Jaana Hartiala
A5041705829- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Birth, Development, and Health
- Diet and metabolism studies
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Protein Tyrosine Phosphatases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Air Quality and Health Impacts
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Drug Transport and Resistance Mechanisms
University of Southern California
2016-2025
Keck Hospital of USC
2008-2025
Southern California University for Professional Studies
2012-2019
Center for Non-Communicable Diseases
2017
University of Cambridge
2017
University of Leicester
2017
University of Pennsylvania
2017
Duke University
2013
Cleveland Clinic Lerner College of Medicine
2012
Cleveland State University
2011-2012
Coronary heart disease (CHD) is the leading cause of mortality in African Americans. To identify common genetic polymorphisms associated with CHD and its risk factors (LDL- HDL-cholesterol (LDL-C HDL-C), hypertension, smoking, type-2 diabetes) individuals ancestry, we performed a genome-wide association study (GWAS) 8,090 Americans from five population-based cohorts. We replicated 17 loci previously or Caucasians. For these regions (CHD: CDKN2A/CDKN2B; HDL-C: FADS1-3, PLTP, LPL, ABCA1),...
Causes of autism are unknown. Associations with maternal nutritional factors and their interactions gene variants have not been reported.Northern California families were enrolled from 2003 to 2009 in the CHARGE (CHildhood Autism Risks Genetics Environment) population-based case-control study. Children aged 24-60 months evaluated confirmed (n = 288), spectrum disorder 141), or typical development 278) at University California-Davis Medical Investigation Neurodevelopmental Disorders Institute...
Objective— Diminished serum paraoxonase and arylesterase activities (measures of paraoxonase-1 [PON-1] function) in humans have been linked to heightened systemic oxidative stress atherosclerosis risk. The clinical prognostic use measuring distinct PON-1 has not established, the genetic determinants are known. Methods Results— We established analytically robust high-throughput assays for measured these 3668 stable subjects undergoing elective coronary angiography without acute syndrome were...
Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts 1,162), we discovered structurally identified a plasma metabolite associated with cardiovascular disease (CVD) risks, N6,N6,N6-trimethyl-L-lysine (trimethyllysine, TML). Stable-isotope-dilution tandem mass spectrometry analyses of independent validation cohort 2,140) confirmed TML levels are independently incident (3-year) major adverse event risks (hazards ratio [HR], 2.4; 95% CI, 1.7-3.4)...
Elevated levels of plasma trimethylamine N-oxide (TMAO), the product gut microbiome and hepatic-mediated metabolism dietary choline L-carnitine, have recently been identified as a novel risk factor for development atherosclerosis in mice humans. The goal this study was to identify genetic factors associated with TMAO levels.We used comparative genome-wide association approaches discover loci A hybrid mouse diversity panel locus on chromosome 3 (P=2.37 × 10(-6)) that colocalized highly...
Abstract Metabolites derived from dietary choline and L -carnitine, such as trimethylamine N -oxide betaine, have recently been identified novel risk factors for atherosclerosis in mice humans. We sought to identify genetic associated with plasma betaine levels determine their effect on of coronary artery disease (CAD). A two-stage genome-wide association study (GWAS) two significantly loci chromosomes 2q34 5q14.1. The lead variant 2q24 (rs715) localizes carbamoyl-phosphate synthase 1 ( CPS1...
Abstract Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform multi-stage genome-wide association study (max N = 289,038) principally in East Asians meta-analysis Europeans. We report 19 new ancestry-specific variants, conforming to common variant model. At 10 unique loci, distinct non-rare variants colocalize within the same linkage disequilibrium block despite significantly discordant effects...
Abstract Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis animal models. Components NLRP3 pathway such as interleukin-1β can therapeutically be targeted. Associations genetically determined inflammasome-mediated systemic inflammation with CVD and mortality humans are unknown. Methods results We explored association genetic variants prevalent 538 167...
Individuals with features of metabolic syndrome are particularly susceptible to severe acute respiratory coronavirus 2 (SARS-CoV-2), a novel associated the disease, disease 2019 (COVID-19). Despite considerable attention dedicated COVID-19, link between and SARS-CoV-2 infection remains unclear. Using data from UK Biobank, we investigated relationship severity COVID-19 syndrome-related serum biomarkers measured prior infection. Logistic regression analyses were used test biomarker levels...
BACKGROUND: COVID-19 is associated with acute risk of major adverse cardiac events (MACE), including myocardial infarction, stroke, and mortality (all-cause). However, the duration underlying determinants heightened cardiovascular disease MACE post–COVID-19 are not known. METHODS: Data from UK Biobank was used to identify cases (n=10 005) who were positive for polymerase chain reaction (PCR + )-based tests SARS-CoV-2 infection (n=8062) or received hospital-based International Classification...
Variation in transcription factor 7-like 2 (TCF7L2) gene has been shown to be associated with type diabetes and diabetes-related quantitative traits. We examined variation a 0.1-Mb region surrounding marker DG10S478 for association traits 132 Mexican-American families of proband previous gestational mellitus (GDM).Study participants were phenotyped by an oral glucose tolerance test (OGTT) intravenous dual-energy X-ray absorptiometry scan percentage body fat. Of the 42 tag single nucleotide...
A gain-of-function R620W polymorphism in the PTPN22 gene, encoding lymphoid tyrosine phosphatase LYP, has recently emerged as an important risk factor for human autoimmunity. Here we report that another missense substitution (R263Q) within catalytic domain of LYP leads to reduced activity. High-resolution structural analysis revealed molecular basis this loss function. Furthermore, Q263 variant conferred protection against systemic lupus erythematosus, reinforcing proposal inhibition...