A5061291986- Genetic Associations and Epidemiology
- Oral microbiology and periodontitis research
- Lipoproteins and Cardiovascular Health
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Genetic Mapping and Diversity in Plants and Animals
- Streptococcal Infections and Treatments
- Acute Ischemic Stroke Management
- Genetic and phenotypic traits in livestock
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Adipokines, Inflammation, and Metabolic Diseases
- Blood Pressure and Hypertension Studies
- Immune Response and Inflammation
- RNA modifications and cancer
- Heart Rate Variability and Autonomic Control
- Acute Myocardial Infarction Research
- Dental Radiography and Imaging
- Cardiac Valve Diseases and Treatments
Helsinki University Hospital
2016-2025
University of Helsinki
2016-2025
Hospital District of Helsinki and Uusimaa
2019-2025
Universitat Autònoma de Barcelona
2024-2025
Hospital Universitario Virgen de la Arrixaca
2024
ERN GUARD-Heart
2023
Lung Institute
2018-2021
Institute for Molecular Medicine Finland
2014-2020
Finnish Institute for Health and Welfare
2014-2017
Center for Non-Communicable Diseases
2017
The ESC Guidelines represent the views of and were produced after careful consideration scientific medical knowledge, evidence available at time their publication.The is not responsible in event any contradiction, discrepancy, and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies.Health professionals are encouraged take fully into account when exercising clinical...
The aim was to study the prognostic value of plasma ceramides (Cer) as cardiovascular death (CV death) markers in three independent coronary artery disease (CAD) cohorts.Corogene is a prospective Finnish cohort including stable CAD patients (n = 160). Multiple lipid biomarkers and C-reactive protein were measured addition Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0), Cer(d18:1/24:1). Subsequently, association between high-risk CV mortality investigated Special Program University...
Reports on the retention of somatic cell memory in induced pluripotent stem cells (iPSCs) have complicated selection optimal type for generation iPSC biobanks. To address this issue we compared transcriptomic, epigenetic, and differentiation propensities genetically matched human iPSCs derived from fibroblasts blood, two tissues most practical relevance biobanking. Our results show that lines same donor are highly similar to each other. However, genetic variation imparts a donor-specific...
Low-density lipoprotein (LDL) particles cause atherosclerotic cardiovascular disease (ASCVD) through their retention, modification, and accumulation within the arterial intima. High plasma concentrations of LDL drive this disease, but quality may also contribute. Here, we focused on intrinsic propensity to aggregate upon modification. We examined whether inter-individual differences in are linked with lipid composition coronary artery (CAD) death, basic mechanisms for plaque growth...
The aims were to analyze whether the levels of self-reported bruxism and anxiety associate among otherwise healthy subjects, investigate independent effects stress experience on probability bruxism.As part a study irregular shift work, questionnaire was mailed all employees Finnish Broadcasting Company with work (number subjects: n=750) an equal number randomly selected in same company regular eight-hour daytime work.The response rates 82.3% (56.6 % men) 34.3 (46.7 men), respectively. Among...
Abstract Aim Chronic periodontitis has an episodic and multifactorial character, with fluctuations in bacterial burden, inflammatory response, tissue destruction. We investigated the association of selected salivary biomarkers periodontal parameters validated use a novel diagnostic approach, cumulative risk score ( CRS ), detection subjects angiographically verified coronary artery disease diagnosis. Materials Methods The concentrations matrix metalloproteinase MMP )‐8, interleukin IL )‐1 β...
Missing teeth have been linked to incident cardiovascular disease, diabetes, and all-cause mortality. Our previous study revealed that signs of oral infections inflammatory conditions (i.e., periodontal disease dental caries) are associated with disadvantageous features circulating metabolites. This investigates whether missing tooth loss, the end points these diseases, similar metabolic features. The 2 Finnish population-based studies Health-2000 ( n = 6,197) FINRISK-97 6,050) were...
Abstract Background Highly expressed in skeletal muscles, the gene Obscurin ( i.e. OBSCN) has 121 non-overlapping exons and codes for some of largest known mRNAs human genome. Furthermore, it plays an essential role muscle development function. Mutations OBSCN are associated with several hypertrophic cardiomyopathies muscular disorders. undergoes extensive complex alternative splicing, which is main reason that its splicing regulation cardiac not previously been thoroughly studied. Methods...
Psychosocial stress is a potentially modifiable risk factor of early-onset ischemic stroke, with limited evidence suggesting stronger association between and cryptogenic stroke (CIS) compared strokes known etiology. We aimed to explore the self-perceived CIS, subgroup analyses stratified by sex age. Young patients aged 18-49 years first-ever CIS sex-matched age-matched stroke-free controls from 19 European centers were included. Self-perceived was assessed using modified version Perceived...
Background — Coronary artery disease, an inflammatory may be caused by infection. We investigated whether the antibiotic clarithromycin would reduce morbidity and mortality in patients with acute non–Q-wave coronary syndrome. Methods Results Altogether, 148 infarction or unstable angina were randomly assigned to receive double-blind treatment either placebo for 3 months. The primary end point was a composite of death, myocardial infarction, during treatment; secondary occurrence any...
Abstract Introduction We investigated the association of periodontitis and severity coronary artery disease ( CAD ) as verified using angiography. Material Methods Participants were recruited among those attending angiography at Helsinki University Central Hospital, Finland, in 2007 2008. Detailed clinical periodontal examination [number teeth, bleeding on probing, probing depth PPD )] oral panoramic radiographs [alveolar bone loss ABL ), angular defects] performed. Results Of 506 patients,...
An endodontic lesion (EL) is a common manifestation of infection where Porphyromonas endodontalis frequently encountered. EL may associate with increased risk for coronary artery disease (CAD) via similar pathways as marginal periodontitis. The aim this cross-sectional study was to delineate the associations between and CAD. Subgingival P. endodontalis, its immune response, serum lipopolysaccharide were examined potential mediators these 2 diseases. Finnish Parogene consists 508 patients...
The X chromosome (chrX) represents one potential source for the “missing heritability” complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate benefits of including chrX GWAS by assessing contribution 404,862 SNPs to levels twelve commonly studied cardiometabolic and anthropometric traits 19,697 Finnish Swedish individuals with replication data on 5,032 additional Finns. By using a linear mixed model, estimate that average...