A5050511107- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- BRCA gene mutations in cancer
- Ovarian cancer diagnosis and treatment
- Asthma and respiratory diseases
- Cancer, Lipids, and Metabolism
- Gynecological conditions and treatments
- Patient-Provider Communication in Healthcare
- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Uterine Myomas and Treatments
- Acute Myocardial Infarction Research
- HER2/EGFR in Cancer Research
- Mechanical Circulatory Support Devices
- Renal cell carcinoma treatment
- Endometrial and Cervical Cancer Treatments
- Cancer therapeutics and mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Reproductive System and Pregnancy
- Cardiovascular Function and Risk Factors
- Ethics in Clinical Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
Peter MacCallum Cancer Centre
2019-2025
Emory University
2016-2024
University of Newcastle Australia
2017-2023
Hunter Medical Research Institute
2022
University of Pennsylvania
2016-2017
Emory Clinic
2017
MedStar Washington Hospital Center
2016
MedStar Heart & Vascular Institute
2016
Northwestern University
2016
Stony Brook University
2016
Rationale: Potential benefits of mesenchymal stem cell (MSC) therapy in heart failure may be related to paracrine properties and systemic effects, including anti-inflammatory activities. If this hypothesis is valid, intravenous administration MSCs should improve outcomes failure, an entity which excessive chronic inflammation play a pivotal role. Objective: To assess the safety preliminary efficacy intravenously administered ischemia-tolerant (itMSCs) patients with nonischemic...
Abstract There is limited knowledge on the benefit of α-subunit–specific PI3K inhibitor alpelisib in later lines therapy for advanced estrogen receptor–positive (ER+) HER2− and triple-negative breast cancer (TNBC). We conducted a phase II multicohort study monotherapy patients with pathway mutant ER+HER2− TNBC. In intention-to-treat ER+ cohort, overall response rate was 30% clinical 36%. A decline circulating tumor DNA (ctDNA) levels from baseline to week 8 while significantly associated...
Abstract Background Metastatic breast cancer remains incurable. Next-generation sequencing (NGS) offers the ability to identify actionable genomic alterations in tumours which may then be matched with targeted therapies, but implementation and utility of this approach is not well defined for patients metastatic cancer. Methods We recruited advanced any subtype prospective NGS their most recent tumour samples, using a panel 108 cancer-specific genes. Genes were classified as or non-actionable...
Endometrial cancer is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over last two decades. Despite understanding major signaling pathways driving growth metastasis endometrial cancer, clinical trials targeting these signals have reported poor outcomes. The heterogeneous nature suspected to be key reasons for failure targeted therapies. In this study, we perform a sequential window acquisition all theoretical fragment...
Abstract Background Although use of the mechanical ventilator is a life-saving intervention, excessive tidal volumes will activate NF-κB in lung with subsequent induction edema formation, neutrophil infiltration and proinflammatory cytokine/chemokine release. The roles IL-6 ventilator-induced injury (VILI) remain widely debated. Methods To study molecular mechanisms pathogenesis VILI, mice deletion IкB kinase myeloid cells (IKKβ △mye ), -/- to WT chimeric mice, C57BL/6 (WT) were placed on...
Recent studies showed that genetic aberrations in the MED12 gene, probably through canonical WNT/β-catenin pathway, lead to pathogenesis of uterine fibroids. However, a comprehensive analysis WNT pathway MED12-mutated and MED12-wild-type fibroids has not been performed. The objective this study was determine status human We performed Sanger sequencing define mutational normal myometrium samples. qPCR arrays were carried out signaling Liquid chromatography-mass spectrometry (LC-MS), Western...
Background Metastatic breast cancer (mBC) is a heterogenous disease with increasing availability of targeted therapies as well emerging genomic markers therapeutic resistance, necessitating timely and accurate molecular characterization disease. As minimally invasive test, analysis circulating tumour DNA (ctDNA) positioned for real-time profiling to guide treatment decisions. Here, we report the results prospective testing program established assess feasibility ctDNA clinical management mBC...
4577 Background: We hypothesised pembro could be added without undue toxicity to CRT and would improve efficacy in patients (pts) with MIBC. Methods: This multicentre phase 2 trial included people non-metastatic cT2-T4aN0M0 MIBC (>50% urothelial histology) who declined cystectomy or for whom was unsuitable, no contraindications pembro, ECOG performance status 0 1, eGFR ≥40 mL/min. Neoadjuvant chemotherapy not permitted. Pts had maximal TURBT, then whole bladder radiation therapy (RT)...
