A5088872496- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Inflammatory mediators and NSAID effects
- Infective Endocarditis Diagnosis and Management
- Galectins and Cancer Biology
- Takotsubo Cardiomyopathy and Associated Phenomena
- Diet and metabolism studies
- Inflammatory Biomarkers in Disease Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- Gastrointestinal disorders and treatments
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
Kantonsspital Baselland
2023-2024
University Hospital of Zurich
2015-2023
Kantonsspital Aarau
2020-2023
Zurich Heart House
2015-2019
University of Zurich
2015-2018
Systemic levels of trimethylamine N-oxide (TMAO), a pro-atherogenic and pro-thrombotic metabolite produced from gut microbiota metabolism dietary (TMA)-containing nutrients such as choline or carnitine, predict incident cardiovascular event risks in stable primary secondary prevention subjects. However, the prognostic value TMAO setting acute coronary syndromes (ACS) remains unknown.We investigated relationship with among sequential patients presenting ACS two independent cohorts. In...
Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts 1,162), we discovered structurally identified a plasma metabolite associated with cardiovascular disease (CVD) risks, N6,N6,N6-trimethyl-L-lysine (trimethyllysine, TML). Stable-isotope-dilution tandem mass spectrometry analyses of independent validation cohort 2,140) confirmed TML levels are independently incident (3-year) major adverse event risks (hazards ratio [HR], 2.4; 95% CI, 1.7-3.4)...
Background ECG criteria differentiating Takotsubo cardiomyopathy (TTC) from mainly anterior myocardial infarction (MI) have been suggested; however, this was in small patient populations. Methods and Results Twelve‐lead admission ECGs of consecutive 200 TTC MI patients were compared dichotomized groups based on the presence or absence ST‐elevation (STEMI versus STE‐TTC non‐ST elevation non ST‐elevation‐TTC). When comparing STEMI STE‐TTC, –aVR characteristic with a sensitivity/specificity 43%...
Abstract Aims We aimed to evaluate the frequency, clinical features, and prognostic implications of cardiac arrest (CA) in takotsubo syndrome (TTS). Methods results reviewed records patients with CA known heart rhythm from International Takotsubo Registry. The main outcomes were 60-day 5-year mortality. In addition, predictors mortality during acute TTS phase assessed. Of 2098 patients, 103 included. Compared without CA, more likely be younger, male, have apical TTS, atrial fibrillation...
Abstract Aims Trimethyllysine (TML) serves as a nutrient precursor of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and is associated with incident cardiovascular (CV) events in stable subjects. We examined relationship between plasma TML levels CV patients presenting acute coronary syndromes (ACS). Methods results Plasma were quantified two independent cohorts using mass spectrometry, its was investigated. In Cleveland Cohort (N = 530), comprised to emergency...
The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its shedding product [soluble LOX-1 (sLOX-1)] are implicated in atherosclerotic cardiovascular disease (ASCVD) pathogenesis. Herein, we examined the relationship of sLOX-1 with both fatal events plaque progression patients acute coronary syndromes (ACS).Plasma was assessed at baseline ACS chronic syndrome (CCS) prospectively recruited multicentre SPUM-ACS study, sex- age-matched healthy subjects serving as additional...
Background: Left atrial appendage occlusion (LAAO) is mostly performed by transesophageal echocardiography (TEE) guidance. Intracardiac (ICE) may be an alternative imaging modality for LAAO that precludes the need general anesthesia or sedation. Methods and Results: All consecutive single center, operator candidates were analyzed. Baseline clinical procedural characteristics in‐hospital outcomes compared between patients in whom a Watchman was implanted with ICE vs. TEE In 76 device deployed...
Abstract Background Patients with ST-segment elevation typically feature total coronary occlusion (TCO) of the infarct-related artery (IRA) on angiography, which may result in worse outcomes. Yet, relying solely electrocardiogram (ECG) findings be misleading and those presenting non-ST-segment acute syndromes (NSTE-ACSs) have TCO as well. Herein, we aimed to delineate clinical characteristics outcomes patients ACS stratified by IRA location. Methods A 4787 were prospectively recruited...
Abstract Aims Outcomes after acute coronary syndromes (ACS) are determined by baseline risk profiles, including initial systolic blood pressure (sBP) levels. Herein, we aimed to characterize ACS patients stratified sBP levels and study their relation inflammation, myocardial injury post-ACS outcomes. Methods results We analysed 4724 prospectively recruited according invasively assessed (<100, 100–139, ≥140 mmHg) at admission. Biomarkers of systemic inflammation [high-sensitivity...
Residual shunt following percutaneous patent foramen ovale (PFO) closure has been described in up to 49% of patients and is associated with recurrent cerebrovascular events. Our aim was evaluate the safety, feasibility, midterm outcomes transcatheter residual closure.From 1994 July 2016, 2,679 underwent PFO for treatment presumed paradoxical embolism at our institution. Among them, 100 (3.7%) were referred closure. They constituted study population which a retrospective analysis...
