A5048520477- Cardiac Health and Mental Health
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Cardiac Structural Anomalies and Repair
- Metabolomics and Mass Spectrometry Studies
- Geochemistry and Geologic Mapping
- Gut microbiota and health
- Health disparities and outcomes
- Heart Failure Treatment and Management
- Cardiovascular Health and Disease Prevention
- Cardiac Arrest and Resuscitation
- Stress Responses and Cortisol
- Oral microbiology and periodontitis research
- Workplace Health and Well-being
- Colorectal Cancer Screening and Detection
- Cardiac pacing and defibrillation studies
- COVID-19 and Mental Health
- Mindfulness and Compassion Interventions
- Statistical Methods and Bayesian Inference
- COVID-19 epidemiological studies
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Underwater Vehicles and Communication Systems
- Meta-analysis and systematic reviews
- Face recognition and analysis
Emory University
2018-2024
Zhejiang University of Technology
2022
Robert Wood Johnson Foundation
2021
Emory Healthcare
2021
Saint Barnabas Medical Center
2021
Emory and Henry College
2020
State Key Laboratory of Modern Optical Instruments
2019
Zhejiang University
2019
<h3>Importance</h3> Mental stress–induced myocardial ischemia is a recognized phenomenon in patients with coronary heart disease (CHD), but its clinical significance the contemporary era has not been investigated. <h3>Objective</h3> To compare association of mental or conventional adverse cardiovascular events CHD. <h3>Design, Setting, and Participants</h3> Pooled analysis 2 prospective cohort studies stable CHD from university-based hospital network Atlanta, Georgia: Stress Ischemia...
The COVID-19 pandemic adversely affected the socially vulnerable and minority communities in USA initially, but temporal trends during year-long remain unknown.
Compositional analysis is based on the premise that a relatively small proportion of taxa are differentially abundant, while ratios relative abundances remaining remain unchanged. Most existing methods use log-transformed data, but log-transformation data with pervasive zero counts problematic, and these cannot always control false discovery rate (FDR). Further, high-throughput microbiome such as 16S amplicon or metagenomic sequencing subject to experimental biases introduced in every step...
Psychological distress is a recognized risk factor in patients with coronary heart disease (CHD), but its clinical significance unclear. The purpose of this study was to determine if an index psychological independently associated adverse outcomes and significantly contributes prediction. Pooled analysis 2 prospective cohort studies stable CHD (N = 891). A score constructed using measures depression, anxiety, anger, perceived stress, post-traumatic stress disorder, measured at baseline....
Microvascular measures of vascular dysfunction during acute mental stress may be important determinants major adverse cardiovascular events (MACE), especially among younger and middle-aged women survivors an myocardial infarction.
Patients with chronic kidney disease (CKD) exhibit increased blood pressure reactivity during exercise that is associated endothelial dysfunction. Twelve weeks of structured, aerobic, training improves function and attenuates peak responses in CKD stages III–IV.
We used the International Society for Heart and Lung Transplantation (ISHLT) Registry Mechanically Assisted Circulatory Support (IMACS) database to examine 1) gender differences in post-left ventricular assist device (LVAD) mortality contemporary era 2) preimplant clinical factors that might mediate any observed differences. Adults who received continuous-flow (CF)-LVAD from January 2013 September 2017 (n = 9,565, age: 56.2 ± 13.2 years, 21.6% female, 31.1% centrifugal pumps) were analyzed....
Posttraumatic stress disorder (PTSD) is characterized by increased risk for developing hypertension and cardiovascular disease. We recently showed that device-guided slow breathing (DGB) acutely lowers blood pressure (BP) muscle sympathetic activity (MSNA) improves baroreflex sensitivity (BRS) in PTSD. The aim of this study was to assess the long-term benefits DGB on autonomic function at rest during stress. hypothesized arterial BRS BP MSNA Twenty-five veterans with PTSD were studied...
<h3>Importance</h3> Compared with older patients, young adults a history of myocardial infarction (MI) tend to have higher burden psychosocial adversity. Exposure early-life stressors may contribute the risk adverse outcomes in this patient population, potentially through inflammatory pathways. <h3>Objective</h3> To investigate association trauma events and examine whether inflammation plays role. <h3>Design, Setting, Participants</h3> This cohort study included patients aged 18 60 years...
Abstract Chronic kidney disease (CKD) is characterized by overactivation of the sympathetic nervous system (SNS) that leads to increased risk cardiovascular disease. This study was conducted evaluate effects a Mindfulness‐Based Stress Reduction (MBSR) programme on SNS activity in CKD patients. Participants with stages III–IV were randomized 8 week MBSR or Health Enhancement Program (HEP; structurally parallel, active control group). Intraneural measures directed muscle [muscle nerve (MSNA)]...
Oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) is highly effective in preventing HIV infection among men who have sex (MSM). The effects of consistent personal lubricant use the rectum on tissue PrEP drug concentrations rectal microbiota are unknown. We investigated MSM before after repeated application a hyperosmolar lubricant.We randomized 60 HIV-negative to apply 4 mL daily (n = 20), take oral TDF/FTC 19), or both 21) for seven days....
Females have increased risk of right-ventricular failure (RVF) and 3 month mortality after left-ventricular assist device (LVAD) implantation. In this translational study, we tested the hypothesis that sex differences in outcomes are driven by pump-induced LV size-volume mismatch, due to a negative impact on interventricular septal (IVS) interdependence. Adult continuous-flow LVAD recipients from International Society For Heart And Lung Transplantation Mechanically Assisted Circulatory...
Posttraumatic stress disorder (PTSD) is an independent risk factor for the development of hypertension and cardiovascular disease. Patients with PTSD have heightened blood pressure sympathetic nervous system reactivity; however, it unclear if patients exaggerated vasoconstriction in response to nerve activation that could also contribute increased reactivity. Therefore, we hypothesized sensitivity vascular α1-adrenergic receptors (α1ARs), major mediators release norepinephrine at terminals....
Background Prior studies have shown that women worse 3-month survival after receiving a left ventricular assist device compared with men. Currently used prognostic scores, including the Heartmate II Risk Score, do not account for increased residual risk in women. We IMACS (International Society Heart and Lung Transplantation Mechanically Assisted Circulatory Support) registry to create validate sex-specific score early mortality recipients. Methods Results Adult patients continuous-flow LVAD...
Background Finding microbiome associations with possibly censored survival times is an important problem, especially as specific taxa could serve biomarkers for disease prognosis or targets therapeutic interventions. The two existing methods outcomes, MiRKAT-S and OMiSA, are restricted to testing at the community level do not provide results individual taxon level. An ad hoc approach each a outcome using Cox proportional hazard model may perform well in setting sparse count data small sample...
Forward-looking sonar is a technique widely used for underwater detection. However, most images have noise and low resolution due to their acoustic properties. In recent years, the semantic segmentation model U-Net has shown excellent performance, it great potential in forward-looking image segmentation. are affected by noise, which prevents existing from segmenting small objects effectively. Therefore, this study presents called Feature Pyramid with Attention (FPUA). This uses residual...
ABSTRACT OBJECTIVES To investigate differences in transient endothelial dysfunction (TED) with mental stress Black and non-Black individuals coronary heart disease (CHD), their potential impact on cardiovascular outcomes. METHODS We examined 812 patients stable CHD between June 2011 March 2016 followed through February 2020 at a University-affiliated hospital network. Flow mediated vasodilation (FMD) was assessed before 30 minutes after stress. TED defined as lower post-stress FMD than...
Evidence suggests that intravaginal practices (IVPs) women use to cleanse their vagina or enhance sexual pleasure may be associated with unhealthy changes in the vaginal microbiome (VM). However, effects of these postmenopausal are unknown.The objective this pilot study was characterize VM communities women, identify types and frequency IVPs, explore associations between IVPs women.We analyzed data 21 Atlanta, Georgia, from swabs collected at a routine gynecological visit. 16S rRNA gene...
Recent advancements of multimodal neuroimaging such as functional MRI (fMRI) and diffusion (dMRI) offers unprecedented opportunities to understand brain development. Most existing neurodevelopmental studies focus on using a single imaging modality study microstructure or neural activations in localized regions. The developmental changes network architecture childhood adolescence are not well understood. Our made use dMRI resting-state fMRI data sets from Philadelphia Neurodevelopmental...
Abstract Background Finding microbiome associations with possibly censored survival times is an important problem, especially as specific taxa could serve biomarkers for disease prognosis or targets therapeutic interventions. The two existing methods outcomes, MiRKAT-S and OMiSA, are restricted to testing at the community level do not provide results individual taxon level. An ad hoc approach each a outcome using Cox proportional hazard model may perform well in setting sparse count data...
Chronic kidney disease (CKD) is characterized by overactivation of the sympathetic nervous system (SNS) that leads to increased cardiovascular risk. Despite deleterious consequences SNS overactivity, there are very few therapeutic options available combat overactivity.
The electronic health records (EHR) infrastructure offers a tremendous resource for identifying controls who match the characteristics of study participants in single-arm trial. objectives are to (1) demonstrate feasibility curating synthetic control group an existing cohort through EHR data extraction and (2) evaluate effect lifestyle intervention on selected cardiovascular metrics. A total 711 university employees were recruited between 2008 2012 participate partner improve followed five...
Microbiome data are subject to experimental bias that is caused by DNA extraction, PCR amplification among other sources, but this important feature often ignored when developing statistical methods for analyzing microbiome data. McLaren, Willis and Callahan (2019) proposed a model how such affects the observed taxonomic profiles, which assumes main effects of without taxon-taxon interactions. Our newly developed method, LOCOM (logistic regression compositional analysis) testing differential...