The central characteristic of uterine fibroids is excessive deposition extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little known about patterns ECM protein expression in whether these are influenced by the most common genetic anomalies, relate MED12. We performed extensive proteomic analyses clinically annotated adjacent normal myometrium identify composition proteins MED12 mutation-positive mutation-negative fibroids. Genetic...
Unopposed oestrogen is responsible for approximately 80% of all the endometrial cancers. The relationship between unopposed and cancer was indicated by increase in number cases due to widespread use replacement therapy. Approximately 30% patients have mutations Wnt signalling pathway. How unbalanced ratios ovarian hormones pathway interact cause currently unclear. To study this, we developed a uterine epithelial cell-specific inducible cre mouse model used 3D vitro culture human cell lines....
Background: Black patients have higher rates of hospitalization for acute heart failure than other race/ethnic groups. We sought to determine whether diuretic efficiency is associated with racial differences in risk rehospitalization after failure. Methods: A post hoc analysis was performed on 721 subjects (age, 68±13 years; 22% black) enrolled 3 clinical trials: ROSE-AHF (Renal Optimization Strategies Evaluation Acute Heart Failure), DOSE-AHF (Diuretic Strategy Decompensated and CARRESS-HF...
Asthma is a variable condition with an apparent tendency for natural decline in asthma symptoms and health care use occurring as children age. As result, interventions using pre-post design may overestimate the intervention effect when no proper control group available.Investigate patterns of over time increasing age children. Develop statistical procedure that enables adjustment accounts expected declines these outcomes useable evaluations must rely solely on data.Mixed-effects models...
Negotiated treatment plans are increasingly recommended in asthma clinical care. However, limited data available to indicate whether this more patient-engaged process results improved health outcomes. The aim of study was determine the associations between presence a negotiated plan and outcomes related adherence medical regimen, symptom control, care use. focus on women, subgroup adult patients, who most vulnerable for negative Data were collected by telephone interview record review from...
Background Ashkenazi Jewish (AJ) people have a higher incidence of BRCA1/2 pathogenic variants (PVs) than unselected populations. Three BRCA -Jewish founder mutations (B-JFMs) comprise >90% PVs in AJ people. Personal/family cancer history-based testing misses ≥50% with B-JFM. Methods We compared two population-based B-JFM screening programmes Australia—using (1) an online tool (Sydney) and (2) in-person group sessions (Melbourne). Results Of 2167 tested (Sydney n=594; Melbourne n=1573),...
5565 Background: Platinum resistant high grade serous ovarian cancer (HGSC) is associated with a poor prognosis and limited treatment options. Immune checkpoint inhibitors have failed to show significant impact in of HGSC date. Bevacizumab (anti-VEGF) atezolizumab (anti-PDL1) shown synergy multiple types. Cobimetinib (MEK inhibitor) may also potentiate immune responses, particularly by altering the tumour microenvironment. We sought evaluate efficacy cobimetinib, bevacizumab women platinum...
Objectives. To assess the relationship between season of birth and presence asthma allergy in preteen, low-income, African American children. Methods. The study consisted a self-administered survey followed by telephone interviews parents children attending 19 middle schools Detroit, Michigan. Out 4194 children, 1292 were identified with 962 these provided informed consent took part interviews. Results. No statistically significant relationships observed diagnosis (p > .05) or adjusting for...
Background The changing clinical research recruitment landscape involves practical challenges but introduces opportunities. Researchers can now identify large numbers of eligible patients through electronic health record review and directly contact those who have authorized contact. Applying behavioral science-driven strategies to design frame communication could affect patients' willingness authorize their understanding these programs. ethical implications various warrant empirical...
The direct ex vivo expansion of hematopoietic stem cells (HSCs) extracted from umbilical cord blood (UCB) was investigated by a membrane filtration method using polyurethane foaming (PU) membranes with various nano-segments and pore sizes. After filtering UCB through the washing membranes, were placed into culture medium, where HSCs expanded in three-dimensional environment. greatest obtained PU containing carboxylic acid. larger pores (11 μm) exhibited greater than smaller (6 μm), or...
People of Ashkenazi Jewish (AJ) ancestry are more likely than unselected populations to have a BRCA1/2 pathogenic variant, which cause significantly increased risk breast, ovarian and prostate cancer. Three specific variants, referred as BRCA-Jewish founder mutations (B-JFM), account for >90% variants in people AJ ancestry. Current practice identifying eligible individuals BRCA testing based on personal and/or family history has been shown miss at least 50% who one these variants. Here we...