A5020204643- Cardiac Health and Mental Health
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
- Cardiac and Coronary Surgery Techniques
- Lipoproteins and Cardiovascular Health
- Cardiovascular Effects of Exercise
- Cardiovascular Health and Disease Prevention
- Stress Responses and Cortisol
- Protease and Inhibitor Mechanisms
- Mesenchymal stem cell research
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- Cardiovascular Function and Risk Factors
- Telomeres, Telomerase, and Senescence
- Health Systems, Economic Evaluations, Quality of Life
- Atherosclerosis and Cardiovascular Diseases
- Restless Legs Syndrome Research
- Health disparities and outcomes
Emory University
2016-2025
Emory Healthcare
2018-2024
Emory Clinic
2016-2024
SomaLogic (United States)
2024
Emory and Henry College
2016-2023
Cardiovascular Institute Hospital
2021
University of Michigan
2020
Clinical Research Institute
2019
Emory University Hospital
2019
B. Braun (Netherlands)
2018
Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and associated worse prognosis. Young women a previous infarction (MI), group unexplained higher mortality than men of comparable age, have shown elevated rates MSIMI, but the mechanisms are unknown.
Previous studies have shown lower cardiovascular risk with higher high-density lipoprotein cholesterol (HDL-C) levels. However, recent data in the general population increased of adverse outcomes at very high HDL-C concentrations.To study association between levels (>80 mg/dL) and mortality patients coronary artery disease (CAD) to investigate known genotypes level outcomes.This prospective, multicenter, cohort study, conducted from 2006 present UK 2003 Atlanta, Georgia, recruited CAD...
<h3>Importance</h3> Mental stress–induced myocardial ischemia is a recognized phenomenon in patients with coronary heart disease (CHD), but its clinical significance the contemporary era has not been investigated. <h3>Objective</h3> To compare association of mental or conventional adverse cardiovascular events CHD. <h3>Design, Setting, and Participants</h3> Pooled analysis 2 prospective cohort studies stable CHD from university-based hospital network Atlanta, Georgia: Stress Ischemia...
Background The associations between high‐sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity progression remain unclear. We investigated whether there is an association hsTnI angiographic of CAD the predictive value level for incident cardiovascular outcomes independent severity. Methods Results In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence acute myocardial infarction, was calculated by number major arteries with...
Background Food deserts ( FDs ), defined as low-income communities with limited access to healthy food, are a growing public health concern. We evaluated the impact of living in on incident cardiovascular events. Methods and Results recruited 4944 subjects (age 64±12, 64% male) undergoing cardiac catheterization into Emory Cardiovascular Biobank. Using US Department Agriculture definition FD , we determined whether their residential addresses had (1) poor (2) low income, or (3) both (= )....
Leukocyte telomere length (LTL) is a biological marker of aging, and shorter LTL associated with adverse cardiovascular outcomes. Reduced regenerative capacity has been proposed as mechanism. Bone marrow-derived circulating progenitor cells are involved in tissue repair regeneration.Main objective this study was to examine the relationship between their impact on outcomes.We measured by quantitative polymerase chain reaction 566 outpatients (age: 63±9 years; 76% men) coronary artery disease....
Objective— To investigate sex-specific vascular mechanisms for mental stress-induced myocardial ischemia (MSIMI). Approach and Results— Baseline data from a prospective cohort study of 678 patients with coronary artery disease underwent perfusion imaging before during public speaking stressor. The rate-pressure product response was calculated as the difference between maximum value speech minus minimum rest. Peripheral vasoconstriction by peripheral arterial tonometry ratio pulse wave...
Coronary microvascular dysfunction may contribute to myocardial ischemia during mental stress (MS). However, the role of coronary epicardial and function in regulating blood flow (CBF) responses MS remains understudied. We hypothesized that vasomotion is dependent on endothelial will be reflected peripheral circulation.In 38 patients aged 59±8 years undergoing angiography, endothelium-dependent endothelium-independent were measured using intracoronary acetylcholine nitroprusside,...
Background Educational attainment is an indicator of socioeconomic status and inversely associated with coronary artery disease risk. Whether educational level ( EAL ) among patients influences outcomes remains understudied. Methods Results Patients undergoing cardiac catheterization had their highest assessed using options elementary/middle school, high college, or graduate education. Primary outcome was all‐cause mortality secondary were a composite cardiovascular death/non‐fatal...
Microvascular measures of vascular dysfunction during acute mental stress may be important determinants major adverse cardiovascular events (MACE), especially among younger and middle-aged women survivors an myocardial infarction.
Vitamin D deficiency (VDD) is associated with coronary heart disease (CHD) and poor outcomes, but supplementation does not improve prognosis. VDD has been implicated in may promote greater risk through inflammation impaired progenitor cell function.
Endogenous regenerative capacity, assessed as circulating progenitor cell (PC) numbers, is an independent predictor of adverse outcomes in patients with cardiovascular disease. However, their predictive role heart failure (HF) remains controversial. We the relationship between number PCs and pathogenesis severity HF impact on incident events.We recruited 2049 adults which 651 had diagnosis. were enumerated by flow cytometry CD45med+ blood mononuclear cells expressing CD34, CD133, vascular...
<h3>Importance</h3> Former US football athletes are at increased risk of cardiovascular (CV) morbidity and mortality compared with the general population other professional athletes. However, responsible maladaptive CV phenotypes have not been fully characterized. <h3>Objective</h3> To address emergence progression multiple independent factors associated across serial years collegiate participation. <h3>Design, Setting, Participants</h3> Collegiate from 2 National Athletic Association...
Rationale: Circulating progenitor cells (CPCs) mobilize in response to ischemic injury, but their predictive value remains unknown acute coronary syndrome (ACS). Objective: We aimed investigate the number of CPCs ACS compared with those stable artery disease (CAD), relationship between bone marrow PCs and CPCs, whether CPC counts predict mortality patients ACS. Methods Results: In 2028 patients, 346 had unstable angina, 183 an myocardial infarction (AMI), remaining 1499 CAD. Patients were...
Rationale: Excessive vasoconstriction in response to mental stress may be a potential mechanism by which acute psychological leads adverse cardiac events. Objectives: We investigated whether excessive digital during predicts cardiovascular outcomes among patients with coronary artery disease. Methods and Results: Five hundred forty-nine stable disease (age 63±9, 76% male, 29% black) underwent testing standardized public speaking stressor followed prospectively for end points. Digital pulse...
Abstract The influence of acute psychological stress on cardiovascular disease is an emerging public health concern. Identification brain mechanisms underlying this may aid in the discovery possible treatments. Acute induce arteriolar vasoconstriction and reduce blood flow to vital organs. We hypothesized that functional changes regions involved with memory autonomic/emotional regulation are implicated vasoconstrictive response, including medial prefrontal cortex (anterior cingulate),...