term adverse and improve the prognostic value of score. Methods Results This is post‐hoc analysis on prospective cohort 10,724 Chinese PCI. Patients who presented as ACS were included stratified according baseline D‐dimer level (cutoff...
Abstract Background and Aims Circulating proenkephalin (PENK) is a stable endogenous polypeptide with fast response to glomerular dysfunction tubular damage. This study examined the predictive value of PENK for renal outcomes mortality in patients acute coronary syndromes (ACS). Methods Proenkephalin was measured plasma prospective multicentre ACS cohort from Switzerland (n=4787) validation cohorts UK (n=1141), Czechia (n=927), Germany (n=220). A biomarker-enhanced risk score (KID-ACS score)...
Uterine corpus endometrial carcinoma (UCEC) is one of the leading causes death from gynecological cancer due to high recurrence rate. A recent study indicated that molecular biomarkers can enhance prediction power if they were integrated with clinical information. In this study, we attempted identify a new multi-RNA-type-based biomarker for predicting risk and recurrence-free survival (RFS). Matched mRNA (including lncRNA) miRNA RNA-sequencing data 463 UCEC patients (n = 75, recurrent; n...
ABSTRACT Pulmonary arterial hypertension (PAH) poses significant clinical management challenges due to gaps in understanding its global epidemiology. We analyzed PAH‐related disability‐adjusted life years (DALYs), deaths, and prevalence from 1990 2021. Age‐period‐cohort models regression analyses assessed temporal trends projected burdens 2050. Globally, DALYs declined by 6.6%, but increased 13.9% high socio‐demographic index (SDI) countries. Middle SDI regions reported the highest Deaths...
Residual thrombosis risk is an important contributor to ischaemic events in patients with acute coronary syndrome (ACS) after percutaneous intervention (PCI). Although previous studies have shown that rivaroxaban 2.5 mg two times per day ACS high can significantly reduce the of recurrence and mortality, individualised treatment low-dose still rare. Using D-dimer PARIS (Patterns non-Adherence Anti-Platelet Regimen Stented Patients) score identify at risk, we aim investigate whether 3-month...
Few studies have characterized long-term exposure to lipoprotein(a), or Lp(a), different glucose metabolism status, and their joint role in adverse cardiovascular outcomes risk. We consecutively enrolled 10,724 coronary heart disease (CAD) patients from January December 2013 Fuwai Hospital. Associations of cumulative lipoprotein(a) (CumLp(a)) status with major cardiac cerebrovascular events (MACCEs) risk were evaluated using Cox regression models. Compared participants normal regulation lower CumLp(
Abstract Background Total occlusion is the most severe coronary lesion, indicating heavy ischemic burden and poor prognosis. The lipid profile central to development of atherosclerotic lesions. Evidence on optimal measure be monitored managed in patients with established artery disease (CAD) inconclusive. Methods cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL-c), nonhigh-density (non-HDL-c), (a) [Lp(a)], apolipoprotein B (apoB), non-HDL-c/HDL-c, apoB/apoA-1 were...
Patients with coronary artery disease (CAD) at low residual inflammatory risk are often overlooked in research and practice. This study examined the associations between fourteen indicators all-cause mortality 5,339 CAD patients baseline high-sensitivity C-reactive protein (hsCRP) <2 mg/L who received percutaneous intervention statin aspirin therapy. The median follow-up time was 2.1 years. Neutrophil-derived systemic response index (SIRI) yielded strongest most robust association among all...
Lipoprotein(a) [Lp(a)] and renal dysfunction are both independent risk factors for cardiovascular disease. However, it remains unclear whether function mediates the association between Lp(a) outcomes in patients undergoing percutaneous coronary intervention (PCI). From a large prospective cohort study, 10 435 eligible PCI from January 2013 to December were included our analysis. Patients stratified into three groups according their baseline estimated glomerular filtration rate (eGFR) (<60;...
Background Lipoprotein(a), or Lp(a), has been recognized as a strong risk factor for atherosclerotic cardiovascular disease. However, the relationship between Lp(a) and bleeding remains indistinct, especially in secondary prevention population of coronary artery disease (CAD). This investigation aimed to evaluate association with long-term among patients CAD. Methods Based on prospective multicenter cohort CAD consecutively enrolled from January 2015 May 2019 China, current analysis included...
This study explored the ability of high-sensitivity C-reactive protein (hs-CRP) and glycosylated hemoglobin A1c (HbA1c) to predict adverse cardiac cerebrovascular outcomes in patients with chronic coronary syndromes (CCS) undergoing percutaneous intervention (PCI).
Background: Despite substantial improvement in chronic total occlusions (CTO) revascularization technique, the long-term clinical outcomes diabetic patients with revascularized CTO remain controversial. Our study aimed to investigate 5-year cardiovascular survival for or without type 2 diabetes mellitus (DM) who underwent successful percutaneous coronary intervention (PCI) CTO. Methods: Data of current analysis derived from a large single-center, prospective and observational cohort study,...
To the Editor: Despite optimal secondary prevention treatments, a large proportion of patients with coronary artery disease (CAD) after percutaneous intervention (PCI) are still at high risk recurrent cardiovascular events. Inflammation is well-known component residual and contributes to progression atherosclerosis, leading destabilization rupture atheroma plaques.[1] As downstream protein in activated inflammatory pathway that mediates high-sensitivity C-reactive (hsCRP) widely used as...
<b><i>Introduction:</i></b> Limited data are available on the long-term impact of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60–89 mL/min/1.73 m<sup>2</sup>) in patients with three-vessel coronary disease (3VD). <b><i>Methods:</i></b> A total 5,272 3VD undergoing revascularization were included and categorized into 3 groups: normal function (eGFR ≥90 m<sup>2</sup>, <i>n</i> = 2,352),...