A5067387423- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Sirtuins and Resveratrol in Medicine
- Protease and Inhibitor Mechanisms
- Cardiovascular Function and Risk Factors
- Bone and Dental Protein Studies
- Inflammasome and immune disorders
- Fatty Acid Research and Health
- Neurological Disease Mechanisms and Treatments
- Lipid metabolism and disorders
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Health and Disease Prevention
- Antiplatelet Therapy and Cardiovascular Diseases
- Diet and metabolism studies
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Genoa
2016-2025
Ospedale Policlinico San Martino
2016-2025
University of Zurich
2017-2023
University of Geneva
2021
University Hospital of Zurich
2019
Swiss Integrative Center for Human Health
2019
Creative Research Enterprises (United States)
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2017
Alleanza Contro il Cancro
2016
Sapienza University of Rome
2013
Abstract The ongoing worldwide increase in life expectancy portends a rising prevalence of age-related cardiovascular (CV) diseases the coming decades that demands deeper understanding their molecular mechanisms. Inflammation has recently emerged as an important contributor for CV disease development. Indeed, state chronic sterile low-grade inflammation characterizes older organisms (also known inflamm-ageing) and participates pivotally development frailty, disability, most degenerative...
Metabolic cardiomyopathy (MC)—characterized by intra-myocardial triglyceride (TG) accumulation and lipotoxic damage—is an emerging cause of heart failure in obese patients. Yet, its mechanisms remain poorly understood. The Activator Protein 1 (AP-1) member JunD was recently identified as a key modulator hepatic lipid metabolism mice. present study investigates the role obesity-induced MC. transcriptional activity increased hearts from diet-induced (DIO) mice associated with myocardial TG...
CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) arterial thrombosis. Hence, present study explored potential link between IL-1β, NETs, and tissue factor (TF)—the key trigger coagulation cascade—in atherothrombosis. To end, ST-elevation...
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its shedding product [soluble LOX-1 (sLOX-1)] are implicated in atherosclerotic cardiovascular disease (ASCVD) pathogenesis. Herein, we examined the relationship of sLOX-1 with both fatal events plaque progression patients acute coronary syndromes (ACS).Plasma was assessed at baseline ACS chronic syndrome (CCS) prospectively recruited multicentre SPUM-ACS study, sex- age-matched healthy subjects serving as additional...