Abstract Background Inflammatory processes can trigger acute coronary syndromes (ACS) which may increase core body temperature (BT), a widely available low‐cost marker of systemic inflammation. Herein, we aimed to delineate baseline characteristics ST‐segment elevation myocardial infarction (STEMI) and non‐ST‐segment ACS (NSTE‐ACS) patients stratified by initial BT assess its predictive utility towards major adverse cardiovascular events (MACE) after the index ACS. Methods From 2012 until...
Background Conventional surgical risk scores lack accuracy in stratification of patients undergoing transcatheter aortic valve replacement (TAVR). Elevated levels midregional proadrenomedullin (MR-proADM) are associated with adverse outcome not only manifest chronic disease states, but also the general population. Objectives We investigated predictive value MR-proADM for mortality an unselected contemporary TAVR Methods prospectively included 153 suffering from severe stenosis who underwent...
The aim of the study was to evaluate occurrence, duration and impact time delays primary percutaneous coronary intervention (pPCI) in ST-segment elevation myocardial infarction (STEMI).A total 357 consecutive STEMI patients enrolled prospective Special Program University Medicine ACS (SPUM-ACS) cohort were included. In order identify causes behind a possible treatment delay, we constructed four different points which included: 1) symptom onset hospital arrival, 2) arrival catheterization...
Aims . To assess the incremental prognostic value of SYNTAX score II (SxSII) as compared to anatomical Score (SxS) and GRACE risk in patients with acute coronary syndromes who underwent percutaneous intervention. Methods results SxSII SxS were determined 734 ACS patients. Patients enrolled prospective Special Program University Medicine COMFORTABLE AMI cohorts later on stratified according tertiles (SxSII Low ≤21.5 (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Abstract Background Post‐procedural risk stratification based on renal function after trans aortic valve implantation (TAVI) was assessed by means of a modified age, creatinine, and ejection fraction (ACEF) score using the lowest glomerular filtration rate (GFR), obtained within 1 week implantation. We refer to as ACEF‐7 score. Methods The Zurich‐ Cardiocentro Ticino TAVI‐Cohorts comprised 424, 137 patients, who were not hemodialysis had already survived first post‐procedural week. Zurich...
Abstract The clinical benefits of renal denervation are still under discussion, since randomized controlled studies have provided inconsistent results. present retrospective study examined the effects with focus on office blood pressure, heart rate, and changes in function. Patients treatment‐resistant hypertension (blood pressure ≥ 140/90 mm Hg spite 3 antihypertensive drugs including a diuretic) underwent at University Hospital Zurich, Switzerland were followed up until 36 months. Renal...
The number of elderly patients undergoing coronary revascularization is steadily increasing, and data on the impact gender outcomes are scarce. This study sought to assess gender-related differences in with acute syndromes (ACS).We investigated ACS referred for angiography prospectively enrolled Swiss Cohort between December 2009 October 2012. Adjudicated major adverse cardiovascular cerebrovascular events (MACCE) included all-cause death, non-fatal myocardial infarction, clinically...
Aim: Cystatin C, neutrophil gelatinase-associated lipocalin and galectin-3 have emerged as biomarker candidates to predict cardiovascular outcomes mortality in the general population well patients with coronary artery or renal disease. However, their predictive role clinical utility acute syndromes alone combination beyond currently used risk scores remains be determined. Methods results: lipocalin, were measured plasmas of 1832 at time presentation requiring percutaneous intervention bypass...
A 56-year-old, asymptomatic patient with a history of coronary artery disease, previously treated percutaneously and permanent atrial fibrillation the CHA2DS2-Vasc-score 3, arrived at our hospital for routine transoesophageal echocardiography (TEE) control, 6 months after implantation 24-mm-AMPLATZER-Cardiac-Plug (ACP). The left appendage (LAA) had been initially implanted to reduce risk …
Background: Colorectal cancer (CRC) is a common and potentially preventable malignancy. Evidence has emerged that coronary artery disease patients are at increased risk for developing CRC by shared factors. Here we investigated an association between atrial fibrillation (AF), surrogate marker of cardiovascular risk, in the setting routine screening colonoscopy. Methods: We 1949 asymptomatic participants (median age 61 [54–67] years, 49% females) undergoing colonoscopy within SAKKOPI registry...
BackgroundPatients with atrial fibrillation undergoing transcatheter aortic valve implantation (TAVI) have a worse prognosis than those in sinus rhythm. The bleeding risk associated oral anticoagulation accounts for some of this difference. Left appendage occlusion (LAAO) omits the need patients fibrillation. We investigated feasibility simultaneous TAVI and LAAO Lotus Watchman compared results to both interventions as stand-alone procedures.MethodsFifty-two consecutive who underwent either...