A5074359421- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Peripheral Artery Disease Management
- Cardiovascular Function and Risk Factors
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Cerebrovascular and Carotid Artery Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Diet, Metabolism, and Disease
- Chronic Kidney Disease and Diabetes
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Risk Factors
- Lipid metabolism and disorders
- Cardiac Imaging and Diagnostics
- Sphingolipid Metabolism and Signaling
- Cardiovascular Health and Disease Prevention
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
Private University in the Principality of Liechtenstein
2016-2025
Vorarlberg Institute for Vascular Investigation and Treatment
2016-2025
Landeskrankenhaus Feldkirch
2014-2023
Central Research Laboratories (United Kingdom)
2023
Drexel University
2018
University of Regensburg
2003-2012
Institute of Medical Microbiology and Hygiene
2008-2009
As synthetic biology advances, labeling of genes or organisms, like other high-value products, will become important not only to pinpoint their identity, origin, spread, but also for intellectual property, classification, bio-security legal reasons. Ideally information should be inseparably interlaced into expressed genes. We describe a method embedding messages within open reading frames by adapting steganographic algorithms typically used watermarking digital media files. Text are first...
Background: Uromodulin is the most abundant protein in urine. Low uromodulin has been found associated with diabetes as well chronic kidney disease (CKD). Whether it also predicts a future decline function not known. Methods: We evaluated association between serum and 529 patients performed genome-wide study. Clinical parameters including renal were determined at baseline reassessed 4-year follow-up visit. Results: Patients' levels highest polymorphism UMOD coding region significantly...
Obesity is characterized by the rapid expansion of visceral adipose tissue, resulting in a hypoxic environment tissue which leads to profound change gene expression adipocytes. As consequence, there dysregulation metabolism and adipokine secretion leading development systemic inflammation finally onset metabolic diseases. The flavonoid quercetin as well other secondary plant metabolites also referred phytochemicals have anti-oxidant, anti-inflammatory, anti-diabetic effects known be...
Metabolomics, with its wealth of data, offers a valuable avenue for enhancing predictions and decision-making in diabetes. This observational study aimed to leverage machine learning (ML) algorithms predict the 4-year risk developing type 2 diabetes mellitus (T2DM) using targeted quantitative metabolomics data. A cohort 279 cardiovascular patients who underwent coronary angiography were initially free T2DM according American Diabetes Association (ADA) criteria was analyzed at baseline,...
Hypoxia in adipose tissue is suggested to be involved the development of a chronic mild inflammation, which obesity can further lead insulin resistance. The effect hypoxia on gene expression adipocytes appears play central role this inflammatory response observed obesity. However, global impact transcriptional changes human unclear. Therefore, we compared profiles Simpson-Golabi-Behmel syndrome (SGBS) under normoxic or hypoxic conditions detect hypoxia-responsive genes by using whole genome...
The novel adipokine chemerin, encoded by the RARRES2 gene, has been suggested to be linked insulin resistance and metabolic syndrome (MetS). However, no well-defined cardiovascular profile reported association with coronary artery disease (CAD) is a matter of debate. Because there relation between renal dysfunction CAD, we analyzed plasma chemerin levels estimated glomerular filtration rate (eGFR) in 495 patients undergoing angiography for evaluation established or suspected stable CAD....
Summary Introduction The JAK 2 V617F mutation is highly prevalent in patients with myeloproliferative neoplasms ( MPN ). Several studies have shown that allele burden correlates hematologic characteristics and clinical end‐points . Allele‐specific real‐time quantitative polymerase chain reaction RQ ‐ PCR ) probably the most commonly used technique for detection quantitation of mutation. Alternatively, digital an emerging technology absolute DNA quantitation, which based on dilution...
Background: Glypican-4 (GPC4) is a cell-surface heparan sulfate proteoglycan that can be released into circulation under various clinical conditions. Elevated levels of circulating GPC4 have recently been associated with reduced kidney function and an increased risk all-cause mortality across different patient populations. The potential for assessing disease status or prognosis in patients end-stage has not yet explored was addressed the present study. Methods: study included 187 starting...
We have cloned and characterized a single copy C. reinhardtii gene containing an open reading frame of 333 nucleotides encoding 12.7 kDa protein. The novel protein, DIP13, exhibits 60% identity with two mammalian proteins, human NA14 unnamed mouse Homologous sequences are also present in several protozoan, trematode fish genomes, but no homologs been found the completed genomes yeast, Drosophila, elegans A. thaliana. By using specific antibody we localized DIP13 to microtubule structures,...
The human immunodeficiency virus type 1 (HIV-1) protease (PR) has recently been shown to be inhibited by its propeptide p6* in vitro. As itself is a PR substrate, the primary goal of this study was determine importance cleavage for HIV-1 maturation and infectivity. For that purpose, short peptide variants mimicking proposed sites within flanking were designed analyzed qualitative quantitative hydrolysis Proviral clones comprising selected site mutations established Gag Pol processing,...
To elucidate the complex impact of hypoxia on adipose tissue, resulting in biased metabolism, insulin resistance and finally diabetes we used mature adipocytes derived from a Simpson-Golabi-Behmel syndrome patient for microarray analysis. We found significantly increased transcription rate genes involved glycolysis striking association between pattern upregulated disease biomarkers mellitus resistance. Although their upregulation turned out to be HIF-1α-dependent, identified further factors...
Uromodulin is the most abundant urine protein under physiological conditions. It has recently been described as a serum and plasma marker for kidney disease. Whether uromodulin associated with impaired glucose metabolism unknown. We therefore measured traits in cohort of 529 consecutively recruited patients. Serum was significantly inversely correlated fasting (r = −0.161; P < 0.001), 2 hours after an oral 75 g challenge −0.158; HbA1c −0.103; 0.018). A total 146 (27.6%) our patients had type...
Cholesterol-based risk prediction is often insufficient in cardiovascular disease (CVD) patients. Ceramides are a new kind of biomarkers for CVD. The Coronary Event Risk Test (CERT) validated predictor that uses only circulating ceramide levels, determined by coupled liquid chromatography-mass spectrometry, to allocate patients into one four categories. This test has recently been modified (CERT2) additionally including phosphatidylcholine levels.In this observational cohort study, we have...
Blood pressure (BP) varies over a lifetime. This cardiovascular observation study (OS) compared the predictive value of earlier- and later-in-life blood in 1,497 disease patients utilizing readings taken during health survey (HS) 15 years later from same subjects at baseline this OS. Prediction risk OS follow-up (21 years) was significantly more effective if earlier BP HS were used instead recent (NRI = 0.30, p < 0.001). For readings, each 10 mm Hg increase systolic diastolic associated with...
Abstract Mutational analysis of circulating tumour (ct) DNA holds promise as an effective tool to predict the course metastatic breast cancer (MBC). In present study we used targeted next generation sequencing ctDNA evaluate impact driven mutations on prognosis MBC. The included 59 oestrogen receptor-positive (ER+), HER2-negative MBC patients. Sequencing was performed in ESR1, PIK3CA, ERBB2, PTEN, TP53, KRAS, HRAS, NRAS, and AR. At baseline, patients started receiving either chemotherapy...
The acquired JAK2 V617F mutation is common in patients with myeloproliferative neoplasms. We previously showed that also found coronary patients, most of them affected by atherosclerosis. Peripheral arterial disease (PAD) another important manifestation However, prevalence the and its effect on clinical or hematologic characteristics unknown PAD patients. In present study we determined a cohort 287 sonographically proven compared frequency mutational status 997 healthy people from KORA F4...